172649-40-0|ZD-0947|(S)-3-(5-oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile|-范德生物科技公司

ZD-0947

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names：
(S)-3-(5-oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile
CAS号：
172649-40-0
MDL Number：
MF(分子式)： C17H13F3N2O MW(分子量)： 318.2992
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(S)-3-(5-oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile
英文别名	ZD-0947; AZD-0947; ZD0947; AZD0947; ZD 0947; AZD 0947
CAS号	172649-40-0
Inchi	InChI=1S/C17H13F3N2O/c18-17(19,20)15-8-12(11-4-1-3-10(7-11)9-21)16-13(22-15)5-2-6-14(16)23/h1,3-4,7-8,12,22H,2,5-6H2/t12-/m0/s1
InchiKey	RUVMMEREJMHLOS-LBPRGKRZSA-N
分子式 Formula	C17H13F3N2O
分子量 Molecular Weight	318.2992
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ZD-0947(CAS:172649-40-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ZD-0947, also known as AZD-0947, is a K(ATP) channel activator potentially for the treatment of overactive bladder (OAB).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Mori K, Yamashita Y, Teramoto N. Effects of ZD0947, a novel and potent ATP-sensitive K(+) channel opener, on smooth muscle-type ATP-sensitive K(+) channels. Eur J Pharmacol. 2016 Nov 15;791:773-779. doi: 10.1016/j.ejphar.2016.09.038. PubMed PMID: 27693800.

[2]Yunoki T, Zhu HL, Iwasa K, Tomoda T, Aishima M, Shibata A, Naito S, Teramoto N. Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):309-19. PubMed PMID: 18071674.

[3] Aishima M, Tomoda T, Yunoki T, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N. Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes. Br J Pharmacol. 2006 Nov;149(5):542-50. PubMed PMID: 17016513; PubMed Central PMCID: PMC2014675.

[4] Abdel-Karim AM, Bialecki RA, Elhilali MM. Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats. J Urol. 2002 Aug;168(2):837-42. PubMed PMID: 12131377.

[5] Chapple CR, Patroneva A, Raines SR. Effect of an ATP-sensitive potassium channel opener in subjects with overactive bladder: a randomized, double-blind, placebo-controlled study (ZD0947IL/0004). Eur Urol. 2006 May;49(5):879-86. PubMed PMID: 16517051.

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