166591-11-3|Adrogolide HCl|Benzo(f)thieno(2,3-c)quinoline-9,10-diol, 4,5,5a,6,7,11b-hexahydro-2-propyl-, diacetate (ester), hydrochloride, (5aR-trans)-|-范德生物科技公司

Adrogolide HCl

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names：
Benzo(f)thieno(2,3-c)quinoline-9,10-diol, 4,5,5a,6,7,11b-hexahydro-2-propyl-, diacetate (ester), hydrochloride, (5aR-trans)-
CAS号：
166591-11-3
MDL Number：
MF(分子式)： C22H26ClNO4S MW(分子量)： 435.96
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Adrogolide HCl
英文别名	Adrogolide Hydrochloride; Adrogolide HCl; A-93431.1; A93431.1; A 93431.1; DAS 431; DAS-431; DAS431; ABT 431;ABT-431;ABT431;
CAS号	166591-11-3
SMILES	CCCC(S1)=CC2=C1CN[C@]3([H])CCC4=CC(OC(C)=O)=C(OC(C)=O)C=C4[C@@]23[H].[H]Cl
Inchi	InChI=1S/C22H25NO4S.ClH/c1-4-5-15-9-17-21(28-15)11-23-18-7-6-14-8-19(26-12(2)24)20(27-13(3)25)10-16(14)22(17)18;/h8-10,18,22-23H,4-7,11H2,1-3H3;1H/t18-,22+;/m1./s1
InchiKey	NPEZSCRKHFTLPE-MYXGOWFTSA-N
分子式 Formula	C22H26ClNO4S
分子量 Molecular Weight	435.96
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Adrogolide HCl(CAS:166591-11-3 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Adrogolide Hydrochloride acts as a selective dopamine receptor D1 agonist. It was developed as a possible treatment for Parkinson's disease, as well as for other applications such as treatment of cocaine addiction. It has mainly been used as its diacetate ester prodrug adrogolide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Gleason SD, Witkin JM. Effects of dopamine D1 receptor full agonists in rats trained to discriminate SKF 38393. Behav Pharmacol. 2004 Feb;15(1):85-9. PubMed PMID: 15075630.

[2]Castner SA, Goldman-Rakic PS. Enhancement of working memory in aged monkeys by a sensitizing regimen of dopamine D1 receptor stimulation. J Neurosci. 2004 Feb 11;24(6):1446-50. PubMed PMID: 14960617.

[3] Okumu FW, Lee RY, Blanchard JD, Queirolo A, Woods CM, Lloyd PM, Okikawa J, Gonda I, Farr SJ, Rubsamen R, Adjei AL, Bertz RJ. Evaluation of the AERx pulmonary delivery system for systemic delivery of a poorly soluble selective D-1 agonist, ABT-431. Pharm Res. 2002 Jul;19(7):1009-12. PubMed PMID: 12180532.

[4] Giardina WJ, Williams M. Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7(3):305-16. Review. PubMed PMID: 11607045.

[5] Rascol O, Nutt JG, Blin O, Goetz CG, Trugman JM, Soubrouillard C, Carter JH, Currie LJ, Fabre N, Thalamas C, Giardina WW, Wright S. Induction by dopamine D1 receptor agonist ABT-431 of dyskinesia similar to levodopa in patients with Parkinson disease. Arch Neurol. 2001 Feb;58(2):249-54. PubMed PMID: 11176963.

6: Self DW, Karanian DA, Spencer JJ. Effects of the novel D1 dopamine receptor agonist ABT-431 on cocaine self-administration and reinstatement. Ann N Y Acad Sci. 2000;909:133-44. PubMed PMID: 10911927.7: Castner SA, Williams GV, Goldman-Rakic PS. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation. Science. 2000 Mar 17;287(5460):2020-2. PubMed PMID: 10720329.8: Zheng Y, Marsh KC, Bertz RJ, El-Shourbagy T, Adjei AL. Pulmonary delivery of a dopamine D-1 agonist, ABT-431, in dogs and humans. Int J Pharm. 1999 Nov 30;191(2):131-40. PubMed PMID: 10564839.9: Rascol O, Blin O, Thalamas C, Descombes S, Soubrouillard C, Azulay P, Fabre N, Viallet F, Lafnitzegger K, Wright S, Carter JH, Nutt JG. ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease. Ann Neurol. 1999 Jun;45(6):736-41. PubMed PMID: 10360765.10: Haney M, Collins ED, Ward AS, Foltin RW, Fischman MW. Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humans. Psychopharmacology (Berl). 1999 Mar;143(1):102-10. PubMed PMID: 10227086.1

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