159912-58-0|Sabcomeline HCl|(R)-3-Quinuclidineglyoxylonitrile (Z)-O-methyloxime, monohydrochloride|-范德生物科技公司

Sabcomeline HCl

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names：
(R)-3-Quinuclidineglyoxylonitrile (Z)-O-methyloxime, monohydrochloride
CAS号：
159912-58-0
MDL Number：
MF(分子式)： C10H16ClN3O MW(分子量)： 229.708
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(R)-3-Quinuclidineglyoxylonitrile (Z)-O-methyloxime, monohydrochloride
英文别名	Sabcomeline hydrochloride; BCI-224; BRL-55473; CEB-2424; SB-202026A; BCI224; BRL55473; CEB2424; SB202026A. Memric.
CAS号	159912-58-0
SMILES	N#C/C([C@H]1CN2CCC1CC2)=N\OC.[H]Cl
Inchi	InChI=1S/C10H15N3O.ClH/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13;/h8-9H,2-5,7H2,1H3;1H/b12-10+;/t9-;/m0./s1
InchiKey	INJWRVWKJFJRFO-SCRZZQONSA-N
分子式 Formula	C10H16ClN3O
分子量 Molecular Weight	229.708
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sabcomeline HCl(CAS:159912-58-0 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sabcomeline, also known as BCI-224; BRL-55473; CEB-2424; SB-202026A, is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]McArthur RA, Gray J, Schreiber R. Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Curr Opin Investig Drugs. 2010 Jul;11(7):740-60. Review. PubMed PMID: 20571970.

[2]Heinrich JN, Butera JA, Carrick T, Kramer A, Kowal D, Lock T, Marquis KL, Pausch MH, Popiolek M, Sun SC, Tseng E, Uveges AJ, Mayer SC. Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. doi: 10.1016/j.ejphar.2008.12.044. Epub 2009 Jan 11. PubMed PMID: 19168056.

[3] Li Z, Snigdha S, Roseman AS, Dai J, Meltzer HY. Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine. Eur J Pharmacol. 2008 Oct 31;596(1-3):89-97. doi: 10.1016/j.ejphar.2008.08.009. Epub 2008 Aug 22. PubMed PMID: 18771666.

[4] Jones CK, Eberle EL, Shaw DB, McKinzie DL, Shannon HE. Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats. J Pharmacol Exp Ther. 2005 Mar;312(3):1055-63. Epub 2004 Dec 1. PubMed PMID: 15574685.

[5] Balasubramanian A, Ganju RK, Groopman JE. Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes. J Biol Chem. 2003 Sep 12;278(37):35755-66. Epub 2003 Jun 24. PubMed PMID: 12824191.

6: Hosoi R, Kobayashi K, Ishida J, Yamaguchi M, Inoue O. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003 Apr;17(2):123-30. PubMed PMID: 12790361.7: Wienrich M, Meier D, Ensinger HA, Gaida W, Raschig A, Walland A, Hammer R. Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life Sci. 2001 Apr 27;68(22-23):2593-600. PubMed PMID: 11392631.8: Stengel PW, Cohen ML. Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline. J Pharmacol Exp Ther. 2001 Mar;296(3):818-24. PubMed PMID: 11181912.9: Hodges H, Peters S, Gray JA, Hunter AJ. Counteractive effects of a partial (sabcomeline) and a full (RS86) muscarinic receptor agonist on deficits in radial maze performance induced by S-AMPA lesions of the basal forebrain and medial septal area. Behav Brain Res. 1999 Feb 15;99(1):81-92. PubMed PMID: 10512575.10: Wood MD, Murkitt KL, Ho M, Watson JM, Brown F, Hunter AJ, Middlemiss DN. Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br J Pharmacol. 1999 Apr;126(7):1620-4. PubMed PMID: 10323594; PubMed Central PMCID: PMC1565933.1

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