145781-32-4|Zolasartan|1-((3-Bromo-2-(o-1H-tetrazol-5-ylphenyl)-5-benzofuranyl)methyl)-2-butyl-4-chloroimidazole-5-carboxylic acid|-范德生物科技公司

Zolasartan

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names：
1-((3-Bromo-2-(o-1H-tetrazol-5-ylphenyl)-5-benzofuranyl)methyl)-2-butyl-4-chloroimidazole-5-carboxylic acid
CAS号：
145781-32-4
MDL Number：
MF(分子式)： C24H20BrClN6O3 MW(分子量)： 555.817
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1-((3-Bromo-2-(o-1H-tetrazol-5-ylphenyl)-5-benzofuranyl)methyl)-2-butyl-4-chloroimidazole-5-carboxylic acid
英文别名	Zolasartan; GR-117289; GR117289; GR 117289; GR 117289C; GR-117289C; GR117289C.
CAS号	145781-32-4
SMILES	O=C(C1=C(Cl)N=C(CCCC)N1CC2=CC=C(OC(C3=CC=CC=C3C4=NN=NN4)=C5Br)C5=C2)O
Inchi	InChI=1S/C24H20BrClN6O3/c1-2-3-8-18-27-22(26)20(24(33)34)32(18)12-13-9-10-17-16(11-13)19(25)21(35-17)14-6-4-5-7-15(14)23-28-30-31-29-23/h4-7,9-11H,2-3,8,12H2,1H3,(H,33,34)(H,28,29,30,31)
InchiKey	FIKYECRHLXONOX-UHFFFAOYSA-N
分子式 Formula	C24H20BrClN6O3
分子量 Molecular Weight	555.817
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	White to off-white crystalline powder.
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Zolasartan(CAS:145781-32-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Zolasartan, also known as GR-117289 or GR 117289C, is a potent, specific, selective and insurmountable antagonist at angiotensin AT, receptors. Its profile in the rabbit aorta is consistent with the proposalthat GRI17289 is a slowly reversible (pseudo-irreversible) antagonist at these receptors.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Shuttleworth G, Hunter MG, Broughton Pipkin F. Autoradiographic determination of angiotensin II receptors in prepubertal and postpubertal pig ovarian tissue. Reproduction. 2001 Nov;122(5):701-10. PubMed PMID: 11690530.

[2]Liu MH, Floten HS, Furnary AP, Yim AP, He GW. Inhibition of vasoconstriction by angiotensin receptor antagonist GR117289C in arterial grafts. Ann Thorac Surg. 2000 Dec;70(6):2064-9. PubMed PMID: 11156121.

[3] Tebbs C, Pratten MK, Broughton Pipkin F. Angiotensin II is a growth factor in the peri-implantation rat embryo. J Anat. 1999 Jul;195 ( Pt 1):75-86. PubMed PMID: 10473295; PubMed Central PMCID: PMC1467967.

[4] Lyons D, Webster J, Nixon A, Young MM, Smith J, Benjamin N. Effect of the non peptide angiotensin II antagonist, GR117289C on the vasoconstrictor actions of angiotensin II in the human forearm. Br J Clin Pharmacol. 1997 Mar;43(3):323-6. PubMed PMID: 9088589; PubMed Central PMCID: PMC2042751.

[5] Polidori C, Ciccocioppo R, Pompei P, Cirillo R, Massi M. Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats. Eur J Pharmacol. 1996 Jul 4;307(3):259-67. PubMed PMID: 8836613.

6: Grace AA, Metcalfe JC, Weissberg PL, Bethell HW, Vandenberg JI. Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart. Am J Physiol. 1996 Jun;270(6 Pt 1):C1687-94. PubMed PMID: 8764151.7: Cannell RJ, Knaggs AR, Dawson MJ, Manchee GR, Eddershaw PJ, Waterhouse I, Sutherland DR, Bowers GD, Sidebottom PJ. Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite. Drug Metab Dispos. 1995 Jul;23(7):724-9. PubMed PMID: 7587961.8: Forhead AJ, Fowden AL, Silver M, Hughes P, Broughton-Pipkin F, Sutherland MF. Haemodynamic responses to an angiotensin II receptor antagonist (GR 117289) in maternal and fetal sheep. Exp Physiol. 1995 Mar;80(2):285-98. PubMed PMID: 7786519.9: Murkitt GS, Trafankowska EZ, Dunne M, Manchee GR. Fully automated assay for the determination of GR117289X in human plasma using mixed mode solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Pharm Biomed Anal. 1994 Sep;12(9):1181-7. PubMed PMID: 7803570.10: Bowers GD, Eddershaw PJ, Hughes SY, Manchee GR, Oxford J. Characterization of glucuronic acid conjugates of a novel angiotensin receptor antagonist. Rapid Commun Mass Spectrom. 1994 Feb;8(2):217-21. PubMed PMID: 8155901.1

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