205304-86-5|N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸|Tubulysin A|Not available-范德生物科技公司

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸

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names：
Tubulysin A
CAS号：
205304-86-5
MDL Number： Not available
MF(分子式)： C43H65N5O10S MW(分子量)： 844.069
EINECS:Not available Reaxys Number:Not available
Pubchem ID:12134544 Brand:BIOFOUNT

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸(205304-86-5,Tubulysin A)是一种新型抗生素，具有抗微管，抗有丝分裂，凋亡诱导剂，抗癌，抗血管生成和抗增殖作用。 Tubulysins对体外和体内肿瘤模型，特别是对耐药肿瘤细胞系，显示出非常高的细胞毒活性。这些天然产物的许多代表比其他可用化学治疗剂的效力高几个数量级。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
HCC351356-0.25mg	0.25mg	97%	¥ 4655.00	¥ 4655.00		4-7周	- +	¥ 0.00

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中文别名	N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸(205304-86-5,Tubulysin A)
英文别名	205304-86-5;Tubulysin A;TubA
CAS号	205304-86-5
Inchi	InChI=1S/C43H65N5O10S/c1-10-27(6)38(46-40(53)34-13-11-12-18-47(34)9)42(54)48(24-57-37(51)19-25(2)3)35(26(4)5)22-36(58-29(8)49)41-45-33(23-59-41)39(52)44-31(20-28(7)43(55)56)21-30-14-16-32(50)17-15-30/h14-17,23,25-28,31,34-36,38,50H,10-13,18-22,24H2,1-9H3,(H,44,52)(H,46,53)(H,55,56)/t27-,28+,31-,34-,35-,36-,38+/m1/s1
InchiKey	IBEDDHUHZBDXGB-AHVLMTIQSA-N
分子式 Formula	C43H65N5O10S
分子量 Molecular Weight	844.069
溶解度Solubility
性状	白色固体粉末
储藏条件 Storage conditions	干燥，黑暗，短期（几天至几周）处于0-4°C，长期（几个月至几年）处于-20°C。

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸(205304-86-5,Tubulysin A)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Tubulysin A(205304-86-5) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸(205304-86-5,Tubulysin A),Tubulysin A试剂,Tubulysin A抑制剂,Tubulysin A的纯度,Tubulysin A的使用,Tubulysin A的效果,Tubulysin A的外观,Tubulysin A的合成,Tubulysin A的生产

产品说明	N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸(205304-86-5,Tubulysin A)可以作为药物杂质对照品以及生物医药类试剂。
Introduction	Tubulysin A[N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸,205304-86-5] can be used as a reference substance for drug impurities and reagents，only for research.
Application1	Tubulysin A具有潜在的抗癌作用,它使细胞停滞在G2 / M期。
Application2	Tubulysin A比长春碱更有效地抑制聚合，并诱导分离的微管解聚。
Application3	Tubulysin A对各种肿瘤细胞系具有有效的细胞抑制作用

Tubulysin A（TubA）是一种粘细菌产品，可以在许多体外测定中充当抗血管生成剂。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303+H313+H333
安全防护	P264+P280+P305+P351+P338+P337+P313
备注	实验过程中防止吸入、食入，做好安全防护

Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives PMID 22595030; British journal of pharmacology 2012 Nov; 167(5)

Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria PMID 16491500; Chembiochem : a European journal of chemical biology 2006 Apr;

Polymeric tubulysin-peptide nanoparticles with potent antitumor activity PMID 19118045; Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan

Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives PMID 22595030; British journal of pharmacology 2012 Nov;

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy PMID 22722320; Molecular bioSystems 2012 Aug;

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy.
Eirich J;Burkhart JL;Ullrich A;Rudolf GC;Vollmar A;Zahler S;Kazmaier U;Sieber SA Mol Biosyst. 2012 Aug;8(8):2067-75. doi: 10.1039/c2mb25144b. Epub 2012 Jun 21.
Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by either stabilizing or de-stabilizing these rope-like polymers. Among those tubulysins represent a new and potent class of cytostatic tetrapeptides originating from myxobacteria. Early studies suggested that tubulysins interact with the eukaryotic cytoskeleton by inhibition of tubulin polymerization with EC?? values in the picomolar range. Recently, pretubulysins have been described to retain the high tubulin-degradation activity of their more complex tubulysin relatives and represent an easier synthetic target with an efficient synthesis already in place. Although tubulin has been suggested as the dedicated target of tubulysin a comprehensive molecular target analysis of pretubulysin in the context of the whole proteome has not been carried out so far. Here we utilize synthetic chemistry to develop two pretubulysin photoaffinity probes which were applied in cellular activity-based protein profiling and imaging studies in order to unravel and visualize dedicated targets.

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