75808-67-2|VV-Hemorphin-7|L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine|-范德生物科技公司

VV-Hemorphin-7

NMR下载 COA and HPLC MSDS下载
names：
L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine
CAS号：
75808-67-2
MDL Number：
MF(分子式)： C59H82N14O13 MW(分子量)： 1195.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine
英文别名	VV-Hemorphin-7; Val-val-tyr-pro-trp-thr-gln-arg-phe;
CAS号	75808-67-2
SMILES	O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H]([C@H](O)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H]4N(C([C@H](CC5=CC=C(O)C=C5)NC([C@H](C(C)C)NC([C@H](C(C)C)N)=O)=O)=O)CCC4)=O)=O)=O)=O)=O
Inchi	InChI=1S/C59H82N14O13/c1-31(2)47(61)54(81)71-48(32(3)4)55(82)69-43(27-35-19-21-37(75)22-20-35)57(84)73-26-12-18-45(73)53(80)68-42(29-36-30-65-39-16-10-9-15-38(36)39)52(79)72-49(33(5)74)56(83)67-41(23-24-46(60)76)51(78)66-40(17-11-25-64-59(62)63)50(77)70-44(58(85)86)28-34-13-7-6-8-14-34/h6-10,13-16,19-22,30-33,40-45,47-49,65,74-75H,11-12,17-18,23-29,61H2,1-5H3,(H2,60,76)(H,66,78)(H,67,83)(H,68,80)(H,69,82)(H,70,77)(H,71,81)(H,72,79)(H,85,86)(H4,62,63,64)/t33-,40+,41+,42+,43+,44+,45+,47+,48+,49+/m1/s1
InchiKey	FFBBHLKDMHCFTH-AKYHLAPZSA-N
分子式 Formula	C59H82N14O13
分子量 Molecular Weight	1195.39
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	VV-Hemorphin-7(CAS:75808-67-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	VV-Hemorphin-7 is a morphinomimetic peptide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Fruitier I, Garreau I, Piot JM. Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo: VV-hemorphin-7. Biochem Biophys Res Commun. 1998 May 29;246(3):719-24. PubMed PMID: 9618278.

[2]Maraninchi M, Feron D, Fruitier-Arnaudin I, Bégu-Le Corroller A, Nogueira JP, Mancini J, Valéro R, Piot JM, Vialettes B. Serum hemorphin-7 levels are decreased in obesity. Obesity (Silver Spring). 2013 Feb;21(2):378-81. doi: 10.1002/oby.20280. PubMed PMID: 23532992.

[3] Desiderio C, D'Angelo L, Rossetti DV, Iavarone F, Giardina B, Castagnola M, Massimi L, Tamburrini G, Di Rocco C. Cerebrospinal fluid top-down proteomics evidenced the potential biomarker role of LVV- and VV-hemorphin-7 in posterior cranial fossa pediatric brain tumors. Proteomics. 2012 Jul;12(13):2158-66. doi: 10.1002/pmic.201100499. Epub 2012 Jun 18. PubMed PMID: 22623401.

[4] Dagouassat N, Garreau I, Sannier F, Zhao Q, Piot JM. Generation of VV-hemorphin-7 from globin by peritoneal macrophages. FEBS Lett. 1996 Mar 11;382(1-2):37-42. PubMed PMID: 8612760.

[5] Dagouassat N, Garreau I, Zhao Q, Sannier F, Piot JM. Kinetic of in vitro generation of some hemorphins: early release of LVV-hemorphin-7, precursor of VV-hemorphin-7. Neuropeptides. 1996 Feb;30(1):1-5. PubMed PMID: 8868292.

6: Garreau I, Zhao Q, Pejoan C, Cupo A, Piot JM. VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides. Neuropeptides. 1995 Apr;28(4):243-50. PubMed PMID: 7596489.7: Szikra J, Benyhe S, Orosz G, Darula Z, Piot JM, Fruitier I, Monory K, Hanoune J, Borsodi A. Radioligand binding properties of VV-hemorphin 7, an atypical opioid peptide. Biochem Biophys Res Commun. 2001 Mar 2;281(3):670-7. PubMed PMID: 11237710.8: Cohen M, Fruitier-Arnaudin I, Sauvan R, Birnbaum D, Piot JM. Serum levels of Hemorphin-7 peptides in patients with breast cancer. Clin Chim Acta. 2003 Nov;337(1-2):59-67. PubMed PMID: 14568181.9: Yatskin ON, Philippova MM, Blishchenko EYu, Karelin AA, Ivanov VT. LVV- and VV-hemorphins: comparative levels in rat tissues. FEBS Lett. 1998 May 29;428(3):286-90. PubMed PMID: 9654150.10: Lammerich HP, Busmann A, Kutzleb C, Wendland M, Seiler P, Berger C, Eickelmann P, Meyer M, Forssmann WG, Maronde E. Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3. Br J Pharmacol. 2003 Apr;138(8):1431-40. PubMed PMID: 12721098; PubMed Central PMCID: PMC1573796.1

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