142128-57-2|Levoketoconazole|(-)-Ketoconazole|-范德生物科技公司

Levoketoconazole

NMR下载 COA and HPLC MSDS下载
names：
(-)-Ketoconazole
CAS号：
142128-57-2
MDL Number：
MF(分子式)： C26H28Cl2N4O4 MW(分子量)： 531.43
EINECS:265-667-4 Reaxys Number:
Pubchem ID:47576 Brand:BIOFOUNT

Levoketoconazole(cas:142128-57-2)是苯基哌嗪的合成衍生物，具有广泛的抗真菌特性和潜在的抗肿瘤活性。Levoketoconazole抑制固醇14-α-二甲基酶（一种微粒体细胞色素P450依赖性酶），从而破坏了麦角固醇（真菌细胞壁的重要组成部分）的合成。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000461-50mg	50mg	99.4%	¥ 3543.00	¥ 3543.00		1-3天	- +	¥ 0.00
YZM000461-10mg	10mg	99.4%	¥ 975.00	¥ 975.00		1-3天	- +	¥ 0.00

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Levoketoconazole(cas:142128-57-2)
英文别名	Levoketoconazole(cas:142128-57-2),(-)-Ketoconazole,Nizoral,ketoconazole, Ketoderm
CAS号	142128-57-2
SMILES	CC(N1CCN(C2=CC=C(OC[C@H]3O[C@](CN4C=CN=C4)(C5=CC=C(Cl)C=C5Cl)OC3)C=C2)CC1)=O
Inchi	InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
InchiKey	XMAYWYJOQHXEEK-ZEQKJWHPSA-N
分子式 Formula	C26H28Cl2N4O4
分子量 Molecular Weight	531.43
闪点 FP	409.4±32.9 °C
熔点 Melting point	No data available
沸点 Boiling point	753.4±60.0 °C at 760 mmHg
Polarizability极化度	55.2±0.5 10-24cm3
密度 Density	1.4±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±2.5 mmHg at 25°C
溶解度Solubility	生物体外In Vitro:DMSO溶解度33.33 mg/mL(62.72 mM;Need ultrasonic)
性状	固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

Levoketoconazole(cas:142128-57-2)毒理性质:

方法	系统	动物	剂量	影响	日期
Mutation Data	DNA Damage	liver/human	1 mmol/l/48H		March 2019
Mutation Data	DNA inhibition	lymphocyte/human	10 mg/L		March 2019
Mutation Data	DNA inhibition	other cell types/human	1 µmol/L		March 2019
Reproductive Effects		oral/man	1029 mg/kg (60D male)	Reproductive: Other effects on male; Endocrine: Androgenic	March 2019
Reproductive Effects		oral/rat	6480 mg/kg (9W male/2W pre-7D pregnant)	Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles); Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	March 2019
Reproductive Effects		oral/rat	600 mg/kg (3D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count); Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	March 2019
Reproductive Effects		oral/rat	3240 mg/kg (9W male/2W pre-7D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea); Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	March 2019
Reproductive Effects		oral/rat	880 mg/kg (7-17D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth); Reproductive: Effects on embryo or fetus: Fetal death; Reproductive: Specific developmental abnormalities: Musculoskeletal system	March 2019
Reproductive Effects		oral/rat	1040 mg/kg (17-21D preg/21D after birth)	Reproductive: Maternal effects: Parturition; Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	March 2019
Reproductive Effects		oral/rat	300 mg/kg (1D male)	Reproductive: Other effects on male	March 2019

(-)-Ketoconazole(CAS:142128-57-2)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Levoketoconazole蒸汽压,Levoketoconazole合成,Levoketoconazole标准,Levoketoconazole应用,Levoketoconazole合成,Levoketoconazole沸点,Levoketoconazole闪点,Levoketoconazole用途,Levoketoconazole溶解度,Levoketoconazole价格,Levoketoconazole作用,Levoketoconazole结构式

产品说明	Levoketoconazole(142128-57-2)（-）-酮康唑（（-）-R 41400）是酮康唑的对映异构体之一。
Introduction	Levoketoconazol(142128-57-2) is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R))etoconazole) and dextroketoconazole ((2R,4S)+)etoconazole).
Application1
Application2
Application3

Levoketoconazole(142128-57-2)-）-酮康唑（（-）-R 41400）是酮康唑的对映异构体之一。酮康唑是两种对映体的外消旋混合物，左酮康唑（（2S，4R）-（）-酮康唑）和右酮康唑（（2R，4S）-（+）-酮康唑）。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护