642407-63-4|Iptakalim Hydrochloride|N-(1-methylethyl)-1,1,2-trimethylpropylamine hydrochloride|-范德生物科技公司

Iptakalim Hydrochloride

NMR下载 COA and HPLC MSDS下载
names：
N-(1-methylethyl)-1,1,2-trimethylpropylamine hydrochloride
CAS号：
642407-63-4
MDL Number：
MF(分子式)： C9H22ClN MW(分子量)： 179.732
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Iptakalim Hydrochloride
英文别名	Iptakalim Hydrochloride
CAS号	642407-63-4
Inchi	InChI=1S/C9H21N.ClH/c1-7(2)9(5,6)10-8(3)4;/h7-8,10H,1-6H3;1H
InchiKey	RXNJQAYLNOXYKW-UHFFFAOYSA-N
分子式 Formula	C9H22ClN
分子量 Molecular Weight	179.732
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Iptakalim Hydrochloride(CAS:642407-63-4 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Iptakalim is a K(ir) 6.1/SUR2B activator potentially for the treatment of pulmonary arterial hypertension. Iptakalim inhibits PDGF-BB-induced human airway smooth muscle cells proliferation and migration. Iptakalim attenuates hypoxia-induced pulmonary arterial hypertension in rats by endothelial function protection. Iptakalim influences the proliferation and apoptosis of human pulmonary artery smooth muscle cells. Iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Li Q, Yan X, Kong H, Xie W, Wang H. Iptakalim influences the proliferation and apoptosis of human pulmonary artery smooth muscle cells. Mol Med Rep. 2016 Jul;14(1):715-20. doi: 10.3892/mmr.2016.5333. Epub 2016 May 24. PubMed PMID: 27221642; PubMed Central PMCID: PMC4918544.

[2]Zhou HM, Zhong ML, Wang RH, Long CL, Zhang YF, Cui WY, Wang H. Synergisms of cardiovascular effects between iptakalim and amlodipine, hydrochlorothiazide or propranolol in anesthetized rats. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov;31(6):532-40. PubMed PMID: 27215021.

[3] Wang SY, Cui WY, Wang H. The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels. Acta Pharmacol Sin. 2015 Dec;36(12):1444-50. doi: 10.1038/aps.2015.97. Epub 2015 Nov 23. PubMed PMID: 26592519; PubMed Central PMCID: PMC4816240.

[4] Fan Y, Kong H, Ye X, Ding J, Hu G. ATP-sensitive potassium channels: uncovering novel targets for treating depression. Brain Struct Funct. 2016 Jul;221(6):3111-22. doi: 10.1007/s00429-015-1090-z. Epub 2015 Aug 20. PubMed PMID: 26289962.

[5] Liu W, Kong H, Zeng X, Wang J, Wang Z, Yan X, Wang Y, Xie W, Wang H. Iptakalim inhibits PDGF-BB-induced human airway smooth muscle cells proliferation and migration. Exp Cell Res. 2015 Aug 15;336(2):204-10. doi: 10.1016/j.yexcr.2015.06.020. Epub 2015 Jul 6. PubMed PMID: 26160451.

6: Ji J, Yan H, Chen ZZ, Zhao Z, Yang DD, Sun XL, Shi YP. Iptakalim protects against ischemic injury by improving neurovascular unit function in the mouse brain. Clin Exp Pharmacol Physiol. 2015 Jul;42(7):766-71. doi: 10.1111/1440-1681.12426. PubMed PMID: 25998857.7: Zhu R, Bi LQ, Wu SL, Li L, Kong H, Xie WP, Wang H, Meng ZL. Iptakalim attenuates hypoxia-induced pulmonary arterial hypertension in rats by endothelial function protection. Mol Med Rep. 2015 Aug;12(2):2945-52. doi: 10.3892/mmr.2015.3695. Epub 2015 Apr 28. PubMed PMID: 25936382.8: Huang JH, Han WZ, Jin X, Liu W, Wang H. [The selective dilatation effects of iptakalim on basilar and pulmonary arterioles in high-altitude hypoxic rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2014 Jan;30(1):1-3. Chinese. PubMed PMID: 24741962.9: Lu M, Yang JZ, Geng F, Ding JH, Hu G. Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. Int J Neuropsychopharmacol. 2014 Sep;17(9):1501-10. doi: 10.1017/S1461145714000285. Epub 2014 Mar 13. PubMed PMID: 24621884.10: Huang JH, Han WZ, Zhang YF, Duan RF, Deng HH, Guo YH, Liu W, Wang H. [The selective dilatation effects of iptakalim on pulmonary arterioles in hypoxic pulmonary hypertensive rat]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Jul;29(4):333-6. Chinese. PubMed PMID: 24175556.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开