343247-32-5|XR 5944|N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide)|-范德生物科技公司

XR 5944

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names：
N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide)
CAS号：
343247-32-5
MDL Number：
MF(分子式)： C34H34N8O2 MW(分子量)： 586.7
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide)
英文别名	XR 5944; XR-5944; XR5944 ; MLN 944; MLN-944; MLN944
CAS号	343247-32-5
SMILES	O=C(C1=CC=CC2=NC3=CC=CC(C)=C3N=C21)NCCNCCNCCNC(C4=CC=CC5=NC6=CC=CC(C)=C6N=C54)=O
Inchi	InChI=1S/C34H34N8O2/c1-21-7-3-11-25-29(21)41-31-23(9-5-13-27(31)39-25)33(43)37-19-17-35-15-16-36-18-20-38-34(44)24-10-6-14-28-32(24)42-30-22(2)8-4-12-26(30)40-28/h3-14,35-36H,15-20H2,1-2H3,(H,37,43)(H,38,44)
InchiKey	SFOADSRLCHRTKT-UHFFFAOYSA-N
分子式 Formula	C34H34N8O2
分子量 Molecular Weight	586.7
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	XR 5944(CAS:343247-32-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	XR 5944 is a potent DNA binding agent which stabilizes topoisomerase-dependent cleavage, thereby demonstrating exceptional efficacy against a number of murine and human tumor models.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lin C, Yang D. DNA Recognition by a Novel Bis-Intercalator, Potent Anticancer Drug XR5944. Curr Top Med Chem. 2015;15(14):1385-97. Review. PubMed PMID: 25866279; PubMed Central PMCID: PMC4772870.

[2]Lin C, Mathad RI, Zhang Z, Sidell N, Yang D. Solution structure of a

2:1 complex of anticancer drug XR5944 with TFF1 estrogen response element: insights into DNA recognition by a bis-intercalator. Nucleic Acids Res. 2014 May;42(9):6012-24. doi: 10.1093/nar/gku219. Epub 2014 Apr 7. PubMed PMID: 24711371; PubMed Central PMCID: PMC4027214.

[4]Moorthy NS, Pratheepa V, Ramos MJ, Vasconcelos V, Fernandes PA. Fused aryl-phenazines: scaffold for the development of bioactive molecules. Curr Drug Targets. 2014;15(7):681-8. Review. PubMed PMID: 24499398.

[5] Sidell N, Mathad RI, Shu FJ, Zhang Z, Kallen CB, Yang D. Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites. J Steroid Biochem Mol Biol. 2011 Apr;124(3-5):121-7. doi: 10.1016/j.jsbmb.2011.02.003. Epub 2011 Feb 17. PubMed PMID: 21333738; PubMed Central PMCID: PMC3072055.

5: Wolf SJ, Wakelin LP, He Z, Stewart BW, Catchpoole DR. In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines. Cancer Chemother Pharmacol. 2009 Nov;64(6):1059-69. doi: 10.1007/s00280-009-0962-4. Epub 2009 Mar 10. PubMed PMID: 19277661.

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