83910-34-3|ZK-91296|ethyl 5-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate|-范德生物科技公司

ZK-91296

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names：
ethyl 5-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate
CAS号：
83910-34-3
MDL Number：
MF(分子式)： C23H22N2O4 MW(分子量)： 390.439
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ethyl 5-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate
英文别名	ZK-91296; ZK 91296; ZK91296.
CAS号	83910-34-3
Inchi
InchiKey
分子式 Formula	C23H22N2O4
分子量 Molecular Weight	390.439
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ZK-91296(CAS:83910-34-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ZK-91296 is a GABA receptor agonist potentially for the treatment of anxiety. ZK 91296 can reduce anxiety in animals at doses well below those causing sedation. ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]De Deyn PP, Macdonald RL. CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture. J Pharmacol Exp Ther. 1987 Jul;242(1):48-55. PubMed PMID: 3039114.

[2]Sanger DJ, Zivkovic B. Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296. Neuropharmacology. 1987 May;26(5):499-505. PubMed PMID: 3037419.

[3] Corda MG, Giorgi O, Longoni B, Mereu GP, Biggio G. Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. J Neurochem. 1987 May;48(5):1355-8. PubMed PMID: 2881979.

[4] Wettstein JG, Spealman RD. Behavioral effects of the beta-carboline derivatives ZK 93423 and ZK 91296 in squirrel monkeys: comparison with lorazepam and suriclone. J Pharmacol Exp Ther. 1987 Feb;240(2):471-5. PubMed PMID: 2879907.

[5] Pellow S, File SE. Evidence that the beta-carboline, ZK 91296, can reduce anxiety in animals at doses well below those causing sedation. Brain Res. 1986 Jan 15;363(1):174-7. PubMed PMID: 2868775.

6: Klockgether T, Schwarz M, Turski L, Sontag KH. ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties. Eur J Pharmacol. 1985 Apr 16;110(3):309-15. PubMed PMID: 2861101.7: Jensen LH, Marescaux C, Vergnes M, Micheletti G, Petersen EN. Antiepileptic action of the beta-carboline ZK 91296 in a genetic petit mal model in rats. Eur J Pharmacol. 1984 Jul 20;102(3-4):521-4. PubMed PMID: 6436039.8: Petersen EN, Jensen LH, Honoré T, Braestrup C, Kehr W, Stephens DN, Wachtel H, Seidelman D, Schmiechen R. ZK 91296, a partial agonist at benzodiazepine receptors. Psychopharmacology (Berl). 1984;83(3):240-8. PubMed PMID: 6089246.9: Meldrum BS, Evans MC, Braestrup C. Anticonvulsant action in the photosensitive baboon, Papio papio, of a novel beta-carboline derivative, ZK 91296. Eur J Pharmacol. 1983 Jul 22;91(2-3):255-9. PubMed PMID: 6311579.

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