146731-14-8|Z-335 sodium|sodium 2-(2-(((4-chlorophenyl)sulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetate|-范德生物科技公司

Z-335 sodium

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names：
sodium 2-(2-(((4-chlorophenyl)sulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetate
CAS号：
146731-14-8
MDL Number：
MF(分子式)： C18H17ClNNaO4S MW(分子量)： 401.84
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	sodium 2-(2-(((4-chlorophenyl)sulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetate
英文别名	Z-335; Z335; Z 335
CAS号	146731-14-8
Inchi	InChI=1S/C18H18ClNO4S.Na/c19-16-3-5-17(6-4-16)25(23,24)20-11-13-8-14-2-1-12(10-18(21)22)7-15(14)9-13;/h1-7,13,20H,8-11H2,(H,21,22);/q;+1/p-1
InchiKey	UEPBEZPJELQKJV-UHFFFAOYSA-M
分子式 Formula	C18H17ClNNaO4S
分子量 Molecular Weight	401.84
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Z-335 sodium(CAS:146731-14-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Z-335 Salt is a thromboxane A2 receptor antagonist potentially for the treatment of arterial occlusive disease.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Yoshida M, Sato Y, Shimura T, Ohkubo S, Honma S, Tanaka T, Kurimoto T, Nakahata N. Distinct effects of z-335, a new thromboxane A2 receptor antagonist, on rabbit platelets and aortic smooth muscle. Pharmacology. 2007;79(1):50-6. PubMed PMID: 17139194.

[2]Kawabata Y, Kamada E, Furuta S, Takei M, Kurimoto T, Okudaira K, Nishigaki R. ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles. Pharm Res. 2004 Mar;21(3):467-75. PubMed PMID: 15070098.

[3] Matsuno H, Uematsu T, Niwa M, Kozawa O, Nagashima S, Kohno K, Kato H, Kawabata Y, Yoshida Y, Kanamaru M. Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers. J Clin Pharmacol. 2002 Jul;42(7):782-90. PubMed PMID: 12092745.

[4] Kawabata Y, Nakamura H, Kamada E, Furuta S, Shinozaki Y, Kurimoto T, Nishigaki R. Mechanism of hepatobiliary transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335), and its xenobiotic taurine conjugate (Z-335-Tau) in rats. J Pharm Sci. 2003 Jan;92(1):67-76. PubMed PMID: 12486683.

[5] Kawabata Y, Furuta S, Shinozaki Y, Kurimoto T, Nishigaki R. Carrier-mediated active transport of a novel thromboxane A(2) receptor antagonist [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) into rat liver. Drug Metab Dispos. 2002 May;30(5):498-504. PubMed PMID: 11950778.

6: Tanaka T, Sato R, Kurimoto T. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. PubMed PMID: 10936501.7: Tanaka T, Fukuta Y, Fukuda Y, Higashino R, Ito S, Takei M, Tamaki H, Kurimoto T, Suzuki Y. Z-335, a thromboxane A2 receptor antagonist, suppresses the progression of arachidonic acid-induced hind limb gangrene in rats. Biol Pharm Bull. 1999 Dec;22(12):1382-4. PubMed PMID: 10746175.8: Tanaka T, Fukuta Y, Higashino R, Sato R, Nomura Y, Fukuda Y, Ito S, Takei M, Kurimoto T, Tamaki H. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. PubMed PMID: 9788773.9: Tanaka T, Ito S, Higashino R, Fukuta Y, Fukuda Y, Takei M, Kurimoto T, Tamaki H. A new thromboxane receptor antagonist, Z-335, ameliorates experimental thrombosis without prolonging the rat tail bleeding time. Thromb Res. 1998 Sep 1;91(5):229-35. PubMed PMID: 9755835.10: Saitoh T, Shibayama T. Removal and degradation of β-lactam antibiotics in water using didodecyldimethylammonium bromide-modified montmorillonite organoclay. J Hazard Mater. 2016 Nov 5;317:677-85. doi: 10.1016/j.jhazmat.2016.06.003. PubMed PMID: 27339949.1

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