76352-13-1|Tropapride|Benzamide, 2,3-dimethoxy-N-((3-exo)-8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-|-范德生物科技公司

Tropapride

NMR下载 COA and HPLC MSDS下载
names：
Benzamide, 2,3-dimethoxy-N-((3-exo)-8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-
CAS号：
76352-13-1
MDL Number：
MF(分子式)： C23H28N2O3 MW(分子量)： 380.488
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Benzamide, 2,3-dimethoxy-N-((3-exo)-8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-
英文别名	Tropapride
CAS号	76352-13-1
SMILES	O=C(NC1CC(N2CC3=CC=CC=C3)CCC2C1)C4=CC=CC(OC)=C4OC
Inchi	InChI=1S/C23H28N2O3/c1-27-21-10-6-9-20(22(21)28-2)23(26)24-17-13-18-11-12-19(14-17)25(18)15-16-7-4-3-5-8-16/h3-10,17-19H,11-15H2,1-2H3,(H,24,26)
InchiKey	PCIWCYUKRZFCMF-UHFFFAOYSA-N
分子式 Formula	C23H28N2O3
分子量 Molecular Weight	380.488
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tropapride(CAS:76352-13-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tropapride is a benzamide derivative.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Collin S, Vercauteren DP, Vanderveken D, Evrard G, Durant F. Structural requirements of Na+-dependent antidopaminergic agents: Tropapride, Piquindone, Zetidoline, and Metoclopramide. Comparison with Na+-independent ligands. J Comput Aided Mol Des. 1989 Mar;3(1):39-53. PubMed PMID: 2715795.

[3] Damhaut P, Cantineau R, Lemaire C, Plenevaux A, Christiaens L, Guillaume M. 2- and 4-[18F]fluorotropapride, two specific D2 receptor ligands for positron emission tomography: N.C.A. syntheses and animal studies. Int J Rad Appl Instrum A. 1992 Oct;43(10):1265-74. PubMed PMID: 1330979.

[4] Rumigny JF, Strolin Benedetti M, Dostert P. Investigation on central dopaminergic receptors (D-2) using the antagonistic properties of new benzamides. J Pharm Pharmacol. 1984 Jun;36(6):373-7. PubMed PMID: 6146667.

[5] Wurch T, Boutet-Robinet EA, Palmier C, Colpaert FC, Pauwels PJ. Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs. J Pharmacol Exp Ther. 2003 Jan;304(1):380-90. PubMed PMID: 12490615.

6: Prinssen EP, Kleven MS, Koek W. Interactions between neuroleptics and 5-HT(1A) ligands in preclinical behavioral models for antipsychotic and extrapyramidal effects. Psychopharmacology (Berl). 1999 May;144(1):20-9. PubMed PMID: 10379620.7: Pauwels PJ, Koek W. Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jan;365(1):82-5. Epub 2001 Oct 31. PubMed PMID: 11862337.8: Jalfre M, Bucher B, Dorme N, Mocquet G, Porsolt RD. Neuropharmacological profile of MD 790501, a new benzamide derivative. Arch Int Pharmacodyn Ther. 1983 Aug;264(2):232-56. PubMed PMID: 6139097.9: Pauwels PJ, Finana F, Tardif S, Wurch T, Colpaert FC. Dynamic dopamine-antagonist interactions at recombinant human dopamine D(2short) receptor: dopamine-bound versus antagonist-bound receptor states. J Pharmacol Exp Ther. 2001 Apr;297(1):133-40. PubMed PMID: 11259537.

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