116364-81-9|A 83586C|A 83586C|-范德生物科技公司

A 83586C

NMR下载 COA and HPLC MSDS下载
names：
A 83586C
CAS号：
116364-81-9
MDL Number：
MF(分子式)： C47H76N8O14 MW(分子量)： 977.17
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	(S)-2-((2R,5S,6S)-6-((S,2E,6E)-4,6-dimethyl-5-oxoocta-2,6-dien-2-yl)-2-hydroxy-5-methyltetrahydro-2H-pyran-2-yl)-2-hydroxy-N-((4aR,7S,10R,16aS,19R,22S,23S)-6-hydroxy-19-((S)-1-hydroxyethyl)-22-isopropyl-7,9,10-trimethyl-5,8,11,17,20,24-hexaoxodocosahydro-13H,22H-dipyridazino[6,1-f6',1'-o][1]oxa[4,7,10,13,16]pentaazacyclononadecin-23-yl)butanamide
英文别名	A 83586C; A-83586C; A83586C
CAS号	116364-81-9
SMILES	CC[C@@]([C@@]1(O)CC[C@H](C)[C@@H](/C(C)=C/[C@@H](C(/C(C)=C/C)=O)C)O1)(O)C(N[C@H]2[C@H](C(C)C)OC([C@@H]([C@@H](O)C)NC([C@@H]3CCCNN3C([C@@H](C)N(C)C([C@H](C)N(O)C([C@H]4CCCNN4C2=O)=O)=O)=O)=O)=O)=O
Inchi	InChI=1S/C47H76N8O14/c1-13-25(5)36(57)27(7)23-28(8)38-26(6)19-20-47(66,69-38)46(65,14-2)45(64)51-35-37(24(3)4)68-44(63)34(31(11)56)50-39(58)32-17-15-21-48-53(32)41(60)29(9)52(12)40(59)30(10)55(67)42(61)33-18-16-22-49-54(33)43(35)62/h13,23-24,26-27,29-35,37-38,48-49,56,65-67H,14-22H2,1-12H3,(H,50,58)(H,51,64)/b25-13+,28-23+/t26-,27-,29+,30-,31-,32-,33+,34+,35-,37-,38-,46+,47+/m0/s1
InchiKey	BJRNAAQGIMGUML-IYSUCPQHSA-N
分子式 Formula	C47H76N8O14
分子量 Molecular Weight	977.17
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	A 83586C(CAS:116364-81-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	A 83586C is a depsipeptide antibiotic from Streptomyces karnatakensis that shows potent Gram-positive activity in vitro. It functions as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating osteopontin (Opn) expression. A83586C antitumor cyclodepsipeptides also inhibit E2F-mediated transcription by downregulating E2F1 expression and inducing dephosphorylation of the oncogenic hyperphosphorylated retinoblastoma protein (pRb).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Smitka TA, Deeter JB, Hunt AH, Mertz FP, Ellis RM, Boeck LD, Yao RC. A83586C, a new depsipeptide antibiotic. J Antibiot (Tokyo). 1988 Jun;41(6):726-33. PubMed PMID: 3403366.

[2]Assem ES, Peh KH, Wan BY, Manaviazar S, Walters MA, George JH, Hale KJ. Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins. Inflamm Res. 2008;57 Suppl 1:S21-2. doi: 10.1007/s00011-007-0610-6. PubMed PMID: 18345507.

[3] Hale KJ, Manaviazar S, George JH, Walters MA, Dalby SM. Total synthesis of (+)-azinothricin and (+)-kettapeptin. Org Lett. 2009 Feb 5;11(3):733-6. doi: 10.1021/ol802817t. PubMed PMID: 19175351.

[4] Hale KJ, Manaviazar S, George J. Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription. Chem Commun (Camb). 2010 Jun 21;46(23):4021-42. doi: 10.1039/c000603c. Epub 2010 Apr 19. PubMed PMID: 20405066.

[5] Hale KJ, Lazarides L. Synthesis of an L-proline modified mimetic of the A83586C antitumour cyclodepsipeptide. Chem Commun (Camb). 2002 Sep 7;(17):1832-3. PubMed PMID: 12271631.

6: Hale KJ, Lazarides L. Synthetic route to the GE3 cyclodepsipeptide. Org Lett. 2002 May 30;4(11):1903-6. PubMed PMID: 12027643.7: Hale KJ, Manaviazar S, Lazarides L, George J, Walters MA, Cai J, Delisser VM, Bhatia GS, Peak SA, Dalby SM, Lefranc A, Chen YN, Wood AW, Crowe P, Erwin P, El-Tanani M. Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb. Org Lett. 2009 Feb 5;11(3):737-40. doi: 10.1021/ol802818f. PubMed PMID: 19175352.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开