76554-66-0|Ro 09-0410|4'-Ethoxy-2'-hydroxy-4,6'-dimethoxychalcone|-范德生物科技公司

Ro 09-0410

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names：
4'-Ethoxy-2'-hydroxy-4,6'-dimethoxychalcone
CAS号：
76554-66-0
MDL Number：
MF(分子式)： C19H20O5 MW(分子量)： 328.36
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	4'-Ethoxy-2'-hydroxy-4,6'-dimethoxychalcone
英文别名	Ro 09-0410; Ro 09 0410; Ro-09-0410.
CAS号	76554-66-0
Inchi	InChI=1S/C19H20O5/c1-4-24-15-11-17(21)19(18(12-15)23-3)16(20)10-7-13-5-8-14(22-2)9-6-13/h5-12,21H,4H2,1-3H3/b10-7+
InchiKey	IZRDKZYYVCGVRH-JXMROGBWSA-N
分子式 Formula	C19H20O5
分子量 Molecular Weight	328.36
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ro 09-0410(CAS:76554-66-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ro 09-0410 is antivirus agent. It is suggested it binds to human rhinovirus type 2 (HRV-2) and made it inactive.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Dewindt B, van Eemeren K, Andries K. Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral Res. 1994 Sep;25(1):67-72. PubMed PMID: 7811059.

[2]Almela MJ, González ME, Carrasco L. Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles. J Virol. 1991 May;65(5):2572-7. PubMed PMID: 1850030; PubMed Central PMCID: PMC240614.

[3] Yasin SR, al-Nakib W, Tyrrell DA. Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410. Antimicrob Agents Chemother. 1990 Jun;34(6):963-6. PubMed PMID: 2168152; PubMed Central PMCID: PMC171738.

[4] Ninomiya Y, Shimma N, Ishitsuka H. Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides. Antiviral Res. 1990 Feb;13(2):61-74. PubMed PMID: 2160796.

[5] Al-Nakib W, Higgins PG, Barrow I, Tyrrell DA, Lenox-Smith I, Ishitsuka H. Intranasal chalcone, Ro 09-0410, as prophylaxis against rhinovirus infection in human volunteers. J Antimicrob Chemother. 1987 Dec;20(6):887-92. PubMed PMID: 3326874.

6: Ahmad AL, Dowsett AB, Tyrrell DA. Studies of rhinovirus resistant to an antiviral chalcone. Antiviral Res. 1987 Aug;8(1):27-39. PubMed PMID: 2825590.7: Ishitsuka H, Ninomiya Y, Suhara Y. Molecular basis of drug resistance to new antirhinovirus agents. J Antimicrob Chemother. 1986 Oct;18 Suppl B:11-8. PubMed PMID: 3025150.8: Ahmad AL, Tyrrell DA. Synergism between anti-rhinovirus antivirals: various human interferons and a number of synthetic compounds. Antiviral Res. 1986 Jul;6(4):241-52. PubMed PMID: 3017203.9: Selway JW. Antiviral activity of flavones and flavans. Prog Clin Biol Res. 1986;21

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