688737-89-5|Tyropeptin A-4|(2S)-2-((2S)-2-(2-cyclohexylacetamido)-3-(4-hydroxyphenyl)-N-(1-(4-hydroxyphenyl)-3-oxopropan-2-yl)propanamido)-3-methylbutanamide|-范德生物科技公司

Tyropeptin A-4

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names：
(2S)-2-((2S)-2-(2-cyclohexylacetamido)-3-(4-hydroxyphenyl)-N-(1-(4-hydroxyphenyl)-3-oxopropan-2-yl)propanamido)-3-methylbutanamide
CAS号：
688737-89-5
MDL Number：
MF(分子式)： C31H41N3O6 MW(分子量)： 551.68
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2S)-2-((2S)-2-(2-cyclohexylacetamido)-3-(4-hydroxyphenyl)-N-(1-(4-hydroxyphenyl)-3-oxopropan-2-yl)propanamido)-3-methylbutanamide
英文别名	Tyropeptin A-4; Tyropeptin A 4; Tyropeptin A4; TP-101; TP 101; TP101;
CAS号	688737-89-5
SMILES	CC(C)[C@@H](C(N)=O)N(C([C@H](CC1=CC=C(O)C=C1)NC(CC2CCCCC2)=O)=O)C(C=O)CC3=CC=C(O)C=C3
Inchi	InChI=1S/C31H41N3O6/c1-20(2)29(30(32)39)34(24(19-35)16-22-8-12-25(36)13-9-22)31(40)27(17-23-10-14-26(37)15-11-23)33-28(38)18-21-6-4-3-5-7-21/h8-15,19-21,24,27,29,36-37H,3-7,16-18H2,1-2H3,(H2,32,39)(H,33,38)/t24?,27-,29-/m0/s1
InchiKey	OHEAMPJRQIBBHO-TXJYOHDVSA-N
分子式 Formula	C31H41N3O6
分子量 Molecular Weight	551.68
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tyropeptin A-4(CAS:688737-89-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tyropeptin A-4 is a proteasome inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, Yamori T, Masuda T, Nomoto A. Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors. Cancer Sci. 2014 Dec;105(12):1609-15. doi: 10.1111/cas.12542. Epub 2014 Oct 2[1]PubMed PMID: 25251038; PubMed Central PMCID: PMC4317970.

[2]Watanabe T, Abe H, Momose I, Takahashi Y, Ikeda D, Akamatsu Y. Structure-activity relationship of boronic acid derivatives of tyropeptin: proteasome inhibitors. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5839-42. doi: 10.1016/j.bmcl.2010.07.122. Epub 2010 Aug 1. PubMed PMID: 20727746.

[3] Steverding D, Pemberton AJ, Royle H, Spackman RW, Rivett AJ. Evaluation of the anti-trypanosomal activity of tyropeptin A. Planta Med. 2006 Jun;72(8):761-3. Epub 2006 May 29. PubMed PMID: 16732530.

[4] Momose I, Umezawa Y, Hirosawa S, Iinuma H, Ikeda D. Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1867-71. PubMed PMID: 15780623.

[5] Momose I, Sekizawa R, Iinuma H, Takeuchi T. Inhibition of proteasome activity by tyropeptin A in PC12 cells. Biosci Biotechnol Biochem. 2002 Oct;66(10):2256-8. PubMed PMID: 12450145.

6: Momose I, Umezawa Y, Hirosawa S, Iijima M, Iinuma H, Ikeda D. Synthesis and activity of tyropeptin A derivatives as potent and selective inhibitors of mammalian 20S proteasome. Biosci Biotechnol Biochem. 2005 Sep;69(9):1733-42. PubMed PMID: 16195592.7: Watanabe T, Momose I, Abe M, Abe H, Sawa R, Umezawa Y, Ikeda D, Takahashi Y, Akamatsu Y. Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2343-5. doi: 10.1016/j.bmcl.2009.02.117. Epub 2009 Mar 4. PubMed PMID: 19307118.8: Liu J, Zhang H, Xiao Z, Wang F, Wang X, Wang Y. Combined 3D-QSAR, molecular docking and molecular dynamics study on derivatives of peptide epoxyketone and tyropeptin-boronic acid as inhibitors against the β5 subunit of human 20S proteasome. Int J Mol Sci. 2011;12(3):1807-35. doi: 10.3390/ijms12031807. Epub 2011 Mar 9. PubMed PMID: 21673924; PubMed Central PMCID: PMC3111635.9: Momose I, Sekizawa R, Hashizume H, Kinoshita N, Homma Y, Hamada M, Iinuma H, Takeuchi T. Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2. I. Taxonomy, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 2001 Dec;54(12):997-1003. PubMed PMID: 11858671.10: Momose I, Iijima M, Kawada M, Ikeda D. A new proteasome inhibitor, TP-110, induces apoptosis in human prostate cancer PC-3 cells. Biosci Biotechnol Biochem. 2007 Apr;71(4):1036-43. Epub 2007 Apr 7. PubMed PMID: 17420589.1

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