156223-05-1|GTS-21 dihydrochloride|GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist|-范德生物科技公司

GTS-21 dihydrochloride

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names：
GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist
CAS号：
156223-05-1
MDL Number：
MF(分子式)： C19H22Cl2N2O2 MW(分子量)： 381.3
EINECS: Reaxys Number:
Pubchem ID:5310985 Brand:BIOFOUNT

GTS-21 dihydrochloride(156223-05-1)是一种α7nACh受体的部分激动剂，选择性地与 α7 亚基结合，在 α2、α3 和 α4 没有明显的活性（EC50 = 10 μM 体外（纹状体切片））。GTS-21 dihydrochloride显示出引发促智、神经保护和抗炎的作用。

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中文别名	GTS-21 dihydrochloride(156223-05-1);GTS-21 HCl;GTS-21二盐酸盐;α7烟碱型乙酰胆碱受体激动剂
英文别名	GTS-21 HCl; GTS-21 hydrochloride; GTS-21; GTS 21; GTS21; DMBX-A;DMBX-anabaseine
CAS号	156223-05-1
SMILES	COC1=CC=C(/C=C2C(C3=CC=CN=C3)=NCCC/2)C(OC)=C1.[H]Cl.[H]Cl
Inchi	InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
InchiKey	BXKYFUGAAFLYJL-BXGYHSFXSA-N
分子式 Formula	C19H22Cl2N2O2
分子量 Molecular Weight	381.3
闪点 FP	No data available
熔点 Melting point	no data available
沸点 Boiling point	no data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	淡黄色至黄色固体粉末
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	GTS-21 dihydrochloride(156223-05-1)是一种α7nACh受体的部分激动剂，选择性地与 α7 亚基结合，在 α2、α3 和 α4 没有明显的活性（EC50 = 10 μM 体外（纹状体切片））。
Introduction	GTS-21, also known as DMBX-A, is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
安全声明	H315 H319 H335
安全防护	P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313
备注

[1]Yue Y, Liu R, Cheng W, Hu Y, Li J, Pan X, Peng J, Zhang P. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Oct 17. pii: S1567-5769(15)30138-7. doi: 10.1016/j.intimp.2015.10.005. [Epub ahead of print] PubMed PMID: 26490221.

[2]Kong FJ, Ma LL, Zhang HH, Zhou JQ. Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats. J Surg Res. 2015 Mar;194(1):255-61. doi: 10.1016/j.jss.2014.09.043. Epub 2014 Oct 5. PubMed PMID: 25450597.

[3] Wu S, Zhao H, Luo H, Xiao X, Zhang H, Li T, Zuo X. GTS-21, an α7-nicotinic acetylcholine receptor agonist, modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis. Exp Ther Med. 2014 Aug;8(2):557-562. Epub 2014 Jun 3. PubMed PMID: 25009619; PubMed Central PMCID: PMC4079428.

[4] Hu Y, Liu R, Li J, Yue Y, Cheng W, Zhang P. Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21. Biomed Res Int. 2014;201

[5]325875. doi: 10.1155/2014/325875. Epub 2014 Feb 27. PubMed PMID: 24719855; PubMed Central PMCID: PMC3955649.

5: Sitapara RA, Antoine DJ, Sharma L, Patel VS, Ashby CR Jr, Gorasiya S, Yang H, Zur M, Mantell LL. The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function. Mol Med. 2014 Jun 19;20:238-47. doi: 10.2119/molmed.2013.00086. PubMed PMID: 24664237; PubMed Central PMCID: PMC4069272.

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