157824-23-2|R-84760 hydrochloride|((S)-5,6-dichloro-2,3-dihydro-1H-inden-1-yl)((R)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride|-范德生物科技公司

R-84760 hydrochloride

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names：
((S)-5,6-dichloro-2,3-dihydro-1H-inden-1-yl)((R)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride
CAS号：
157824-23-2
MDL Number：
MF(分子式)： C19H25Cl3N2OS MW(分子量)： 435.832
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	((S)-5,6-dichloro-2,3-dihydro-1H-inden-1-yl)((R)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride
英文别名	R-84760 hydrochloride; R 84760; R84760; R-86436; R 86436; R86436; R 84761; R-84761; R84761.
CAS号	157824-23-2
Inchi	InChI=1S/C19H24Cl2N2OS.ClH/c20-17-9-13-3-4-15(16(13)10-18(17)21)19(24)23-7-8-25-12-14(23)11-22-5-1-2-6-22;/h9-10,14-15H,1-8,11-12H2;1H/t14-,15+;/m1./s1
InchiKey	KSUNRZWFIKXTKO-LIOBNPLQSA-N
分子式 Formula	C19H25Cl3N2OS
分子量 Molecular Weight	435.832
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	R-84760 hydrochloride(CAS:157824-23-2 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	R-84760 is a κ-opioid receptor agonist potentially for the treatment of pain. R-84760 produces an extremely potent antinociceptive effect against tonic pain through the kappa-opioid receptors; the sites of action of subcutaneously administered R-84760 are the supraspinal and spinal loci in the central nervous system; and a part of the mechanism of the antinociceptive effect of R-84760 is activation of the descending noradrenergic pathway.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Ohsawa M, Kamei J. Modification of kappa-opioid receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord. J Pharmacol Sci. 2005 May;98(1):25-32. PubMed PMID: 15879680.

[2]Mori T, Nomura M, Yoshizawa K, Nagase H, Narita M, Suzuki T. Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats. Life Sci. 2004 Oct 1;75(20):2473-82. PubMed PMID: 15350822.

[3] Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl). 2004 Apr;173(1-2):146-52. PubMed PMID: 14712342.

[4] Kobayashi N, Kazui M, Ikeda T. Rapid, real-time sampling of R-84760 in blood by in vivo microdialysis with tandem mass spectrometry. J Pharm Biomed Anal. 2000 Jan;21(6):1233-42. PubMed PMID: 10708407.

[5] Kobayashi N, Naganuma H. Quantitative analysis of R-84760, a selective kappa-opioid receptor agonist, in plasma by liquid chromatography with electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 1999 May;19(6):829-36. PubMed PMID: 10698548.

6: Fujibayashi K, Kubota K, Saito K. Effects of R-84760, a selective kappa-opioid receptor agonist, on nociceptive reflex in isolated neonatal rat spinal cord. Eur J Pharmacol. 1998 Feb 19;343(2-3):171-7. PubMed PMID: 9570465.7: Fujibayashi K, Kubota-Watanabe M, Iizuka Y. Effects of R-84760, a selective kappa-opioid receptor agonist, on nociception, locomotion and respiration in rats. Arch Int Pharmacodyn Ther. 1996 Mar-Apr;331(2):153-62. PubMed PMID: 8937626.8: Fujibayashi K, Iizuka Y. Profiles of the antinociceptive effect of R-84760, a selective kappa-opioid receptor agonist, in the formalin test in mice. Jpn J Pharmacol. 1995 May;68(1):57-63. PubMed PMID: 7494383.9: Fujibayashi K, Sakamoto K, Watanabe M, Iizuka Y. Pharmacological properties of R-84760, a novel kappa-opioid receptor agonist. Eur J Pharmacol. 1994 Aug 11;261(1-2):133-40. PubMed PMID: 8001635.

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