865285-29-6|KKL-35|KKL-35|MFCD04438597-范德生物科技公司

KKL-35

NMR下载 COA and HPLC MSDS下载
names：
KKL-35
CAS号：
865285-29-6
MDL Number： MFCD04438597
MF(分子式)： C15H9ClFN3O2 MW(分子量)： 317.7
EINECS: Reaxys Number:
Pubchem ID:4128171 Brand:BIOFOUNT

KKL-35(865285-29-6)是一种翻译标记反应抑制剂（IC50 = 0.9 µM），因此可通过阻止核糖体拯救来抑制细菌生长。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000160-1mg	1mg	99.42%	¥ 2925.00	¥ 2925.00		2-3天	- +	¥ 0.00

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中文别名	KKL-35(865285-29-6);KKL-35；KKL 35; KKL35; 4-氯-N- [5-（4-氟苯基）-1,3,4-恶二唑-2-基]苯甲酰胺; F1374-0110；4-氯-N-（5-（4-氟苯基）-1,3,4-恶二唑-2-基）苯甲酰胺;
英文别名	KKL-35(865285-29-6);KKL-35; KKL 35; KKL35; 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide; F1374-0110; 4-chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide;
CAS号	865285-29-6
SMILES	O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)C3=CC=C(Cl)C=C3
Inchi	InChI=1S/C15H9ClFN3O2/c16-11-5-1-9(2-6-11)13(21)18-15-20-19-14(22-15)10-3-7-12(17)8-4-10/h1-8H,(H,18,20,21)
InchiKey	ZIICPNCCHIUJSX-UHFFFAOYSA-N
分子式 Formula	C15H9ClFN3O2
分子量 Molecular Weight	317.7
闪点 FP
熔点 Melting point	No data available
沸点 Boiling point
Polarizability极化度	31.2±0.5 10-24cm3
密度 Density	1.5±0.1 g/cm3
蒸汽压 Vapor Pressure
溶解度Solubility	生物体外In Vitro:DMSO溶解度6.25 mg/mL(19.67 mM;Need ultrasonic)
性状	white to beige powder
储藏条件 Storage conditions	2-8°C，-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

KKL-35(865285-29-6)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:KKL-35试剂,KKL-35杂质,KKL-35中间体,KKL-35密度,KKL-35溶解度,KKL-35抑制剂,KKL-35闪点,KKL-35熔点,KKL-35购买,KKL-35结构式,

产品说明	(865285-29-6)KKL-35是反式标记反应的抑制剂，IC50值是0.9 μM
Introduction	KKL-35(865285-29-6)is atransranslation tagging reactioninhibitor with anIC50of 0.9 μM.
Application1
Application2
Application3

KKL-35(865285-29-6)药理学：

1、KKL-35是反式标记反应抑制剂，IC₅₀额定0.9 µM。

2、KKL-35具有广谱抗生素活性。KKL-35可抑制炭疽芽孢杆菌和耻垢分枝杆菌的生长，其最小抑菌浓度（MIC）值应小于6 µM。在标记蛋白的蛋白水解之前，KKL-35会抑制翻译的某个步骤。KKL-35抑制DHFR-ns的标签。在最高浓度的KKL-35的反应中会产生大量未标记的DHFR，这表明KKL-35不会抑制翻译。WT的KKL-35防止生长弗氏志贺菌以6μM的MIC，并加入KKL-35到的生长培养弗氏志贺菌停止生长。在弗氏链球菌中表达ArfA并缺失ssrA的菌株，添加KKL-35对生存力或生长率几乎没有影响。KKL-35抑制小分子外排不足的大肠杆菌 ?tolC 的生长，MIC为0.3 µM。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

KKL-35(865285-29-6)危害标识：

象形图
信号	Warning
GHS危险说明	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.
	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P264, P270, P301+P312, P330, and P501
防范说明代码	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Ramadoss NS, et al. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7.

KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition PMID 29158279; Antimicrobial agents and chemotherapy 2018 02; 62(2): Name matches: o

A Genetic Tool to Quantify trans-Translation Activity in Vivo PMID 29031699; Journal of molecular biology 2017 11; 429(23):3617-3625 Name matches: smpb kkl-35

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity PMID 23733947; Proceedings of the National Academy of Sciences of the United States of America 2013 Jun; 110(25):

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells PMID 28762275; ACS infectious diseases 2017 09; 3(9):634-644 Name matches: tuberculosis k

KKL-35(865285-29-6)参考文献：

1.A Genetic Tool to Quantify trans-Translation Activity in Vivo.
Macé K;Demay F;Guyomar C;Georgeault S;Giudice E;Goude R;Trautwetter A;Ermel G;Blanco C;Gillet R J Mol Biol. 2017 Nov 24;429(23):3617-3625. doi: 10.1016/j.jmb.2017.10.007. Epub 2017 Oct 13.

In bacteria, trans-translation is the main quality control mechanism for rescuing ribosomes arrested during translation. This key process is universally conserved and plays a critical role in the viability and virulence of many pathogens. We developed a reliable in vivo double-fluorescence reporter system for the simultaneous quantification of both trans-translation and the associated proteolysis activities in bacteria. The assay was validated using mutant bacteria lacking tmRNA, SmpB, and the ClpP protease. Both antisense tmRNA-binding RNA and a peptide mimicking the SmpB C-terminal tail proved to be potent inhibitors of trans-translation in vivo. The double-fluorescent reporter was also tested with KKL-35, an oxadiazole derivative that is supposed to be a promising trans-translation inhibitor, and it surprisingly turns out that trans-translation is not the only target of KKL-35 in vivo.

2.KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of
Brunel R;Descours G;Durieux I;Doublet P;Jarraud S;Charpentier X Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb.

trans;-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit ;trans;-translation have been found to have broad-spectrum antibiotic activity. We sought to determine the activity of KKL-35, a potent member of the oxadiazole family, against the human pathogen ;Legionella pneumophila; and other related species that can also cause Legionnaires' disease (LD). Consistent with the essential nature of ;trans;-translation in ;L. pneumophila;, KKL-35 inhibited the growth of all tested strains at submicromolar concentrations. KKL-35 was also active against other LD-causing ;Legionella; species. KKL-35 remained equally active against ;L. pneumophila; mutants that have evolved resistance to macrolides. KKL-35 inhibited the multiplication of ;L. pneumophila; in human macrophages at several stages of infection. No resistant mutants could be obtained, even during extended and chronic exposure. Surprisingly, KKL-35 was not synergistic with other ribosome-targeting antibiotics and did not induce the filamentation phenotype observed in cells defective for ;trans;-translation. Importantly, KKL-35 remained active against ;L.

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