851331-05-0|YM-53403|6-(4-([1,1'-biphenyl]-2-carboxamido)benzoyl)-N-cyclopropyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide|-范德生物科技公司

YM-53403

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names：
6-(4-([1,1'-biphenyl]-2-carboxamido)benzoyl)-N-cyclopropyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide
CAS号：
851331-05-0
MDL Number：
MF(分子式)： C36H29N3O3S MW(分子量)： 583.706
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	6-(4-([1,1'-biphenyl]-2-carboxamido)benzoyl)-N-cyclopropyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide
英文别名	YM-53403; YM 53403; YM53403
CAS号	851331-05-0
Inchi	InChI=1S/C36H29N3O3S/c40-34(29-11-5-4-10-28(29)23-8-2-1-3-9-23)37-26-16-14-24(15-17-26)36(42)39-21-20-25-22-32(35(41)38-27-18-19-27)43-33(25)30-12-6-7-13-31(30)39/h1-17,22,27H,18-21H2,(H,37,40)(H,38,41)
InchiKey	LNZINXTYRHOGTA-UHFFFAOYSA-N
分子式 Formula	C36H29N3O3S
分子量 Molecular Weight	583.706
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	YM-53403(CAS:851331-05-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	YM-53403 is a respiratory syncytial virus (RSV) inhibitor. YM-53403 potently inhibited the replication of RSV strains belonging to both A and B subgroups, but not influenza A virus, measles virus, or herpes simplex virus type 1. A plaque reduction assay was used to determine the 50% effective concentration (EC(50)) value for YM-53403. The value, 0.20 microM, was about 100-fold more potent than ribavirin. YM-53403 is an attractive compound for the treatment of RSV infection because of its highly potent anti-RSV activity and the new mode of action, which differs from that of currently reported antiviral agents.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tiong-Yip CL, Aschenbrenner L, Johnson KD, McLaughlin RE, Fan J, Challa S, Xiong H, Yu Q. Characterization of a respiratory syncytial virus L protein inhibitor. Antimicrob Agents Chemother. 2014 Jul;58(7):3867-73. doi: 10.1128/AAC.02540-14. Epub 2014 Apr 28. PubMed PMID: 24777090; PubMed Central PMCID: PMC4068518.

[2]Sudo K, Miyazaki Y, Kojima N, Kobayashi M, Suzuki H, Shintani M, Shimizu Y. YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action. Antiviral Res. 2005 Feb;65(2):125-31. PubMed PMID: 15708639.

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