146731-14-8|Z-335 sodium|sodium 2-(2-(((4-chlorophenyl)sulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetate|-范德生物科技公司

Z-335 sodium

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names：
sodium 2-(2-(((4-chlorophenyl)sulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetate
CAS号：
146731-14-8
MDL Number：
MF(分子式)： C18H17ClNNaO4S MW(分子量)： 401.84
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	sodium 2-(2-(((4-chlorophenyl)sulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetate
英文别名	Z-335; Z335; Z 335
CAS号	146731-14-8
SMILES	O=C([O-])CC1=CC2=C(CC(CNS(=O)(C3=CC=C(Cl)C=C3)=O)C2)C=C1.[Na+]
Inchi	InChI=1S/C18H18ClNO4S.Na/c19-16-3-5-17(6-4-16)25(23,24)20-11-13-8-14-2-1-12(10-18(21)22)7-15(14)9-13;/h1-7,13,20H,8-11H2,(H,21,22);/q;+1/p-1
InchiKey	UEPBEZPJELQKJV-UHFFFAOYSA-M
分子式 Formula	C18H17ClNNaO4S
分子量 Molecular Weight	401.84
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Z-335 sodium(CAS:146731-14-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Z-335 Salt is a thromboxane A2 receptor antagonist potentially for the treatment of arterial occlusive disease.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yoshida M, Sato Y, Shimura T, Ohkubo S, Honma S, Tanaka T, Kurimoto T, Nakahata N. Distinct effects of z-335, a new thromboxane A2 receptor antagonist, on rabbit platelets and aortic smooth muscle. Pharmacology. 2007;79(1):50-6. PubMed PMID: 17139194.

[2]Kawabata Y, Kamada E, Furuta S, Takei M, Kurimoto T, Okudaira K, Nishigaki R. ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles. Pharm Res. 2004 Mar;21(3):467-75. PubMed PMID: 15070098.

[3] Matsuno H, Uematsu T, Niwa M, Kozawa O, Nagashima S, Kohno K, Kato H, Kawabata Y, Yoshida Y, Kanamaru M. Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers. J Clin Pharmacol. 2002 Jul;42(7):782-90. PubMed PMID: 12092745.

[4] Kawabata Y, Nakamura H, Kamada E, Furuta S, Shinozaki Y, Kurimoto T, Nishigaki R. Mechanism of hepatobiliary transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335), and its xenobiotic taurine conjugate (Z-335-Tau) in rats. J Pharm Sci. 2003 Jan;92(1):67-76. PubMed PMID: 12486683.

[5] Kawabata Y, Furuta S, Shinozaki Y, Kurimoto T, Nishigaki R. Carrier-mediated active transport of a novel thromboxane A(2) receptor antagonist [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) into rat liver. Drug Metab Dispos. 2002 May;30(5):498-504. PubMed PMID: 11950778.

6: Tanaka T, Sato R, Kurimoto T. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. PubMed PMID: 10936501.7: Tanaka T, Fukuta Y, Fukuda Y, Higashino R, Ito S, Takei M, Tamaki H, Kurimoto T, Suzuki Y. Z-335, a thromboxane A2 receptor antagonist, suppresses the progression of arachidonic acid-induced hind limb gangrene in rats. Biol Pharm Bull. 1999 Dec;22(12):1382-4. PubMed PMID: 10746175.8: Tanaka T, Fukuta Y, Higashino R, Sato R, Nomura Y, Fukuda Y, Ito S, Takei M, Kurimoto T, Tamaki H. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. PubMed PMID: 9788773.9: Tanaka T, Ito S, Higashino R, Fukuta Y, Fukuda Y, Takei M, Kurimoto T, Tamaki H. A new thromboxane receptor antagonist, Z-335, ameliorates experimental thrombosis without prolonging the rat tail bleeding time. Thromb Res. 1998 Sep 1;91(5):229-35. PubMed PMID: 9755835.10: Saitoh T, Shibayama T. Removal and degradation of β-lactam antibiotics in water using didodecyldimethylammonium bromide-modified montmorillonite organoclay. J Hazard Mater. 2016 Nov 5;317:677-85. doi: 10.1016/j.jhazmat.2016.06.003. PubMed PMID: 27339949.1

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