Lateritin|3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione|65454-13-9|-范德生物科技公司

Lateritin

Lateritin
NMR and HPLC COA下载 MSDS下载
Names：
3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione
CAS号：
65454-13-9
MDL Number：
MF(分子式)： C15H19NO3 MW(分子量)： 261.31
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK17326-1mg	1mg	>98%	¥ 5460.00	¥ 5460.00		2 Weeks	- +	¥ 0.00

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询价

中文别名	Lateritin
英文别名	Lateritin; Bassiatin;
CAS号	65454-13-9
SMILES	O=C(OC1C(C)C)C(CC2=CC=CC=C2)N(C)C1=O
Inchi	InChI=1S/C15H19NO3/c1-10(2)13-14(17)16(3)12(15(18)19-13)9-11-7-5-4-6-8-11/h4-8,10,12-13H,9H2,1-3H3
InchiKey	YOKBTBNVNCFOBF-UHFFFAOYSA-N
分子式 Molecular Weight	C15H19NO3
分子量 Formula	261.31
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility	Soluble in DMSO
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lateritin(CAS:65454-13-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lateritin is An Acyl-CoAcholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor isolated from the mycelial cake of Gibberella lateritium; bassiatin is the (3S,6R) isomer.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Pettit RK, Pettit GR, Xu JP, Weber CA, Richert LA. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-[1]doi: 10.1055/s-0029-1240617. Epub 2009 Nov 25. PubMed PMID: 19941263.

[2]Hasumi K, Shinohara C, Iwanaga T, Endo A. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo). 1993 Dec;46(12):1782-7. PubMed PMID: 8294234.

[3] Meng L, Tao H, Dong G, Yang T, Zhang W, Zhu W, Huang C. ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell Biol Int. 2012 Apr 1;36(4):345-8. doi: 10.1042/CBI20110388. PubMed PMID: 22150072.

[4] Meng L, Feng B, Tao H, Yang T, Meng Y, Zhu W, Huang C. A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17β-oestradiol-treated MCF-7 cells. Cell Biol Int. 2011 Jun;35(6):599-605. doi: 10.1042/CBI20100765. PubMed PMID: 21241249.

[5] Kagamizono T, Nishino E, Matsumoto K, Kawashima A, Kishimoto M, Sakai N, He BM, Chen ZX, Adachi T, Morimoto S, et al. Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717. J Antibiot (Tokyo). 1995 Dec;48(12):1407-12. PubMed PMID: 8557595.

6: Tang CY, Chen YW, Jow GM, Chou CJ, Jeng CJ. Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol. 2005 May;18(5):825-33. PubMed PMID: 15892576.7: Oh H, Kim T, Oh GS, Pae HO, Hong KH, Chai KY, Kwon TO, Chung HT, Lee HS. (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-perhydro-1,4-oxazine-2,5-dione: an apoptosis-inducer from the fruiting bodies of Isaria japonica. Planta Med. 2002 Apr;68(4):345-8. PubMed PMID: 11988860.8: Hughes AB, Sleebs MM. Total synthesis of bassiatin and its stereoisomers: novel divergent behavior of substrates in Mitsunobu cyclizations. J Org Chem. 2005 Apr 15;70(8):3079-88. PubMed PMID: 15822967.9: Jow GM, Chou CJ, Chen BF, Tsai JH. Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: the causative role of calcium. Cancer Lett. 2004 Dec 28;216(2):165-73. PubMed PMID: 15533592.10: Huang LH, Chen YX, Yu JC, Yuan J, Li HJ, Ma WZ, Watanapokasin R, Hu KC, Niaz SI, Yang DP, Lan WJ. Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity. Molecules. 2017 Mar 11;22(3). pii: E444. doi: 10.3390/molecules22030444. PubMed PMID: 28287456.1

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