126586-85-4|Liga 20|Liga 20|-范德生物科技公司

Liga 20

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names：
Liga 20
CAS号：
126586-85-4
MDL Number：
MF(分子式)： C57H97Cl2N3O31 MW(分子量)： 1391.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK17639-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	(2S,4R,5R,6S)-5-acetamido-2-(((2R,3S,4R,5S,6R)-3-(((2S,3S,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-(((2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,4R,5S,6R)-6-(((2R,3S,E)-2-(2,2-dichloroacetamido)-3-hydroxyoctadec-4-en-1-yl)oxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-5-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid
英文别名	Liga 20; Liga-20; Liga20;
CAS号	126586-85-4
SMILES	CC(N[C@@H]1[C@H](O)C[C@@](O[C@@H]1[C@H](O)[C@H](O)CO)(C(O)=O)O[C@@H]2[C@H](O)[C@H](O[C@H](CO)[C@@H]2O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4[C@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)[C@@H]3NC(C)=O)O[C@@H]5[C@H](O)[C@H](O)[C@H](OC[C@H]([C@H](/C=C/CCCCCCCCCCCCC)O)NC(C(Cl)Cl)=O)O[C@@H]5CO)=O
Inchi	InChI=1S/C57H97Cl2N3O31/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(70)27(62-51(81)50(58)59)24-84-53-43(79)41(77)45(33(22-66)87-53)89-55-44(80)49(93-57(56(82)83)18-29(71)35(60-25(2)68)48(92-57)37(73)30(72)19-63)46(34(23-67)88-55)90-52-36(61-26(3)69)47(39(75)32(21-65)85-52)91-54-42(78)40(76)38(74)31(20-64)86-54/h16-17,27-50,52-55,63-67,70-80H,4-15,18-24H2,1-3H3,(H,60,68)(H,61,69)(H,62,81)(H,82,83)/b17-16+/t27-,28+,29-,30-,31-,32-,33-,34-,35-,36+,37-,38+,39+,40+,41-,42+,43+,44+,45+,46+,47-,48+,49-,52+,53-,54-,55-,57+/m1/s1
InchiKey	CQCBGDOXLXRPIU-XXDAVWNGSA-N
分子式 Formula	C57H97Cl2N3O31
分子量 Molecular Weight	1391.29
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Liga 20(CAS:126586-85-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Liga 20 is a semisynthetic GM1 ganglioside with N-dichloroacetylsphingosine; about ten times more potent than the natural GM2 in protecting neurons in culture against glutamate toxicity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Schneider JS, DiStefano L. LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment. Neuroreport. 1993 Nov 18;5(2):103-4. PubMed PMID: 8110995.

[2]Wu G, Lu ZH, Wang J, Wang Y, Xie X, Meyenhofer MF, Ledeen RW. Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci. 2005 Nov 23;25(47):11014-22. PubMed PMID: 16306414.

[3] Wu G, Lu ZH, Xie X, Li L, Ledeen RW. Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. J Neurochem. 2001 Feb;76(3):690-702. PubMed PMID: 11158239.

[4] Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan;26

[5]177-89. doi: 10.1016/j.expneurol.2014.10.010. Epub 2014 Oct 23. PubMed PMID: 25448159.

5: Schneider JS, Distefano L. Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion. Neuropharmacology. 1995 May;34(5):489-93. PubMed PMID: 7566482.

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