146999-93-1|PYX 2|PYX 2|-范德生物科技公司

PYX 2

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names：
PYX 2
CAS号：
146999-93-1
MDL Number：
MF(分子式)： C77H108Cl4N18O17 MW(分子量)： 1699.62
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(2S,5S,8S,11S,14R,17S,20S,23S,26S,29S)-23-(2-amino-2-oxoethyl)-8-(3-amino-3-oxopropyl)-17,26-di((S)-sec-butyl)-2,29-bis(3-(2,6-dichlorobenzyl)-4-hydroxybenzyl)-5,11-bis(3-guanidinopropyl)-14-((S)-1-hydroxyethyl)-20-isobutyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazadotriacontanoic acid
英文别名	PYX 2; PYX-2; PYX2;
CAS号	146999-93-1
Inchi	InChI=1S/C77H108Cl4N18O17/c1-9-38(5)63(97-71(111)56(90-41(8)101)32-42-21-24-59(102)44(30-42)34-46-48(78)15-11-16-49(46)79)72(112)95-57(36-62(83)105)69(109)94-55(29-37(3)4)70(110)98-64(39(6)10-2)73(113)99-65(40(7)100)74(114)93-53(20-14-28-89-77(86)87)66(106)92-54(23-26-61(82)104)68(108)91-52(19-13-27-88-76(84)85)67(107)96-58(75(115)116)33-43-22-25-60(103)45(31-43)35-47-50(80)17-12-18-51(47)81/h11-12,15-18,21-22,24-25,30-31,37-40,52-58,63-65,100,102-103H,9-10,13-14,19-20,23,26-29,32-36H2,1-8H3,(H2,82,104)(H2,83,105)(H,90,101)(H,91,108)(H,92,106)(H,93,114)(H,94,109)(H,95,112)(H,96,107)(H,97,111)(H,98,110)(H,99,113)(H,115,116)(H4,84,85,88)(H4,86,87,89)/t38-,39-,40-,52-,53-,54-,55-,56-,57-,58-,63-,64-,65+/m0/s1
InchiKey	ZAQGGXGNZHMCAL-JPXADNNBSA-N
分子式 Formula	C77H108Cl4N18O17
分子量 Molecular Weight	1699.62
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	PYX 2(CAS:146999-93-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	PYX 2 is a neuropeptide Y receptor antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Palea S, Corsi M, Rimland JM, Trist DG, Ratti E. Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens. Br J Pharmacol. 1995 Nov;116(5):2401-6. PubMed PMID: 8581275; PubMed Central PMCID: PMC1909051.

[2]Leibowitz SF, Xuereb M, Kim T. Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2. Neuroreport. 1992 Nov;3(11):1023-6. PubMed PMID: 1482761.

[3] Beck B, Stricker-Krongrad A, Musse N, Nicolas JP, Burlet C. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats. Neurosci Lett. 1994 Nov 7;181(1-2):126-8. PubMed PMID: 7898751.

[4] Lee MC, Lawson DC, Pappas TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept. 1994 Aug 4;52(3):227-34. PubMed PMID: 7800854.

[5] Wieland HA, Willim KD, Entzeroth M, Wienen W, Rudolf K, Eberlein W, Engel W, Doods HN. Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226. J Pharmacol Exp Ther. 1995 Oct;275(1):143-9. PubMed PMID: 7562543.

6: Smith-White M, Moriarty MJ, Potter EK. A comparison of actions of neuropeptide Y (NPY) agonists and antagonists at NPY Y1 and Y2 receptors in anaesthetized rats. Neuropeptides. 1998 Apr;32(2):109-18. PubMed PMID: 9639248.7: Crowley WR, Ramoz G, Hurst B. Evidence for involvement of neuropeptide Y and melanocortin systems in the hyperphagia of lactation in rats. Pharmacol Biochem Behav. 2003 Jan;74(2):417-24. PubMed PMID: 12479963.8: Oellerich WF, Malik KU. Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1993 Sep;266(3):1321-9. PubMed PMID: 8371140.

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