157824-23-2|R-84760 hydrochloride|((S)-5,6-dichloro-2,3-dihydro-1H-inden-1-yl)((R)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride|-范德生物科技公司

R-84760 hydrochloride

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names：
((S)-5,6-dichloro-2,3-dihydro-1H-inden-1-yl)((R)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride
CAS号：
157824-23-2
MDL Number：
MF(分子式)： C19H25Cl3N2OS MW(分子量)： 435.832
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	((S)-5,6-dichloro-2,3-dihydro-1H-inden-1-yl)((R)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride
英文别名	R-84760 hydrochloride; R 84760; R84760; R-86436; R 86436; R86436; R 84761; R-84761; R84761.
CAS号	157824-23-2
SMILES	O=C([C@H]1CCC2=C1C=C(Cl)C(Cl)=C2)N3[C@H](CN4CCCC4)CSCC3.[H]Cl
Inchi	InChI=1S/C19H24Cl2N2OS.ClH/c20-17-9-13-3-4-15(16(13)10-18(17)21)19(24)23-7-8-25-12-14(23)11-22-5-1-2-6-22;/h9-10,14-15H,1-8,11-12H2;1H/t14-,15+;/m1./s1
InchiKey	KSUNRZWFIKXTKO-LIOBNPLQSA-N
分子式 Formula	C19H25Cl3N2OS
分子量 Molecular Weight	435.832
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	R-84760 hydrochloride(CAS:157824-23-2 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	R-84760 is a κ-opioid receptor agonist potentially for the treatment of pain. R-84760 produces an extremely potent antinociceptive effect against tonic pain through the kappa-opioid receptors; the sites of action of subcutaneously administered R-84760 are the supraspinal and spinal loci in the central nervous system; and a part of the mechanism of the antinociceptive effect of R-84760 is activation of the descending noradrenergic pathway.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ohsawa M, Kamei J. Modification of kappa-opioid receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord. J Pharmacol Sci. 2005 May;98(1):25-32. PubMed PMID: 15879680.

[2]Mori T, Nomura M, Yoshizawa K, Nagase H, Narita M, Suzuki T. Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats. Life Sci. 2004 Oct 1;75(20):2473-82. PubMed PMID: 15350822.

[3] Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl). 2004 Apr;173(1-2):146-52. PubMed PMID: 14712342.

[4] Kobayashi N, Kazui M, Ikeda T. Rapid, real-time sampling of R-84760 in blood by in vivo microdialysis with tandem mass spectrometry. J Pharm Biomed Anal. 2000 Jan;21(6):1233-42. PubMed PMID: 10708407.

[5] Kobayashi N, Naganuma H. Quantitative analysis of R-84760, a selective kappa-opioid receptor agonist, in plasma by liquid chromatography with electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 1999 May;19(6):829-36. PubMed PMID: 10698548.

6: Fujibayashi K, Kubota K, Saito K. Effects of R-84760, a selective kappa-opioid receptor agonist, on nociceptive reflex in isolated neonatal rat spinal cord. Eur J Pharmacol. 1998 Feb 19;343(2-3):171-7. PubMed PMID: 9570465.7: Fujibayashi K, Kubota-Watanabe M, Iizuka Y. Effects of R-84760, a selective kappa-opioid receptor agonist, on nociception, locomotion and respiration in rats. Arch Int Pharmacodyn Ther. 1996 Mar-Apr;331(2):153-62. PubMed PMID: 8937626.8: Fujibayashi K, Iizuka Y. Profiles of the antinociceptive effect of R-84760, a selective kappa-opioid receptor agonist, in the formalin test in mice. Jpn J Pharmacol. 1995 May;68(1):57-63. PubMed PMID: 7494383.9: Fujibayashi K, Sakamoto K, Watanabe M, Iizuka Y. Pharmacological properties of R-84760, a novel kappa-opioid receptor agonist. Eur J Pharmacol. 1994 Aug 11;261(1-2):133-40. PubMed PMID: 8001635.

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