30413-87-7|Umbelliprenin|7-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)-2H-chromen-2-one|-范德生物科技公司

Umbelliprenin

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names：
7-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)-2H-chromen-2-one
CAS号：
30413-87-7
MDL Number：
MF(分子式)： C24H30O3 MW(分子量)： 366.5
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	7-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)-2H-chromen-2-one
英文别名	Angelin, Umbelliprenin
CAS号	30413-87-7
Inchi	1S/C24H30O3/c1-18(2)7-5-8-19(3)9-6-10-20(4)15-16-26-22-13-11-21-12-14-24(25)27-23(21)17-22/h7,9,11-15,17H,5-6,8,10,16H2,1-4H3/b19-9+,20-15+
InchiKey	GNMUGVNEWCZUAA-WOWYBKFKSA-N
分子式 Formula	C24H30O3
分子量 Molecular Weight	366.5
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Umbelliprenin(CAS:30413-87-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Umbelliprenin, also known as Angelin, is a prenyloxy-coumarin which may have anti-inflammatory, anti-tumor, antioxidant, and antigenotoxic activities.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
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备注

[1]Naderi Alizadeh M, Rashidi M, Muhammadnejad A, Moeini Zanjani T, Ziai SA. Antitumor Effects of Umbelliprenin in a Mouse Model of Colorectal Cancer. Iran J Pharm Res. 2018 Summer;17(3):976-985. PubMed PMID: 30127820; PubMed Central PMCID: PMC6094438.

[2]Rashidi M, Khalilnezhad A, Amani D, Jamshidi H, Muhammadnejad A, Bazi A, Ziai SA. Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice. J Cell Physiol. 2018 Nov;233(11):8908-8918. doi: 10.1002/jcp.26814. Epub 2018 May 24. PubMed PMID: 29797576.

[3] Khaghanzadeh N, Samiei A, Mojtahedi Z, Ramezani M, Hosseinzadeh M, Ghaderi A. Umbelliprenin induced both anti-inflammatory and regulatory cytokines in C57/BL6 mice. Iran J Basic Med Sci. 2017 Jul;20(7):829-834. doi: 10.22038/IJBMS.2017.9021. PubMed PMID: 28852449; PubMed Central PMCID: PMC5569593.

[4] Khaghanzadeh N, Nakamura K, Kuramitsu Y, Ghaderi A, Mojtahedi Z. Immune-associated proteins with potential in vivo anti-tumor activities are upregulated in lung cancer cells treated with umbelliprenin: A proteomic approach. Oncol Lett. 2016 Dec;12(6):5295-5302. doi: 10.3892/ol.2016.5352. Epub 2016 Nov 4. PubMed PMID: 28105238; PubMed Central PMCID: PMC5228441.

[5] Rashidi M, Ziai SA, Moini Zanjani T, Khalilnezhad A, Jamshidi H, Amani D. Umbelliprenin is Potentially Toxic Against the HT29, CT26, MCF-7, 4T1, A172, and GL26 Cell Lines, Potentially Harmful Against Bone Marrow-Derived Stem Cells, and Non-Toxic Against Peripheral Blood Mononuclear Cells. Iran Red Crescent Med J. 2016 May 14;18(7):e35167. eCollection 2016 Jul. PubMed PMID: 27703798; PubMed Central PMCID: PMC5027671.

6: Khaghanzadeh N, Samiei A, Ramezani M, Mojtahedi Z, Hosseinzadeh M, Ghaderi A. Umbelliprenin induced production of IFN-γ and TNF-α, and reduced IL-10, IL-4, Foxp3 and TGF-β in a mouse model of lung cancer. Immunopharmacol Immunotoxicol. 2014 Feb;36(1):25-32. doi: 10.3109/08923973.2013.863912. Epub 2013 Dec 11. PubMed PMID: 24325354.7: Khaghanzadeh N, Mojtahedi Z, Ramezani M, Erfani N, Ghaderi A. Umbelliprenin is cytotoxic against QU-DB large cell lung cancer cell line but anti-proliferative against A549 adenocarcinoma cells. Daru. 2012 Oct 30;20(1):69. doi: 10.1186/2008-2231-20-69. PubMed PMID: 23351548; PubMed Central PMCID: PMC3556042.8: Ziai SA, Gholami O, Iranshahi M, Zamani AH, Jeddi-Tehrani M. Umbelliprenin Induces Apoptosis in CLL Cell Lines. Iran J Pharm Res. 2012 Spring;11(2):653-9. PubMed PMID: 24250490; PubMed Central PMCID: PMC3832171.9: Iranshahi M, Sahebkar A, Takasaki M, Konoshima T, Tokuda H. Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. Eur J Cancer Prev. 2009 Sep;18(5):412-5. doi: 10.1097/CEJ.0b013e32832c389e. PubMed PMID: 19531956.10: Barthomeuf C, Lim S, Iranshahi M, Chollet P. Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. Phytomedicine. 2008 Jan;15(1-2):103-11. Epub 2007 Aug 8. PubMed PMID: 17689942.

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