195068-07-6|Sarizotan HCl|(R)-1-(chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine hydrochloride|-范德生物科技公司

Sarizotan HCl

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names：
(R)-1-(chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine hydrochloride
CAS号：
195068-07-6
MDL Number：
MF(分子式)： C22H22ClFN2O MW(分子量)： 384.88
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(R)-1-(chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine hydrochloride
英文别名	EMD-128130; EMD128130; EMD 128130; EMD-77697; EMD-77697; EMD-77697; Sarizotan hydrochloride; Sarizotan HCl
CAS号	195068-07-6
Inchi	InChI=1S/C22H21FN2O.ClH/c23-20-8-5-17(6-9-20)19-11-16(12-24-14-19)13-25-15-21-10-7-18-3-1-2-4-22(18)26-21;/h1-6,8-9,11-12,14,21,25H,7,10,13,15H2;1H/t21-;/m1./s1
InchiKey	QDLVYMYXOLGZOD-ZMBIFBSDSA-N
分子式 Formula	C22H22ClFN2O
分子量 Molecular Weight	384.88
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sarizotan HCl(CAS:195068-07-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sarizotan, also known as EMD-128130, is a Dopamine D2 receptor partial agonist and Serotonin 1A receptor agonist. Sarizotan exhibits affinity at serotonin and dopamine receptors. Sarizotan effectively suppresses levodopa-induced dyskinesia in primate and rodent models of Parkinson's disease, and tardive dyskinesia in a rodent model. Sarizotan is a full agonist at D3 and D4.4 receptors (EC50=5.6 and 5.4 nM, respectively) but a partial agonist at D2S, D2L and D4.2 receptors (EC50=29, 23 and 4.5 nM, respectively). Sarizotan is an antagonist at D2S and D2L receptors (IC50=52 and 121 nM, respectively). Sarizotan is a full agonist at D2L, D3, D4.2 and D4.4 receptors (EC50=0.51, 0.47, 0.48 and 0.23 nM, respectively) but a partial agonist at D2S receptors (EC50=0.6 nM).
Application1
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危险性	Warning
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备注

[1]Kuzhikandathil EV, Bartoszyk GD. The novel antidyskinetic drug sarizotanelicits different functional responses at human D2-like dopamine receptors.Neuropharmacology. 2006 Sep;51(4):873-84. Epub 2006 Jul 14. PubMed PMID:16844149.

[2]Lorenc-Koci E, Wardas J, Bartoszyk GD, Wolfarth S. Contribution of theserotonin 5-HT1A receptor agonism of 8-OH-DPAT and EMD 128130 to the regulationof haloperidol-induced muscle rigidity in rats. Neuropharmacology. 2003Dec;45(8):1057-69. PubMed PMID: 14614949.

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