126728-71-0|SF 2575|SF 2575|-范德生物科技公司

SF 2575

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names：
SF 2575
CAS号：
126728-71-0
MDL Number：
MF(分子式)： C40H43NO15 MW(分子量)： 777.776
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Benzoic acid, 2-hydroxy-, 3-(aminocarbonyl)-8-(2,6-dideoxy-4-O-(2-methyl-1-oxo-2-butenyl)-beta-D-arabino-hexopyranosyl)-1,4,4a,6,11,11a,12,12a-octahydro-2,5,7-trihydroxy-4a,11-dimethoxy-11-methyl-4,6-dioxo-1-naphthacenyl ester, (1R-(1-alpha,4a-alpha,11-beta,11a-beta,12a-beta))-
英文别名	SF 2575; SF2575; SF-2575
CAS号	126728-71-0
Inchi	InChI=1S/C40H43NO15/c1-7-16(2)37(50)55-32-17(3)54-25(15-24(32)43)19-12-13-20-26(29(19)44)30(45)27-21(39(20,4)52-5)14-22-33(56-38(51)18-10-8-9-11-23(18)42)31(46)28(36(41)49)35(48)40(22,53-6)34(27)47/h7-13,17,21-22,24-25,32-33,42-44,46-47H,14-15H2,1-6H3,(H2,41,49)/b16-7+/t17-,21-,22-,24-,25-,32-,33+,39-,40+/m1/s1
InchiKey	MPBVFNYOBQUJEJ-GNOOZHHESA-N
分子式 Formula	C40H43NO15
分子量 Molecular Weight	777.776
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SF 2575(CAS:126728-71-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SF 2575 is an anticancer tetracycline.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Li L, Wang P, Tang Y. C-glycosylation of anhydrotetracycline scaffold with SsfS6 from the SF2575 biosynthetic pathway. J Antibiot (Tokyo). 2014 Jan;67(1):65-70. doi: 10.1038/ja.2013.88. Epub 2013 Sep 1[1]PubMed PMID: 24022606.

[2]Wang F, Zhou M, Singh S, Yennamalli RM, Bingman CA, Thorson JS, Phillips GN Jr. Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis. Proteins. 2013 Jul;81(7):1277-82. doi: 10.1002/prot.24289. Epub 2013 Apr 20. PubMed PMID: 23526584; PubMed Central PMCID: PMC3896073.

[3] Wang P, Kim W, Pickens LB, Gao X, Tang Y. Heterologous expression and manipulation of three tetracycline biosynthetic pathways. Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11136-40. doi: 10.1002/anie.201205426. Epub 2012 Sep 28. PubMed PMID: 23024027; PubMed Central PMCID: PMC4070387.

[4] Pickens LB, Sawaya MR, Rasool H, Pashkov I, Yeates TO, Tang Y. Structural and biochemical characterization of the salicylyl-acyltranferase SsfX3 from a tetracycline biosynthetic pathway. J Biol Chem. 2011 Dec 2;286(48):41539-51. doi: 10.1074/jbc.M111.299859. Epub 2011 Sep 29. PubMed PMID: 21965680; PubMed Central PMCID: PMC3308865.

[5] Hatsu M, Sasaki T, Gomi S, Kodama Y, Sezaki M, Inouye S, Kondo S. A new tetracycline antibiotic with antitumor activity. II. The structural elucidation of SF2575. J Antibiot (Tokyo). 1992 Mar;45(3):325-30. PubMed PMID: 1577661.

6: Pickens LB, Kim W, Wang P, Zhou H, Watanabe K, Gomi S, Tang Y. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J Am Chem Soc. 2009 Dec 9;131(48):17677-89. doi: 10.1021/ja907852c. PubMed PMID: 19908837; PubMed Central PMCID: PMC2800175.7: Hatsu M, Sasaki T, Watabe H, Miyadoh S, Nagasawa M, Shomura T, Sezaki M, Inouye S, Kondo S. A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575. J Antibiot (Tokyo). 1992 Mar;45(3):320-4. PubMed PMID: 1577660.

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