109293-20-1|Lu49888 HCl|Benzeneacetonitrile, alpha-(3-((2-(3-azidophenyl)ethyl)methyl-amino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (-)-|-范德生物科技公司

Lu49888 HCl

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names：
Benzeneacetonitrile, alpha-(3-((2-(3-azidophenyl)ethyl)methyl-amino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (-)-
CAS号：
109293-20-1
MDL Number：
MF(分子式)： C26H36ClN5O3 MW(分子量)： 502.056
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lu49888 HCl
英文别名	LU 49888; LU49888; LU-49888; Azidopamil; Ludopamil
CAS号	109293-20-1
SMILES	N#CC(C(C)C)(CCCN(CCC1=CC=CC(N=[N+]=[N-])=C1)C)C2=CC(OC)=C(OC)C(OC)=C2.[H]Cl
Inchi	InChI=1S/C26H35N5O3.ClH/c1-19(2)26(18-27,21-16-23(32-4)25(34-6)24(17-21)33-5)12-8-13-31(3)14-11-20-9-7-10-22(15-20)29-30-28;/h7,9-10,15-17,19H,8,11-14H2,1-6H3;1H
InchiKey	ZUNFHPIYIPQTIE-UHFFFAOYSA-N
分子式 Formula	C26H36ClN5O3
分子量 Molecular Weight	502.056
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lu49888 HCl(CAS:109293-20-1 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	LU 49888 is a photoaffinity analog of verapamil that has been used to identify specific binding sites for phenylalkylamines of calcium channels present in rabbit skeletal muscle microsomes.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sieber M, Nastainczyk W, Zubor V, Wernet W, Hofmann F. The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel. Eur J Biochem. 1987 Aug 17;167(1):117-22. PubMed PMID: 2441986.

[2]Striessnig J, Knaus HG, Grabner M, Moosburger K, Seitz W, Lietz H, Glossmann H. Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel. FEBS Lett. 1987 Feb 23;212(2):247-53. PubMed PMID: 2434359.

[3] Qian XD, Beck WT. Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines. Cancer Res. 1990 Feb 15;50(4):1132-7. PubMed PMID: 1967551.

[4] Striessnig J, Glossmann H, Catterall WA. Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9108-12. PubMed PMID: 2174553; PubMed Central PMCID: PMC55113.

[5] Zernig G. Photoaffinity labeling of the partially purified mitochondrial phenylalkylamine calcium antagonist receptor. Mol Pharmacol. 1992 Dec;42(6):1010-3. PubMed PMID: 1336110.

6: Striessnig J, Knaus HG, Glossmann H. Photoaffinity-labelling of the calcium-channel-associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea-pig hippocampus. A 195 kDa polypeptide carries both drug receptors and has similarities to the alpha 1 subunit of the purified skeletal-muscle calcium channel. Biochem J. 1988 Jul 1;253(1):39-47. PubMed PMID: 2844171; PubMed Central PMCID: PMC1149255.7: Wernet W, Sieber M, Landgraf W, Hofmann F. Rabbit skeletal muscle microsomes contain two distinct phenylalkylamine-binding sites. Eur J Biochem. 1988 Feb 15;172(1):233-8. PubMed PMID: 2450023.8: Flockerzi V. Molecular properties of voltage-activated calcium channels. J Protein Chem. 1989 Jun;8(3):428-30. PubMed PMID: 2477023.9: Moebius FF, Burrows GG, Hanner M, Schmid E, Striessnig J, Glossmann H. Identification of a 27-kDa high affinity phenylalkylamine-binding polypeptide as the sigma 1 binding site by photoaffinity labeling and ligand-directed antibodies. Mol Pharmacol. 1993 Nov;44(5):966-71. PubMed PMID: 8246920.

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