86315-52-8|Isomazole|2-(2-Methoxy-4-methylsulfinylphenyl)-3H-imidazo[4,5-c]pyridine|-范德生物科技公司

Isomazole

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names：
2-(2-Methoxy-4-methylsulfinylphenyl)-3H-imidazo[4,5-c]pyridine
CAS号：
86315-52-8
MDL Number：
MF(分子式)： C14H13N3O2S MW(分子量)： 287.337
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Isomazole
英文别名	Isomazole
CAS号	86315-52-8
SMILES	O=S(C1=CC=C(C(N2)=NC3=C2C=NC=C3)C(OC)=C1)C
Inchi	InChI=1S/C14H13N3O2S/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14/h3-8H,1-2H3,(H,16,17)
InchiKey	JQUKCPUPFALELS-UHFFFAOYSA-N
分子式 Formula	C14H13N3O2S
分子量 Molecular Weight	287.337
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Isomazole(CAS:86315-52-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Isomazole is a potent inotropic agent, inhibiting both PDE3 and PDE4.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Utkan T, Yildirim MK, Yildirim S, Sarioglu Y. Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro. Int J Impot Res. 2001 Feb;13(1):24-30. PubMed PMID: 11313837.

[3] Dorigo P, Floreani M, Santostasi G, Maragno I, Danieli-Betto D, Germinario E, Magno SM, Primofiore G, Marini AM, Da Settimo F. Pharmacological characterization of a new Ca(2+) sensitizer. J Pharmacol Exp Ther. 2000 Dec;295(3):994-1004. PubMed PMID: 11082434.

[4] Andreani A, Leoni A, Morigi R, Bossa R, Chiericozzi M, Galatulas I. In vivo cardiotonic activity of aryl- and pyridyl-substituted fused imidazoles. Arzneimittelforschung. 1998 Mar;48(3):232-5. PubMed PMID: 9553678.

[5] Van der Ent M, Remme WJ, Bartels GL, De Leeuw PW, Van Hoogenhuyze DC, Kruijssen DA. Contrasting preload-dependent hemodynamic and neurohumoral effects of isomazole, a partial phosphodiesterase inhibitor and calcium sensitizer. J Card Fail. 1997 Dec;3(4):277-86. PubMed PMID: 9547442.

6: De Mey C, Erb K, Schroeter V, Belz GG. Differentiation of inodilatory responses by non-invasive measures of cardiovascular performance in healthy man. Int J Clin Pharmacol Ther. 1996 Dec;34(12):525-32. PubMed PMID: 8996846.7: Hata K, Goto Y, Futaki S, Takasago T, Saeki A, Nishioka T, Suga H. Effects of milrinone and sulmazole on left ventricular mechanoenergetics in canine hearts. J Card Fail. 1996 Sep;2(3):203-13. PubMed PMID: 8891859.8: Bossa R, Bissoli M, Chiericozzi M, Cozzi R, Galatulas I, Salvatore G. Reduction of adriamycin cardiotoxicity by enoximone. Anticancer Res. 1996 Jan-Feb;16(1):141-3. PubMed PMID: 8615599.9: De Mey C. Method specificity of the auscultatory estimates of the inodilatory reduction of diastolic blood pressure based on Korotkoff IV and V criteria. Br J Clin Pharmacol. 1995 May;39(5):485-90. PubMed PMID: 7669483; PubMed Central PMCID: PMC1365054.10: Kelso EJ, McDermott BJ, Silke B. Actions of the novel vasodilator, flosequinan, in isolated ventricular cardiomyocytes. J Cardiovasc Pharmacol. 1995 Mar;25(3):376-86. PubMed PMID: 7769801.1

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