343247-32-5|XR 5944|N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide)|-范德生物科技公司

XR 5944

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names：
N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide)
CAS号：
343247-32-5
MDL Number：
MF(分子式)： C34H34N8O2 MW(分子量)： 586.7
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide)
英文别名	XR 5944; XR-5944; XR5944 ; MLN 944; MLN-944; MLN944
CAS号	343247-32-5
Inchi	InChI=1S/C34H34N8O2/c1-21-7-3-11-25-29(21)41-31-23(9-5-13-27(31)39-25)33(43)37-19-17-35-15-16-36-18-20-38-34(44)24-10-6-14-28-32(24)42-30-22(2)8-4-12-26(30)40-28/h3-14,35-36H,15-20H2,1-2H3,(H,37,43)(H,38,44)
InchiKey	SFOADSRLCHRTKT-UHFFFAOYSA-N
分子式 Formula	C34H34N8O2
分子量 Molecular Weight	586.7
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	XR 5944(CAS:343247-32-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	XR 5944 is a potent DNA binding agent which stabilizes topoisomerase-dependent cleavage, thereby demonstrating exceptional efficacy against a number of murine and human tumor models.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lin C, Yang D. DNA Recognition by a Novel Bis-Intercalator, Potent Anticancer Drug XR5944. Curr Top Med Chem. 2015;15(14):1385-97. Review. PubMed PMID: 25866279; PubMed Central PMCID: PMC4772870.

[2]Lin C, Mathad RI, Zhang Z, Sidell N, Yang D. Solution structure of a

2:1 complex of anticancer drug XR5944 with TFF1 estrogen response element: insights into DNA recognition by a bis-intercalator. Nucleic Acids Res. 2014 May;42(9):6012-24. doi: 10.1093/nar/gku219. Epub 2014 Apr 7. PubMed PMID: 24711371; PubMed Central PMCID: PMC4027214.

[4]Moorthy NS, Pratheepa V, Ramos MJ, Vasconcelos V, Fernandes PA. Fused aryl-phenazines: scaffold for the development of bioactive molecules. Curr Drug Targets. 2014;15(7):681-8. Review. PubMed PMID: 24499398.

[5] Sidell N, Mathad RI, Shu FJ, Zhang Z, Kallen CB, Yang D. Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites. J Steroid Biochem Mol Biol. 2011 Apr;124(3-5):121-7. doi: 10.1016/j.jsbmb.2011.02.003. Epub 2011 Feb 17. PubMed PMID: 21333738; PubMed Central PMCID: PMC3072055.

5: Wolf SJ, Wakelin LP, He Z, Stewart BW, Catchpoole DR. In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines. Cancer Chemother Pharmacol. 2009 Nov;64(6):1059-69. doi: 10.1007/s00280-009-0962-4. Epub 2009 Mar 10. PubMed PMID: 19277661.

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