82059-29-8|Wy 26392|N-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-N-methylpropane-1-sulfonamide;hydrochloride|-范德生物科技公司

Wy 26392

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names：
N-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-N-methylpropane-1-sulfonamide;hydrochloride
CAS号：
82059-29-8
MDL Number：
MF(分子式)： C17H27ClN2O2S MW(分子量)： 358.925
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-N-methylpropane-1-sulfonamide;hydrochloride
英文别名	Wy 26392; Wy26392; Wy-26392
CAS号	82059-29-8
Inchi	InChI=1S/C17H26N2O2S.ClH/c1-3-12-22(20,21)18(2)15-9-11-19-10-8-14-6-4-5-7-16(14)17(19)13-15;/h4-7,15,17H,3,8-13H2,1-2H3;1H/t15?,17-;/m1./s1
InchiKey	PAXYOGKTTMRRMP-PKESZJFOSA-N
分子式 Formula	C17H27ClN2O2S
分子量 Molecular Weight	358.925
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Wy 26392(CAS:82059-29-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Wy 26392 is an alpha 2 adrenoceptors antagonist that increase central sympathetic tone and blood pressure in low doses.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Ramage AG, Tomlinson A. The effect of yohimbine, WY 26392 and idazoxan on sympathetic nerve activity. Eur J Pharmacol. 1985 Feb 26;109(2):153-60. PubMed PMID: 2859996.

[3] Ramage AG. The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors. Br J Pharmacol. 1991 Apr;102(4):998-1002. PubMed PMID: 1855130; PubMed Central PMCID: PMC1917978.

[4] Jurcovicová J, Le T, Krulich L. The paradox of alpha 2 adrenergic regulation of prolactin (PRL) secretion. II. PRL-releasing action of the alpha 2 receptor antagonists. Brain Res Bull. 1989 Dec;23(6):425-32. PubMed PMID: 2575440.

[5] Fozard JR, Mir AK, Middlemiss DN. Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis. J Cardiovasc Pharmacol. 1987 Mar;9(3):328-47. PubMed PMID: 2437400.

6: Bill DJ, Hughes IE, Stephens RJ. The thermogenic actions of alpha 2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic alpha 2-adrenoceptor mechanism. Br J Pharmacol. 1989 Jan;96(1):133-43. PubMed PMID: 2564288; PubMed Central PMCID: PMC1854293.7: Hamilton CA, Reid JL, Yakubu MA. [3H]yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes. Eur J Pharmacol. 1988 Feb 9;146(2-3):345-8. PubMed PMID: 3371405.8: Berthold H, Fozard JR, Engel G. 5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice. Eur J Pharmacol. 1989 Mar 14;162(1):19-27. PubMed PMID: 2566495.9: Dickinson KE, McKernan RM, Miles CM, Leys KS, Sever PS. Heterogeneity of mammalian alpha 2-adrenoceptors delineated by [3H]yohimbine binding. Eur J Pharmacol. 1986 Jan 29;120(3):285-93. PubMed PMID: 3005004.10: Gower AJ, Tricklebank MD. Alpha 2-adrenoceptor antagonist activity may account for the effects of buspirone in an anticonflict test in the rat. Eur J Pharmacol. 1988 Oct 11;155(1-2):129-37. PubMed PMID: 2907485.1

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