627891-34-3|Levonadifloxacin Arginine Salt|L-arginine compound with (S)-9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid (11) hydrate|-范德生物科技公司

Levonadifloxacin Arginine Salt

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names：
L-arginine compound with (S)-9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid (11) hydrate
CAS号：
627891-34-3
MDL Number：
MF(分子式)： C25H37FN6O7 MW(分子量)： 552.6
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Levonadifloxacin Arginine Salt
英文别名	WCK-771A; WCK-771; WCK771A; WCK771; WCK 771A; WCK 771
CAS号	627891-34-3
SMILES	N[C@@H](CCCNC(N)=N)C(O)=O.O=C(C1=CN2[C@@H](C)CCC3=C2C(C1=O)=CC(F)=C3N4CCC(O)CC4)O.[H]O[H]
Inchi	InChI=1S/C19H21FN2O4.C6H14N4O2.H2O/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21;7-4(5(11)12)2-1-3-10-6(8)9;/h8-11,23H,2-7H2,1H3,(H,25,26);4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H2/t10-;4-;/m00./s1
InchiKey	LPJMHPRTAJJWOG-JSYSIMMRSA-N
分子式 Formula	C25H37FN6O7
分子量 Molecular Weight	552.6
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Levonadifloxacin Arginine Salt(CAS:627891-34-3 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Levonadifloxacin is a broad-spectrum fluoroquinolone antibiotic potentially for the treatment of staphylococci.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bhagwat SS, Mundkur LA, Gupte SV, Patel MV, Khorakiwala HF. The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA gyrase. Antimicrob Agents Chemother. 2006 Nov;50(11):3568-79. PubMed PMID: 16940059; PubMed Central PMCID: PMC1635177.

[2]Appelbaum PC, Pankuch GA, Bozdogan B, Lin G, Jacobs MR, Patel MV, Gupte SV, Jafri MA, De Souza NJ, Khorakiwala HF. Activity of the new quinolone WCK 771 against pneumococci. Clin Microbiol Infect. 2005 Jan;11(1):9-14. PubMed PMID: 15649298.

[3] Patel MV, De Souza NJ, Gupte SV, Jafri MA, Bhagwat SS, Chugh Y, Khorakiwala HF, Jacobs MR, Appelbaum PC. Antistaphylococcal activity of WCK 771, a tricyclic fluoroquinolone, in animal infection models. Antimicrob Agents Chemother. 2004 Dec;48(12):4754-61. PubMed PMID: 15561853; PubMed Central PMCID: PMC529196.

[4] Jacobs MR, Bajaksouzian S, Windau A, Appelbaum PC, Patel MV, Gupte SV, Bhagwat SS, De Souza NJ, Khorakiwala HF. In vitro activity of the new quinolone WCK 771 against staphylococci. Antimicrob Agents Chemother. 2004 Sep;48(9):3338-42. PubMed PMID: 15328094; PubMed Central PMCID: PMC514757.

[5] Yeole RD, Jadhav AS, Patil KR, Rane VP, Kubal ML, Singh S, Patel MV, Khorakiwala HF. Validated chiral high-performance liquid chromatography method for a novel anti-methicillin-resistant Staphylococcus aureus fluoroquinolone WCK 771. J Chromatogr A. 2006 Mar 3;1108(1):38-42. PubMed PMID: 16426621.

6: Yeole RD, Kulkarni VL, Latad SB, Chavan RP, Chugh Y, Patel MV, Khorakiwala HF. Simple liquid chromatography-tandem mass spectrometry method for determination of novel anti-methicillin-resistant Staphylococcus aureus fluoroquinolone WCK 771 in human serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):306-12. PubMed PMID: 17027349.7: Bhagwat SS, McGhee P, Kosowska-Shick K, Patel MV, Appelbaum PC. In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types. Antimicrob Agents Chemother. 2009 Feb;53(2):811-3. doi: 10.1128/AAC.01150-08. Erratum in: Antimicrob Agents Chemother. 2009 Mar;53(3):1298. PubMed PMID: 19029326; PubMed Central PMCID: PMC2630593.8: Al-Lahham A, De Souza NJ, Patel M, René Reinert R. Activity of the new quinolones WCK 771, WCK 1152 and WCK 1153 against clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes. J Antimicrob Chemother. 2005 Dec;56(6):1130-3. PubMed PMID: 16239291.9: Peric M, Jacobs MR, Appelbaum PC. Antianaerobic activity of a novel fluoroquinolone, WCK 771, compared to those of nine other agents. Antimicrob Agents Chemother. 2004 Aug;48(8):3188-92. PubMed PMID: 15273148; PubMed Central PMCID: PMC478502.10: Jacobs MR, Appelbaum PC. Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother. 2006 Oct;7(14):1957-66. Review. PubMed PMID: 17020421.1

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