1381769-23-8|TC-2153 HCl|8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride|-范德生物科技公司

TC-2153 HCl

NMR下载 COA and HPLC MSDS下载
names：
8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
CAS号：
1381769-23-8
MDL Number：
MF(分子式)： C7H5ClF3NS5 MW(分子量)： 355.8692
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
英文别名	TC-2153; TC 2153; TC2153;
CAS号	1381769-23-8
Inchi	InChI=1S/C7H4F3NS5.ClH/c8-7(9,10)3-1-4(11)6-5(2-3)12-14-16-15-13-6;/h1-2H,11H2;1H
InchiKey	PYFSCYSDPQMEGZ-UHFFFAOYSA-N
分子式 Formula	C7H5ClF3NS5
分子量 Molecular Weight	355.8692
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TC-2153 HCl(CAS:1381769-23-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Garcia-Forn M, Martínez-Torres S, Barriga GG, Alberch J, Milà M, Azkona G, Pérez-Navarro E. Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease. Neurobiol Dis. 2018 Aug 3[1]pii: S0969-9961(18)30517-5. doi: 10.1016/j.nbd.2018.08.024. [Epub ahead of print] PubMed PMID: 30176350.

[2]Saavedra A, Ballesteros JJ, Tyebji S, Martínez-Torres S, Blázquez G, López-Hidalgo R, Azkona G, Alberch J, Martín ED, Pérez-Navarro E. Proteolytic Degradation of Hippocampal STEP(61) in LTP and Learning. Mol Neurobiol. 2018 Jun 12. doi: 10.1007/s12035-018-1170-1. [Epub ahead of print] PubMed PMID: 29948948.

[3] Sinyakova NA, Kulikova EA, Englevskii NA, Kulikov AV. Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites. Bull Exp Biol Med. 2018 Mar;164(5):620-623. doi: 10.1007/s10517-018-4045-6. Epub 2018 Mar 26. PubMed PMID: 29577201.

[4] Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Curr Biol. 2018 Apr 2;28(7):1079-1089.e4. doi: 10.1016/j.cub.2018.02.047. Epub 2018 Mar 22. PubMed PMID: 29576474; PubMed Central PMCID: PMC5901906.

[5] Kampshoff CS, van Dongen JM, van Mechelen W, Schep G, Vreugdenhil A, Twisk JWR, Bosmans JE, Brug J, Chinapaw MJM, Buffart LM. Long-term effectiveness and cost-effectiveness of high versus low-to-moderate intensity resistance and endurance exercise interventions among cancer survivors. J Cancer Surviv. 2018 Jun;12(3):417-429. doi: 10.1007/s11764-018-0681-0. Epub 2018 Mar 1. PubMed PMID: 29497963; PubMed Central PMCID: PMC5956032.

6: Chatterjee M, Kurup PK, Lundbye CJ, Hugger Toft AK, Kwon J, Benedict J, Kamceva M, Banke TG, Lombroso PJ. STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice. Neuropharmacology. 2018 Jan;128:43-53. doi: 10.1016/j.neuropharm.2017.09.026. Epub 2017 Sep 21. PubMed PMID: 28943283.7: Kulikova E, Kulikov A. Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders. Curr Protein Pept Sci. 2017 Aug 30;18(11):1152-1162. doi: 10.2174/1389203718666170710121532. Review. PubMed PMID: 28699511.8: Siemsen BM, Lombroso PJ, McGinty JF. Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats. Addict Biol. 2018 Jan;23(1):219-229. doi: 10.1111/adb.12504. Epub 2017 Mar 28. PubMed PMID: 28349660; PubMed Central PMCID: PMC5617773.9: Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ. Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Cell Mol Life Sci. 2016 Apr;73(7):1503-14. doi: 10.1007/s00018-015-2057-1. Epub 2015 Oct 8. PubMed PMID: 26450419; PubMed Central PMCID: PMC4801664.10: Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ. Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels. J Neurochem. 2016 Jan;136(2):285-94. doi: 10.1111/jnc.13295. Epub 2015 Sep 17. PubMed PMID: 26316048; PubMed Central PMCID: PMC4769989.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开