114417-20-8|Alilusem|7-Chloro-1-(2-methylbenzoyl)-2,3-dihydroquinolin-4(1H)-one (E)-O-sulfooxime|-范德生物科技公司

Alilusem

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names：
7-Chloro-1-(2-methylbenzoyl)-2,3-dihydroquinolin-4(1H)-one (E)-O-sulfooxime
CAS号：
114417-20-8
MDL Number：
MF(分子式)： C17H15ClN2O5S MW(分子量)： 394.83
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Alilusem
英文别名	Alilusem; Alilusem potassium; M 17055; D09772; M17055;
CAS号	114417-20-8
Inchi	InChI=1S/C17H15ClN2O5S/c1-11-4-2-3-5-13(11)17(21)20-9-8-15(19-25-26(22,23)24)14-7-6-12(18)10-16(14)20/h2-7,10H,8-9H2,1H3,(H,22,23,24)/b19-15+
InchiKey	QQCSUWGQBREWRO-XDJHFCHBSA-N
分子式 Formula	C17H15ClN2O5S
分子量 Molecular Weight	394.83
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Alilusem(CAS:114417-20-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Alilusem is a novel diuretic, it possesses beneficial properties for the clinical treatment of hypertension. Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells, OATP-B plays a major role in the uptake of the novel loop diuretic M17055 from apical membranes in Caco-2 cells.
Application1
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Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B. Pharm Res. 2007 Jan;24(1):90-8. Epub 2006 Nov 14. PubMed PMID: 17103337.

[2]Nishimura T, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats. J Pharm Sci. 2004 Oct;93(10):2558-66. PubMed PMID: 15349965.

[3] Nakajima H, Nakanishi T, Naba H, Nakai K, Matsumoto S, Nagasawa K, Ida K, Ogihara T, Ohzawa N. Studies on the metabolic fate of M17055, a novel diuretic (6). Assessment for drug-drug interactions of M17055 in metabolism, distribution and excretion. Xenobiotica. 2002 Dec;32(12):1161-72. PubMed PMID: 12593763.

[4] Kim S, Hamaguchi A, Shinkawa T, Kato Y, Tsuchiya N, Miura K, Ohta K, Iwao H. Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats. J Pharmacol Exp Ther. 1996 Nov;279(2):983-90. PubMed PMID: 8930208.

[5] Shinkawa T, Kato Y, Tsuchiya N, Yamasaki F, Uemura A, Mizota M. Beneficial effect of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats. Jpn J Pharmacol. 1993 Oct;63(2):241-9. PubMed PMID: 8283835.

6: Yamasaki F, Yoshitomi K, Shinkawa T, Imai M. Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting tubule. J Pharmacol Exp Ther. 1993 Sep;266(3):1589-93. PubMed PMID: 8396639.7: Yasoshima K, Yamasaki F, Shinkawa T, Yoshitomi K, Imai M. Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments. J Pharmacol Exp Ther. 1993 Sep;266(3):1581-8. PubMed PMID: 8396638.8: Shinkawa T, Yamasaki F, Notsu T, Nakakuki M, Nishijima K, Yoshitomi K, Imai M. Loop and distal actions of a novel diuretic, M17055. Eur J Pharmacol. 1993 Jul 20;238(2-3):317-25. PubMed PMID: 8405100.9: Shinkawa T, Yamasaki F, Kikuchi A, Nakakuki M, Nishijima K, Uemura A, Mizota M, Orita Y. Pharmacological properties of the novel highly potent diuretic 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt. Arzneimittelforschung. 1992 Dec;42(12):1466-72. PubMed PMID: 1337698.

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