151232-75-6|Allotrap|Allotrap|-范德生物科技公司

Allotrap

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names：
Allotrap
CAS号：
151232-75-6
MDL Number：
MF(分子式)： C53H90N20O16 MW(分子量)： 1263.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK11099-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	(2S,8S,11S,14S,17S,20S,23S,26S)-14-(2-amino-2-oxoethyl)-26-((S)-2-amino-5-guanidinopentanamido)-8,17-bis(3-guanidinopropyl)-2-(4-hydroxybenzyl)-23-(hydroxymethyl)-11,20-diisobutyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazanonacosanedioic acid
英文别名	Allotrap; Peptide Bc-1nl;
CAS号	151232-75-6
Inchi	InChI=1S/C53H90N20O16/c1-26(2)20-34(46(84)68-31(9-6-18-63-52(58)59)43(81)65-24-40(77)66-37(50(88)89)22-28-11-13-29(75)14-12-28)70-48(86)36(23-39(55)76)72-44(82)32(10-7-19-64-53(60)61)69-47(85)35(21-27(3)4)71-49(87)38(25-74)73-45(83)33(15-16-41(78)79)67-42(80)30(54)8-5-17-62-51(56)57/h11-14,26-27,30-38,74-75H,5-10,15-25,54H2,1-4H3,(H2,55,76)(H,65,81)(H,66,77)(H,67,80)(H,68,84)(H,69,85)(H,70,86)(H,71,87)(H,72,82)(H,73,83)(H,78,79)(H,88,89)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64)/t30-,31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
InchiKey	KXASYRUYKYOKGG-IWLMWFOOSA-N
分子式 Formula	C53H90N20O16
分子量 Molecular Weight	1263.42
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Allotrap(CAS:151232-75-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Allotrap is a small synthetic peptide derived from the alpha1 helix of the heavy chain of HLA class I proteins; inhibits human T cell responses in vitro; prolongs allograft survival in rats and mice.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tice DG, Bruch D, Buelow R, Squiers EC. Survival of rat small bowel allografts treated with allotrap 07R. J Surg Res. 1997 Sep;72(1):78-83. PubMed PMID: 9344717.

[2]Iyer S, Kontoyiannis D, Chevrier D, Woo J, Mori N, Cornejo M, Kollias G, Buelow R. Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide. J Biol Chem. 2000 Jun 2;275(22):17051-7. PubMed PMID: 10748117.

[3] Buelow R, Veyron P, Clayberger C, Pouletty P, Touraine JL. Prolongation of skin allograft survival in mice following administration of ALLOTRAP. Transplantation. 1995 Feb 27;59(4):455-60. PubMed PMID: 7878745.

[4] Oberyszyn TM, Robertson FM, Tober KL, Ross MS, Parrett ML, Wilgus TA, Iyer S, Woo J, Buelow R. Inhibition of cutaneous UV light-induced tumor necrosis factor-alpha protein production by Allotrap 1258, a novel immunomodulatory peptide. Photochem Photobiol. 2001 Feb;73(2):184-90. PubMed PMID: 11272733.

[5] Gao L, Woo J, Buelow R. Both L- and D-isomers of allotrap 2702 prolong cardiac allograft survival in mice. J Heart Lung Transplant. 1996 Jan;15(1 Pt 1):78-87. PubMed PMID: 8820086.

6: Li W, Iyer S, Lu L, Buelow R, Fung JJ, Rao AS, Woo J, Qian S. Attenuation of aortic graft arteriosclerosis by systemic administration of Allotrap peptide RDP58. Transpl Int. 2003 Dec;16(12):849-56. Epub 2003 Aug 27. PubMed PMID: 12942166.7: Squiers EC, Hodell M, Beulow R. Allotrap prolongs survival of porcine islet xenografts in diabetic mice. Transplant Proc. 1997 Jun;29(4):2168-9. PubMed PMID: 9193574.8: Masroor S, Itescu S, Artrip JH, Minanov OP, Buelow R, Michler RE. Induction of tolerance in rodent cardiac allotransplantation using an MHC class I-derived peptide and cyclosporin A. Ann Thorac Surg. 1998 Jan;65(1):144-8. PubMed PMID: 9456108.9: Yu X, Song B, Huang C, Xiao Y, Fang M, Feng J, Wang P, Zhang G. Prolonged survival time of allografts by the oral administration of RDP58 linked to the cholera toxin B subunit. Transpl Immunol. 2012 Oct;27(2-3):122-7. doi: 10.1016/j.trim.2012.06.004. Epub 2012 Jun 15. PubMed PMID: 22709942.10: Tice DG, Bruch D, Squiers EC. Graft survival and MLC response in LEW-ACI small bowel transplants treated with a novel MHC peptide, BC-1nl. Transplant Proc. 1998 Sep;30(6):2590-1. PubMed PMID: 9745504.1

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