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冠状病毒抑制剂|New coronavirus inhibitor

SARS-CoV(SARS冠状病毒)是引起严重急性呼吸道综合症(SARS)的病毒。 冠状病毒编码的木瓜蛋白酶样蛋白酶(PLpro)通常是具有蛋白酶活性的多功能酶,具有加工病毒复制酶多蛋白和去泛素化(DUB)/ deISGylating活性的作用,假定该酶可以修饰对感染的先天免疫应答。冠状病毒抑制剂主要用于新型新型冠状病毒的先导化合物,进行抗新型冠状病毒(2019-nCoV)潜在药物的筛选研究和新药研发使用,不可直接应用于人体使用。The study of the structure of virus is an important implication for the exploring and development of effective antivirals. At present, S protein, TMPRSS2, ACE2, RdRp, and Mpro are primary targets. For example, Lopinavir as a protease inhibitor combined with Ritonavir performs against antiretroviral activity. Remdesivir, as a nucleotide analogue, shows an effective activity against SARS-CoV-2 through inhibiting RdRp.

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