126586-85-4|Liga 20|Liga 20|-范德生物科技公司

Liga 20

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names：
Liga 20
CAS号：
126586-85-4
MDL Number：
MF(分子式)： C57H97Cl2N3O31 MW(分子量)： 1391.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2S,4R,5R,6S)-5-acetamido-2-(((2R,3S,4R,5S,6R)-3-(((2S,3S,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-(((2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,4R,5S,6R)-6-(((2R,3S,E)-2-(2,2-dichloroacetamido)-3-hydroxyoctadec-4-en-1-yl)oxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-5-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid
英文别名	Liga 20; Liga-20; Liga20;
CAS号	126586-85-4
Inchi	InChI=1S/C57H97Cl2N3O31/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(70)27(62-51(81)50(58)59)24-84-53-43(79)41(77)45(33(22-66)87-53)89-55-44(80)49(93-57(56(82)83)18-29(71)35(60-25(2)68)48(92-57)37(73)30(72)19-63)46(34(23-67)88-55)90-52-36(61-26(3)69)47(39(75)32(21-65)85-52)91-54-42(78)40(76)38(74)31(20-64)86-54/h16-17,27-50,52-55,63-67,70-80H,4-15,18-24H2,1-3H3,(H,60,68)(H,61,69)(H,62,81)(H,82,83)/b17-16+/t27-,28+,29-,30-,31-,32-,33-,34-,35-,36+,37-,38+,39+,40+,41-,42+,43+,44+,45+,46+,47-,48+,49-,52+,53-,54-,55-,57+/m1/s1
InchiKey	CQCBGDOXLXRPIU-XXDAVWNGSA-N
分子式 Formula	C57H97Cl2N3O31
分子量 Molecular Weight	1391.29
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Liga 20(CAS:126586-85-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Liga 20 is a semisynthetic GM1 ganglioside with N-dichloroacetylsphingosine; about ten times more potent than the natural GM2 in protecting neurons in culture against glutamate toxicity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Schneider JS, DiStefano L. LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment. Neuroreport. 1993 Nov 18;5(2):103-4. PubMed PMID: 8110995.

[2]Wu G, Lu ZH, Wang J, Wang Y, Xie X, Meyenhofer MF, Ledeen RW. Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci. 2005 Nov 23;25(47):11014-22. PubMed PMID: 16306414.

[3] Wu G, Lu ZH, Xie X, Li L, Ledeen RW. Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. J Neurochem. 2001 Feb;76(3):690-702. PubMed PMID: 11158239.

[4] Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan;26

[5]177-89. doi: 10.1016/j.expneurol.2014.10.010. Epub 2014 Oct 23. PubMed PMID: 25448159.

5: Schneider JS, Distefano L. Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion. Neuropharmacology. 1995 May;34(5):489-93. PubMed PMID: 7566482.

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