76554-66-0|Ro 09-0410|4'-Ethoxy-2'-hydroxy-4,6'-dimethoxychalcone|-范德生物科技公司

Ro 09-0410

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names：
4'-Ethoxy-2'-hydroxy-4,6'-dimethoxychalcone
CAS号：
76554-66-0
MDL Number：
MF(分子式)： C19H20O5 MW(分子量)： 328.36
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	4'-Ethoxy-2'-hydroxy-4,6'-dimethoxychalcone
英文别名	Ro 09-0410; Ro 09 0410; Ro-09-0410.
CAS号	76554-66-0
SMILES	O=C(C1=C(OC)C=C(OCC)C=C1O)/C=C/C2=CC=C(OC)C=C2
Inchi	InChI=1S/C19H20O5/c1-4-24-15-11-17(21)19(18(12-15)23-3)16(20)10-7-13-5-8-14(22-2)9-6-13/h5-12,21H,4H2,1-3H3/b10-7+
InchiKey	IZRDKZYYVCGVRH-JXMROGBWSA-N
分子式 Formula	C19H20O5
分子量 Molecular Weight	328.36
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ro 09-0410(CAS:76554-66-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ro 09-0410 is antivirus agent. It is suggested it binds to human rhinovirus type 2 (HRV-2) and made it inactive.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Dewindt B, van Eemeren K, Andries K. Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral Res. 1994 Sep;25(1):67-72. PubMed PMID: 7811059.

[2]Almela MJ, González ME, Carrasco L. Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles. J Virol. 1991 May;65(5):2572-7. PubMed PMID: 1850030; PubMed Central PMCID: PMC240614.

[3] Yasin SR, al-Nakib W, Tyrrell DA. Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410. Antimicrob Agents Chemother. 1990 Jun;34(6):963-6. PubMed PMID: 2168152; PubMed Central PMCID: PMC171738.

[4] Ninomiya Y, Shimma N, Ishitsuka H. Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides. Antiviral Res. 1990 Feb;13(2):61-74. PubMed PMID: 2160796.

[5] Al-Nakib W, Higgins PG, Barrow I, Tyrrell DA, Lenox-Smith I, Ishitsuka H. Intranasal chalcone, Ro 09-0410, as prophylaxis against rhinovirus infection in human volunteers. J Antimicrob Chemother. 1987 Dec;20(6):887-92. PubMed PMID: 3326874.

6: Ahmad AL, Dowsett AB, Tyrrell DA. Studies of rhinovirus resistant to an antiviral chalcone. Antiviral Res. 1987 Aug;8(1):27-39. PubMed PMID: 2825590.7: Ishitsuka H, Ninomiya Y, Suhara Y. Molecular basis of drug resistance to new antirhinovirus agents. J Antimicrob Chemother. 1986 Oct;18 Suppl B:11-8. PubMed PMID: 3025150.8: Ahmad AL, Tyrrell DA. Synergism between anti-rhinovirus antivirals: various human interferons and a number of synthetic compounds. Antiviral Res. 1986 Jul;6(4):241-52. PubMed PMID: 3017203.9: Selway JW. Antiviral activity of flavones and flavans. Prog Clin Biol Res. 1986;21

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