13209-52-5|A 68828|A 68828|-范德生物科技公司

A 68828

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names：
A 68828
CAS号：
13209-52-5
MDL Number：
MF(分子式)： C68H116N26O15S2 MW(分子量)： 1601.963
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(6S,9R,13R,16S,19S,22S,25S,28S)-1,6-diamino-28-((2S,5S,14S,Z)-14-amino-2-((S)-sec-butyl)-15-cyclohexyl-5-(3-guanidinopropyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadec-11-enamido)-19-benzyl-22-((S)-sec-butyl)-16,25-bis(3-guanidinopropyl)-1-imino-9,13-bis(mercaptomethyl)-7,10,12,15,18,21,24,27-octaoxo-2,8,11,14,17,20,23,26-octaazatriacontan-30-oic acid
英文别名	A 68828; A-68828; A68828
CAS号	13209-52-5
SMILES	CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(/C=N\C([C@@H](N)CC1CCCCC1)=O)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC(O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CS)=O)=O)CS)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O)C
Inchi	InChI=1S/C68H116N26O15S2/c1-5-36(3)52(63(108)88-45(30-39-19-11-8-12-20-39)59(104)86-43(23-15-27-81-67(75)76)56(101)91-48(35-111)62(107)94-61(106)47(34-110)90-55(100)40(69)21-13-25-79-65(71)72)93-58(103)44(24-16-28-82-68(77)78)87-60(105)46(31-51(97)98)89-64(109)53(37(4)6-2)92-57(102)42(22-14-26-80-66(73)74)85-50(96)33-83-49(95)32-84-54(99)41(70)29-38-17-9-7-10-18-38/h8,11-12,19-20,32,36-38,40-48,52-53,110-111H,5-7,9-10,13-18,21-31,33-35,69-70H2,1-4H3,(H,83,95)(H,85,96)(H,86,104)(H,87,105)(H,88,108)(H,89,109)(H,90,100)(H,91,101)(H,92,102)(H,93,103)(H,97,98)(H4,71,72,79)(H4,73,74,80)(H4,75,76,81)(H4,77,78,82)(H,94,106,107)/b84-32-/t36-,37-,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-,53-/m0/s1
InchiKey	HCJNLCHEKMAIHX-PVCRQNKGSA-N
分子式 Formula	C68H116N26O15S2
分子量 Molecular Weight	1601.963
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	A 68828(CAS:13209-52-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	A 68828 is an atrial natriuretic factor analog. It improves renal function and reduces tissue damage.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Pollock DM, Opgenorth TJ. Beneficial effect of the atrial natriuretic factor analog A68828 in postischemic acute renal failure. J Pharmacol Exp Ther. 1990 Dec;255(3):1166-9. PubMed PMID: 2148187.

[2]Pollock DM, Opgenorth TJ. Beneficial effect of the ANF analog A68828 on recovery from ischemic acute renal failure. Ren Fail. 1992;14(2):141-6. PubMed PMID: 1386156.

[3] Deegan PM, Ryan MP, Basinger MA, Jones MM, Hande KR. Protection from cisplatin nephrotoxicity by A68828, an atrial natriuretic peptide. Ren Fail. 1995 Mar;17(2):117-23. PubMed PMID: 7644762.

[4] Pollock DM, Holst M, Opgenorth TJ. Effect of the ANF analog A68828 in cisplatin-induced acute renal failure. J Pharmacol Exp Ther. 1991 Jun;257(3):1179-83. PubMed PMID: 1828504.

[5] Devine EM Jr, Buko AM, Cepa SP, Davidsen SK, Holleman WH, Marselle CA, Opgenorth TJ, Rockway TW, von Geldern TW. HPLC and PDMS analysis of cleavage products aid in the design of small, stable ANP analogues. Int J Pept Protein Res. 1992 Dec;40(6):532-7. PubMed PMID: 1286937.

6: von Geldern TW, Rockway TW, Davidsen SK, Budzik GP, Bush EN, Chu-Moyer MY, Devine EM Jr, Holleman WH, Johnson MC, Lucas SD, et al. Small atrial natriuretic peptide analogues: design, synthesis, and structural requirements for guanylate cyclase activation. J Med Chem. 1992 Mar 6;35(5):808-16. PubMed PMID: 1347790.7: Pollock DM, Opgenorth TJ. Atrial natriuretic peptides in the treatment of acute renal failure. Ren Fail. 1993;15(4):439-49. Review. PubMed PMID: 8210557.8: Holleman WH, Budzik GP, Devine EM, Pollock DM, Opgenorth TJ, Thomas AM, von Geldern TW, Rockway TW. Truncated atrial natriuretic factor analogs retain full agonist activity. Can J Physiol Pharmacol. 1991 Oct;69(10):1622-7. PubMed PMID: 1663820.

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