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1820582-41-9
  • Sinoporphyrin sodium

  • names:

    3,3'-(7-(1-(1-(13,17-bis(2-carboxylatoethyl)-3,8,12,18-tetramethyl-7-vinylporphyrin-2-yl)ethoxy)ethyl)-3,8,13,17-tetramethyl-12-vinylporphyrin-2,18-diyl)dipropionate tetrasodium

  • CAS号:

    1820582-41-9

    MDL Number:
  • MF(分子式): C68H66N8Na4O98- MW(分子量): 1231.2865
  • EINECS: Reaxys Number:
  • Pubchem ID: Brand:BIOFOUNT
Sinoporphyrin sodium
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中文别名 3,3'-(7-(1-(1-(13,17-bis(2-carboxylatoethyl)-3,8,12,18-tetramethyl-7-vinylporphyrin-2-yl)ethoxy)ethyl)-3,8,13,17-tetramethyl-12-vinylporphyrin-2,18-diyl)dipropionate tetrasodium
英文别名 Sinoporphyrin sodium; DVDMS; sinoporphyrin; DVDMS Free
CAS号 1820582-41-9
SMILES C=CC1=C(C)/C2=C/C(C(C)=C/3CCC([O-])=O)=NC3=C/C4=C(CCC([O-])=O)C(C)=C(/C=C5C(C(OC(C6=C(C)/C7=C/C8=N/C(C(C)=C8C=C)=C\C9=C(C)C(CCC([O-])=O)=C(/C=C%10C(CCC([O-])=O)=C(C)C(/C=C6\N7)=N/%10)N9)C)C)=C(C)C(/C=C1\N2)=N/5)N4.[Na-].[Na-].[Na-].[Na-]
Inchi InChI=1S/C68H70N8O9.4Na/c1-13-41-31(3)47-23-49-33(5)43(15-19-63(77)78)57(71-49)29-59-45(17-21-65(81)82)35(7)51(73-59)27-61-67(37(9)53(75-61)25-55(41)69-47)39(11)85-40(12)68-38(10)54-26-56-42(14-2)32(4)48(70-56)24-50-34(6)44(16-20-64(79)80)58(72-50)30-60-46(18-22-66(83)84)36(8)52(74-60)28-62(68)76-54;;;;/h13-14,23-30,39-40,69,72-73,76H,1-2,15-22H2,3-12H3,(H,77,78)(H,79,80)(H,81,82)(H,83,84);;;;/q;4*-1/p-4/b47-23-,48-24-,49-23-,50-24-,51-27-,52-28-,53-25-,54-26-,55-25-,56-26-,57-29-,58-30-,59-29-,60-30-,61-27-,62-28-;;;;
InchiKey DVJUUYCXZVLGRJ-FLLOIMQSSA-J
分子式 Formula C68H66N8Na4O98-
分子量 Molecular Weight 1231.2865
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状 Solid powder
储藏条件 Storage conditions Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).
产品说明 Sinoporphyrin sodium(CAS:1820582-41-9 ):仅限应用于工业或者科学研究过程中非医疗目的,不应用于人类或动物的临床诊断以及治过程疗,该产品非药用,非食用。
IntroductionSinoporphyrin sodium, also known as DVDMS, is a photosensitizer that shows potential in both sonodynamic therapy and photodynamic therapy. Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer.
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备注
[1]Shi R, Li C, Jiang Z, Li W, Wang A, Wei J. Preclinical Study of Antineoplastic Sinoporphyrin Sodium-PDT via In Vitro and In Vivo Models. Molecules. 2017 Jan 11;22(1). pii: E112. doi: 10.3390/molecules22010112. PubMed PMID: 28085075.
[2]Shi R, Lin X, Zhang J, Jin H, Wang A, Wei J. Safety evaluation of repeated intravenous infusion of sinoporphyrin with and without PDT in rats. Photochem Photobiol Sci. 2016 Nov 2;15(11):1366-1376. PubMed PMID: 27714312.
[3] Wu L, Wang X, Liu Q, Wingnang Leung A, Wang P, Xu C. Sinoporphyrin sodium mediated photodynamic therapy inhibits the migration associated with collapse of F-actin filaments cytoskeleton in MDA-MB-231 cells. Photodiagnosis Photodyn Ther. 2016 Mar;1
3:58-65. doi: 10.1016/j.pdpdt.2015.12.008. PubMed PMID: 26742781.
[5] Yan X, Niu G, Lin J, Jin AJ, Hu H, Tang Y, Zhang Y, Wu A, Lu J, Zhang S, Huang P, Shen B, Chen X. Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide. Biomaterials. 2015 Feb;4
2:94-102. doi: 10.1016/j.biomaterials.2014.11.040. PubMed PMID: 25542797; PubMed Central PMCID: PMC4280503.
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