83133-14-6|Yuanhuanin|3'-Hydroxygenkwanin 5-O-beta-glucoside|-范德生物科技公司

Yuanhuanin

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names：
3'-Hydroxygenkwanin 5-O-beta-glucoside
CAS号：
83133-14-6
MDL Number：
MF(分子式)： C22H22O11 MW(分子量)： 462.407
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	3'-Hydroxygenkwanin 5-O-beta-glucoside
英文别名	Yuanhuanin;
CAS号	83133-14-6
Inchi	InChI=1S/C22H22O11/c1-30-10-5-15-18(13(26)7-14(31-15)9-2-3-11(24)12(25)4-9)16(6-10)32-22-21(29)20(28)19(27)17(8-23)33-22/h2-7,17,19-25,27-29H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1
InchiKey	ZXVSQQSRCKKYLS-MIUGBVLSSA-N
分子式 Formula	C22H22O11
分子量 Molecular Weight	462.407
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Yuanhuanin(CAS:83133-14-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Yuanhuanin is a biochemical.
Application1
Application2
Application3

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危险性	Warning
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备注

[1]Han BS, Minh NV, Choi HY, Byun JS, Kim WG. Daphnane and Phorbol Diterpenes, Anti-neuroinflammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne genkwa. Biol Pharm Bull. 2017;40(12):2205-221[1]doi: 10.1248/bpb.b17-0064[1]PubMed PMID: 29199243.

[2]Li M, Liu X, Cai H, Shen Z, Xu L, Li W, Wu L, Duan J, Chen Z. Validation and Application of an Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry Method for Yuanhuacine Determination in Rat Plasma after Pulmonary Administration: Pharmacokinetic Evaluation of a New Drug Delivery System. Molecules. 2016 Dec 16;21(12). pii: E1733. doi: 10.3390/molecules21121733. PubMed PMID: 27999290.

[3] Han BS, Kim KS, Kim YJ, Jung HY, Kang YM, Lee KS, Sohn MJ, Kim CH, Kim KS, Kim WG. Daphnane Diterpenes from Daphne genkwa Activate Nurr1 and Have a Neuroprotective Effect in an Animal Model of Parkinson's Disease. J Nat Prod. 2016 Jun 24;79(6):1604-9. doi: 10.1021/acs.jnatprod.6b00110. Epub 2016 May 26. PubMed PMID: 27228307; PubMed Central PMCID: PMC5635821.

[4] Li L, Yin FZ, Lu TL, Guan HY, Cai BC. [Fingerprint of Vinegar Processed Genkwa Flos Based on Improving Euclidean Distance]. Zhong Yao Cai. 2015 Jun;38(6):1168-71. Chinese. PubMed PMID: 26762055.

[5] Kang JI, Hong JY, Lee HJ, Bae SY, Jung C, Park HJ, Lee SK. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. doi: 10.1371/journal.pone.0144368. eCollection 2015. PubMed PMID: 26656173; PubMed Central PMCID: PMC4676678.

6: Zhang R, Wang Y, Li J, Jin H, Song S, Huang C. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403. doi: 10.1074/jbc.M113.513960. Epub 2014 Jan 22. PubMed PMID: 24451377; PubMed Central PMCID: PMC3945306.7: Chen YY, Qian DW, Shang EX, Qian YF, Liu P, Su SL, Guo JM, Tang YP, Duan JA. [The incompatibility mechanism based on the interaction of multiple-components for Flos Genkwa and Radix et Rhizoma Glycyrrhizae]. Yao Xue Xue Bao. 2012 Aug;47(8):1043-8. Chinese. PubMed PMID: 23162902.8: Hong JY, Nam JW, Seo EK, Lee SK. Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa. Chem Pharm Bull (Tokyo). 2010 Feb;58(2):234-7. PubMed PMID: 20118586.9: Zhang S, Gao X, Shen K, Yang P, Ju X. Evaluation of poly(D,L-lactide-co-glycolide) microspheres for the lung-targeting of yuanhuacine, a novel DNA topoisomerase I inhibitor. J Drug Target. 2009 May;17(4):286-93. doi: 10.1080/10611860902737912. PubMed PMID: 19558356.10: Zhang SX, Yang PW, Zhang DC, Dong WQ, Zhang FH, Sun YM. Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit. Xenobiotica. 2009 Mar;39(3):273-81. doi: 10.1080/00498250802715987. PubMed PMID: 19280526.1

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