1303420-67-8|PLX5622 free base|6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine|-范德生物科技公司

PLX5622 free base

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names：
6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine
CAS号：
1303420-67-8
MDL Number：
MF(分子式)： C21H19F2N5O MW(分子量)： 395.4138
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine
英文别名	PLX5622; PLX-5622; PLX 5622;
CAS号	1303420-67-8
Inchi	InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
InchiKey	NSMOZFXKTHCPTQ-UHFFFAOYSA-N
分子式 Formula	C21H19F2N5O
分子量 Molecular Weight	395.4138
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	PLX5622 free base(CAS:1303420-67-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. PLX5622 has been shown to eliminate microglia from the brain, which can be sustained in wild-type and the Alzheimer's disease model mice (3xTg-AD model). In the AD model PLX5622 prevents microglial association with amyloid β plaques and improves cognition.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Spangenberg E, Severson PL, Hohsfield LA, Crapser J, Zhang J, Burton EA, Zhang Y, Spevak W, Lin J, Phan NY, Habets G, Rymar A, Tsang G, Walters J, Nespi M, Singh P, Broome S, Ibrahim P, Zhang C, Bollag G, West BL, Green KN. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758. doi: 10.1038/s41467-019-11674-z. PubMed PMID: 31434879; PubMed Central PMCID: PMC6704256.

[2]Hutchinson JM, Isaacson LG. Elimination of microglia in mouse spinal cord alters the retrograde CNS plasticity observed following peripheral axon injury. Brain Res. 2019 Oct 15;1721:146328. doi: 10.1016/j.brainres.2019.146328. Epub 2019 Jul 8. PubMed PMID: 31295468.

[3] Todd L, Palazzo I, Suarez L, Liu X, Volkov L, Hoang TV, Campbell WA, Blackshaw S, Quan N, Fischer AJ. Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina. J Neuroinflammation. 2019 Jun 6;16(1):118. doi: 10.1186/s12974-019-1505-5. PubMed PMID: 31170999; PubMed Central PMCID: PMC6555727.

[4] Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, Martens H, Weber MS, Boretius S, Nave KA, Ehrenreich H. Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion. FASEB J. 2019 Jul;33(7):8634-8647. doi: 10.1096/fj.201900337R. Epub 2019 May 15. PubMed PMID: 31090455.

[5] Lehmann ML, Weigel TK, Poffenberger CN, Herkenham M. The Behavioral Sequelae of Social Defeat Require Microglia and Are Driven by Oxidative Stress in Mice. J Neurosci. 2019 Jul 10;39(28):5594-5605. doi: 10.1523/JNEUROSCI.0184-19.2019. Epub 2019 May 13. PubMed PMID: 31085604; PubMed Central PMCID: PMC6616288.

6: Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 Aug;318:32-41. doi: 10.1016/j.expneurol.2019.04.011. Epub 2019 Apr 25. PubMed PMID: 31029597; PubMed Central PMCID: PMC6615458.7: Kyle J, Wu M, Gourzi S, Tsirka SE. Proliferation and Differentiation in the Adult Subventricular Zone Are Not Affected by CSF1R Inhibition. Front Cell Neurosci. 2019 Apr 2;1

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