145177-42-0|GHRP-6 acetate|L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate|-范德生物科技公司

GHRP-6 acetate

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names：
L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate
CAS号：
145177-42-0
MDL Number：
MF(分子式)： C52H68N12O12 MW(分子量)： 1053.19
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	GHRP-6 acetate
英文别名	GHRP-6 acetate, Growth hormone releasing peptide 6 acetate, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E
CAS号	145177-42-0
SMILES	O=C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N)=O)CCCCN)=O)[C@@H](NC([C@H](C)NC([C@H](NC([C@H](CC2=CN=CN2)N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O.CC(O)=O.CC(O)=O
Inchi	InChI=1S/C46H56N12O6.3C2H4O2/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47;31-2(3)4/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64);31H3,(H,3,4)/t27-,34-,37-,38+,39+,40-;;;/m0.../s1
InchiKey	XGWOPQAMQAZCJE-SLBOMMQWSA-N
分子式 Formula	C52H68N12O12
分子量 Molecular Weight	1053.19
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	A crystalline solid
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	GHRP-6 acetate(CAS:145177-42-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	GHRP-6 acetate is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (Ibutamoren) to COS-7 cell membranes expressing human GHS-R type Ia and binding of ghrelin to COS-7 cells expressing human GHS-R. GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor and inositol phosphate production in COS-7 cells expressing the human receptor. It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland. It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bowers, C.Y., Momany, F.A., Reynolds, G.A., et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114(5), 1537-1545 (1984).2.