83843-39-4|GYKI-23107 HCl|N1-(2,6-dimethylphenyl)-N2,N2-dimethylpropane-1,2-diamine dihydrochloride|-范德生物科技公司

GYKI-23107 HCl

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names：
N1-(2,6-dimethylphenyl)-N2,N2-dimethylpropane-1,2-diamine dihydrochloride
CAS号：
83843-39-4
MDL Number：
MF(分子式)： C13H24Cl2N2 MW(分子量)： 279.25
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	GYKI-23107 HCl
英文别名	GYKI-23107; GYKI 23107; GYKI23107; GYKI-23,107; GYKI 23,107; GYKI23,107; GYKI-23107 HCl.
CAS号	83843-39-4
Inchi	InChI=1S/C13H22N2.2ClH/c1-10-7-6-8-11(2)13(10)14-9-12(3)15(4)5;;/h6-8,12,14H,9H2,1-5H3;2*1H
InchiKey	OILXHOMZZDEACA-UHFFFAOYSA-N
分子式 Formula	C13H24Cl2N2
分子量 Molecular Weight	279.25
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	GYKI-23107 HCl(CAS:83843-39-4 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Varró A, Németh M, Rabloczky G, Papp JG, Szekeres L. Electrophysiologicaleffects of GYKI-23 107, a new antiarrhythmic compound, in isolated rabbit andcanine cardiac preparations. J Cardiovasc Pharmacol. 1988 Mar;11(3):251-7. PubMedPMID: 2452917.

[2]Szatmary LJ, Rabloczky G, Kurthy M, Frater E, Solti F. Antifibrillatory effectof GYKI-23107 in induced ventricular vulnerability by local cooling andprogrammed stimulation in canine models. Acta Med Hung. 1988;45(2):221-9. PubMedPMID: 3247245.

[3] Szatmary LJ, Rabloczky G, Kurthy M, Varro A, Solti F. Electrophysiologicaleffects of the antiarrhythmic agent GYKI-23107 in dogs. Acta Med Hung.1988;45(2):209-19. PubMed PMID: 3247244.

[4] Varró A, Rabloczky G, Jaszlits L, Kürthy M, Zubovics Z, Toldy L.Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107. DrugsExp Clin Res. 1987;13(1):21-8. PubMed PMID: 3595441.

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