221018-88-8|Crobenetine hydrochloride|(2R,6S)-3-((S)-2-(benzyloxy)propyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro 2,6-methanobenzo[d]azocin-10-ol hydrochloride|-范德生物科技公司

Crobenetine hydrochloride

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names：
(2R,6S)-3-((S)-2-(benzyloxy)propyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro 2,6-methanobenzo[d]azocin-10-ol hydrochloride
CAS号：
221018-88-8
MDL Number：
MF(分子式)： C25H34ClNO2 MW(分子量)： 416.002
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Crobenetine hydrochloride
英文别名	BIII-890; BIII-890-CL; BIII-890 CL
CAS号	221018-88-8
Inchi	InChI=1S/C25H33NO2.ClH/c1-18(28-17-19-9-6-5-7-10-19)16-26-14-13-25(4)21-11-8-12-22(27)20(21)15-23(26)24(25,2)3;/h5-12,18,23,27H,13-17H2,1-4H3;1H/t18-,23+,25-;/m0./s1
InchiKey	UWKTVIXWZRROOI-VLIWAZBPSA-N
分子式 Formula	C25H34ClNO2
分子量 Molecular Weight	416.002
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Crobenetine hydrochloride(CAS:221018-88-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Crobenetine hydrochloride is a sodium channel antagonist potentially for the treatment of stroke.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Carter AJ, Grauert M, Pschorn U, Bechtel WD, Bartmann-Lindholm C, Qu Y, Scheuer T, Catterall WA, Weiser T. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9. PubMed PMID: 10781102; PubMed Central PMCID: PMC18337.

[2]Grauert M, Bechtel WD, Weiser T, Stransky W, Nar H, Carter AJ. Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. J Med Chem. 2002 Aug 15;45(17):3755-64. PubMed PMID: 12166948.

1: Meythaler J. BIII-890-CL. Boehringer Ingelheim. Curr Opin Investig Drugs. 2002 Dec;3(12):1733-5. Review. PubMed PMID: 12528308.

[4]Carter AJ, Grauert M, Pschorn U, Bechtel WD, Bartmann-Lindholm C, Qu Y, Scheuer T, Catterall WA, Weiser T. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9. PubMed PMID: 10781102; PubMed Central PMCID: PMC18337.

[5] Dekker LV, Daniels Z, Hick C, Elsegood K, Bowden S, Szestak T, Burley JR, Southan A, Cronk D, James IF. Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells. Eur J Pharmacol. 2005 Dec 28;528(1-3):52-8. PubMed PMID: 16325806.

5: Laird JM, Carter AJ, Grauert M, Cervero F. Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats. Br J Pharmacol. 2001 Dec;134(8):1742-8. PubMed PMID: 11739251; PubMed Central PMCID: PMC1572907.

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