134457-26-4|Azaline|Azaline|-范德生物科技公司

Azaline

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names：
Azaline
CAS号：
134457-26-4
MDL Number：
MF(分子式)： C74H106ClN23O12 MW(分子量)： 1545.26
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(S)-N-((2R,4S,7R)-7-acetamido-2-amino-4-((N6-(5-amino-1H-1,2,4-triazol-3-yl)-D-lysyl-L-leucyl)(N6-(5-amino-1H-1,2,4-triazol-3-yl)-L-lysyl)carbamoyl)-1-(4-chlorophenyl)-8-(naphthalen-2-yl)-3,6-dioxooctan-4-yl)-N-(((R)-2-amino-3-(pyridin-3-yl)propanoyl)-L-seryl)-1-(N6-isopropyl-L-lysyl)pyrrolidine-2-carboxamide
英文别名	Azaline; Azaline A;
CAS号	134457-26-4
SMILES	CC(C[C@H](NC([C@H](N)CCCCNc1n[nH]c(N)n1)=O)C(N(C([C@](C([C@H](N)Cc2ccc(Cl)cc2)=O)(N(C([C@@H](NC([C@H](N)Cc3cnccc3)=O)CO)=O)C([C@@H]4CCCN4C([C@@H](N)CCCCNC(C)C)=O)=O)CC([C@H](NC(C)=O)Cc(cc5)cc6c5cccc6)=O)=O)C([C@@H](N)CCCCNc7n[nH]c(N)n7)=O)=O)C
Inchi	1S/C74H106ClN23O12/c1-42(2)34-57(88-62(103)51(76)19-8-12-31-85-72-90-70(81)92-94-72)66(107)97(65(106)53(78)21-10-13-32-86-73-91-71(82)93-95-73)69(110)74(61(102)54(79)36-45-24-27-50(75)28-25-45,39-60(101)56(87-44(5)100)38-46-23-26-48-17-6-7-18-49(48)35-46)98(67(108)58(41-99)89-63(104)55(80)37-47-16-14-29-83-40-47)68(109)59-22-15-33-96(59)64(105)52(77)20-9-11-30-84-43(3)4/h6-7,14,16-18,23-29,35,40,42-43,51-59,84,99H,8-13,15,19-22,30-34,36-39,41,76-80H2,1-5H3,(H,87,100)(H,88,103)(H,89,104)(H4,81,85,90,92,94)(H4,82,86,91,93,95)/t51-,52+,53+,54-,55-,56-,57+,58+,59+,74+/m1/s1
InchiKey	XHCGTVHIQUXPRM-SSIREWOPSA-N
分子式 Formula	C74H106ClN23O12
分子量 Molecular Weight	1545.26
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Azaline(CAS:134457-26-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Azaline is a gonadorelin antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ballantyne K, Anderson ST, Pyne M, Nicolson V, Mucci A, Lisle A, Johnston SD. Use of the gonadotrophin-releasing hormone antagonist azaline B to control the oestrous cycle in the koala (Phascolarctos cinereus). Reprod Fertil Dev. 2015 May [1]doi: 10.1071/RD14349. [Epub ahead of print] PubMed PMID: 25929179.

[2]Chakraborty P, Roy SK. Effect of azaline B on follicular development and functions in the hamster. Mol Cell Endocrinol. 2015 Jan 15;400:1-9. doi: 10.1016/j.mce.2014.11.011. Epub 2014 Nov 24. PubMed PMID: 25462584; PubMed Central PMCID: PMC4274241.

[3] Campen CA, Lai MT, Kraft P, Kirchner T, Phillips A, Hahn DW, Rivier J. Potent pituitary-gonadal axis suppression and extremely low anaphylactoid activity of a new gonadotropin releasing hormone (GnRH) receptor antagonist "azaline B". Biochem Pharmacol. 1995 May 11;49(9):1313-21. PubMed PMID: 7763313.

[4] Rivier JE, Jiang G, Porter J, Hoeger CA, Craig AG, Corrigan A, Vale W, Rivier CL. Gonadotropin-releasing hormone antagonists: novel members of the azaline B family. J Med Chem. 1995 Jul 7;38(14):2649-62. PubMed PMID: 7629804.

[5] Samant MP, Gulyas J, Hong DJ, Croston G, Rivier C, Rivier J. Synthesis, in vivo and in vitro biological activity of novel azaline B analogs. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2894-7. PubMed PMID: 15911275.

6: Rivier J, Porter J, Hoeger C, Theobald P, Craig AG, Dykert J, Corrigan A, Perrin M, Hook WA, Siraganian RP, et al. Gonadotropin-releasing hormone antagonists with N omega-triazolylornithine, -lysine, or -p-aminophenylalanine residues at positions 5 and 6. J Med Chem. 1992 Nov 13;35(23):4270-8. PubMed PMID: 1280300.7: Samant MP, Hong DJ, Croston G, Rivier C, Rivier J. Novel gonadotropin-releasing hormone antagonists with substitutions at position 5. Biopolymers. 2005;80(2-3):386-91. PubMed PMID: 15614806.8: Rivier J, Theobald P, Porter J, Perrin M, Gunnet J, Hahn DW, Rivier C. Gonadotropin releasing hormone antagonists: novel structures incorporating N omega-cyano modified guanidine moieties. Biochem Biophys Res Commun. 1991 Apr 15;176(1):406-12. PubMed PMID: 1850267.9: Jiang G, Stalewski J, Galyean R, Dykert J, Schteingart C, Broqua P, Aebi A, Aubert ML, Semple G, Robson P, Akinsanya K, Haigh R, Riviere P, Trojnar J, Junien JL, Rivier JE. GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6. J Med Chem. 2001 Feb 1;44(3):453-67. PubMed PMID: 11462984.10: Zhu LJ, Hardy MP, Inigo IV, Huhtaniemi I, Bardin CW, Moo-Young AJ. Effects of androgen on androgen receptor expression in rat testicular and epididymal cells: a quantitative immunohistochemical study. Biol Reprod. 2000 Aug;63(2):368-76. PubMed PMID: 10906039.1

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