58306-30-2|非班太尔|Febantel|MFCD00864513-范德生物科技公司

非班太尔

NMR下载 COA and HPLC MSDS下载
names：
Febantel
CAS号：
58306-30-2
MDL Number： MFCD00864513
MF(分子式)： C20H22N4O6S MW(分子量)： 446.48
EINECS:261-205-0 Reaxys Number:
Pubchem ID:135449328 Brand:BIOFOUNT

非班太尔(58306-30-2,Febantel)是一种广谱驱虫药，又名苯硫胍，非班太尔主要用于治疗和控制牛、羊、猪、马等动物的胃肠蛔虫、肺蠕虫、绦虫等，非班太尔具有高效、低毒、体内停留时间短、安全范围大等特点。非班太尔是一种属于苯并咪唑类化学物质的资深驱虫药。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
HCR200824-50mg	50mg	97%	¥ 665.00	¥ 665.00		4-7周	- +	¥ 0.00

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中文别名	非班太尔(58306-30-2,Febantel);非班太尔/苯硫胍;苯硫胍(非班太尔);N-{2-[2,3-双(甲氧基甲酰)-胍基]-5-(苯硫基)-苯基}-2-甲氧基乙酰胺;苯硫胍
英文别名	Febantel(58306-30-2);Rintal;Combotel;Oratel;Negabot Plus Paste;Bay Vh 5757
CAS号	58306-30-2
Inchi	InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27)
InchiKey	HMCCXLBXIJMERM-UHFFFAOYSA-N
分子式 Formula	C20H22N4O6S
分子量 Molecular Weight	446.48
溶解度Solubility	Chloroform (Sparingly)
性状	白色或类白色固体粉末
储藏条件 Storage conditions	2-8°C,密闭,在干燥处保存。

非班太尔(58306-30-2,Febantel)毒性测试：

生物	测试类型	路线	报告剂量（标准化剂量）	参考
rat	LD50	oral	10605 mg/kg (10605 mg/kg)	Arzneimittel-Forschung. Drug Research., 28(2193), 1978 [PMID:582930]
rat	LD50	subcutaneous	>10 gm/kg (10000 mg/kg)	Arzneimittel-Forschung. Drug Research., 28(2193), 1978 [PMID:582930]
mouse	LD50	oral	>10 gm/kg (10000 mg/kg)	Arzneimittel-Forschung. Drug Research., 28(2193), 1978 [PMID:582930]
dog	LD50	oral	>10 gm/kg (10000 mg/kg)	Arzneimittel-Forschung. Drug Research., 28(2193), 1978 [PMID:582930]
rabbit	LD50	oral	1250 mg/kg (1250 mg/kg)	Arzneimittel-Forschung. Drug Research., 28(2193), 1978 [PMID:582930]

非班太尔(58306-30-2,Febantel)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Febantel(58306-30-2) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:非班太尔(58306-30-2,Febantel),非班太尔试剂,非班太尔的纯度,非班太尔的价格,非班太尔抑制剂,非班太尔的生产,非班太尔的作用,非班太尔的厂家,非班太尔的含量,非班太尔的使用,非班太尔的杂质,非班太尔的外观,非班太尔的溶解度

产品说明	非班太尔(58306-30-2,Febantel)是一种属于苯并咪唑类化学物质的资深驱虫药。
Introduction	Febantel(58306-30-2):only use for non-medical purposes in industrial or scientific research, and not for clinical diagnosis and treatment of humans or animals. This product is not medicinal or edible.
Application1	非班太尔(58306-30-2,Febantel)用于驱除胃肠道线虫及肺线虫
Application2	非班太尔(58306-30-2,Febantel)用于治疗宠物犬的线虫和绦虫感染
Application3

非班太尔(58306-30-2,Febantel)的合成路线：

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	Febantel实验过程中防止吸入、食入，做好安全防护

Fate of febantel in the aquatic environment—the role of abiotic elimination processes(Environmental Science and Pollution Research,2018)

Determination of Anthelmintic Pharmaceuticals in Wastewater by Solid-Phase Extraction and Thin-Layer Chromatography(JPC – Journal of Planar Chromatography – Modern TLC,2019)

Genetic variation in resistance of the tiger pufferfish Takifugu rubripes to a host-specific monogenean parasite Heterobothrium okamotoi(Fisheries Science,2019)

Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?(Parasites & Vectors,2019)

Urinary incontinence associated with Mesocestoides vogae infection in a dog(Parasitology Research,2019)

1.Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry.
Zrn?i? M1, Gros M2, Babi? S3, Kaštelan-Macan M3, Barcelo D4, Petrovi? M5. Chemosphere. 2014 Mar;99:224-32. doi: 10.1016/j.chemosphere.2013.10.091. Epub 2013 Nov 27.
Abstract:A method based on ultra high performance liquid chromatography coupled to quadrupole linear ion trap mass spectrometry (UHPLC-QqLIT-MS) has been developed to investigate occurrence of 10 anthelmintic drugs from different structural groups (moxidectin, flubendazole, fenbendazole, levamisol, mebendazole, oxibendazole, albendazole, triclabendazole, febantel and praziquantel) in surface water. Analytes were pre-concentrated by solid phase extraction (SPE) using hydrophilic-lipophilic polymeric based sorbent. Quantification of investigated analytes was done using deuterated compounds as internal standards in order to minimize matrix effect. Analyte recoveries from spiked samples at two concentration levels were above 75% for most of the analytes. The main advantages of developed method are fast separation using UHPLC and therefore short analysis time, combined with good sensitivity which is demonstrated by low ngL(-1) detection limits. The developed method was applied for analysis of anthelmintics in the Llobregat River (NE Spain) and its main tributaries (rivers Anoia and Cardener).

2.Case report: protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog.
Tamura Y1, Ohta H2, Kashiide T3, Matsumoto J3, Sakurai T4, Yokoyama N1, Morishita K5, Nakamura K5, Yamasaki M1, Takiguchi M1. Vet Parasitol. 2014 Sep 15;205(1-2):412-5. doi: 10.1016/j.vetpar.2014.07.027. Epub 2014 Aug 2.
Abstract:An eight-year-old, neutered, female Shetland Sheepdog presented with a 6-week history of small intestinal diarrhea. Regenerative anemia, hypoproteinemia, and an increased plasma C-reactive protein concentration were detected on blood examination. Fecal examination and abdominal radiography were unremarkable. Abdominal ultrasonography showed diffusely hyperechoic mucosa in the small intestine. Gastroduodenoscopy, performed under general anesthesia, revealed mucosal edema and increased granularity in the duodenum and jejunum. Histopathological examination of the endoscopically biopsied small intestinal mucosa revealed tapeworm infection. A single administration of a combined anthelmintic drug (5mg/kg praziquantel, 14.4 mg/kg pyrantel pamoate, and 15 mg/kg febantel) was successful for deworming, and the dog fully recovered. The parasites were removed from stored frozen duodenal mucosa and morphologically identified as Mesocestoides sp. immature adult worms.

3.Simultaneous determination of pharmaceuticals and some of their metabolites in wastewaters by high performance liquid chromatography with tandem mass spectrometry.
Periša M1, Babi? S. J Sep Sci. 2014 Jun;37(11):1289-96. doi: 10.1002/jssc.201301135. Epub 2014 Apr 19.
Abstract:The present work describes the development of a sensitive and reliable analytical method based on solid-phase extraction followed by analysis using liquid chromatography with tandem mass spectrometry for the simultaneous determination of pharmaceuticals from antibiotics (fluoroquinolones, sulfonamides, and their N(4)-acetyl metabolites, and trimethoprim as sulfonamides synergist) and anthelmintics groups. SPE was optimized using different cartridges (Strata-X, Oasis HLB, Strata C18 -E, Isolute C18 , SampliQ C8 /Si-SCX). The highest recovery was achieved using Strata X cartridge (>80%) with good reproducibility (RSDs < 5%) despite various physicochemical properties of the compounds. Investigated analytes were identified and quantitatively determined by liquid chromatography with tandem mass spectrometry using multiple reaction monitoring. The method was shown to be linear over the concentration range of 0.05-30 μg/L for febantel and albendazole, and 0.

4.Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry.
Klausz G1, Keller É1, Sára Z2, Székely-Körmöczy P3, Laczay P3, Ary K4, Sótonyi P1, Róna K1. Biomed Chromatogr. 2015 Dec;29(12):1859-65. doi: 10.1002/bmc.3507. Epub 2015 Jun 24.
Abstract:A liquid chromatography-electrospray-mass spectrometry method (LC/MS) has been developed and validated for determination of praziquantel (PZQ), pyrantel (PYR), febantel (FBT), and the active metabolites fenbendazole (FEN) and oxfendazole (OXF), in dog plasma, using mebendazole as internal standard (IS). The method consists of solid-phase extractions on Strata-X polymeric cartridges. Chromatographic separation was carried out on a Phenomenex Gemini C6 -Phenyl column using binary gradient elution containing methanol and 50 mm ammonium-formate (pH 3). The method was linear (r(2) ≥ 0.990) over concentration ranges of 3-250 ng/mL for PYR andFEB, 5-250 ng/mL for OXF and FEN, and 24-1000 ng/mL for PZQ. The mean precisions were 1.3-10.6% (within-run) and 2.5-9.1% (between-run), and mean accuracies were 90.7-109.4% (within-run) and 91.6-108.2% (between-run). The relative standard deviations (RSD) were <9.1%. The mean recoveries of five targeted compounds from dog plasma ranged from 77 to 94%.

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