53746-46-6|Trimazosin hydrochloride|2-hydroxy-2-methylpropyl 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate hydrochloride hydrate|-范德生物科技公司

Trimazosin hydrochloride

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names：
2-hydroxy-2-methylpropyl 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate hydrochloride hydrate
CAS号：
53746-46-6
MDL Number：
MF(分子式)： C20H32ClN5O7 MW(分子量)： 489.954
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2-hydroxy-2-methylpropyl 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate hydrochloride hydrate
英文别名	CP-19106-1; CP19106-1; CP 19106-1; Trimazosin hydrochloride; Trimazosin HCl.
CAS号	53746-46-6
Inchi	InChI=1S/C20H29N5O6.ClH.H2O/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5;;/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23);1H;1H2
InchiKey	WXMXALSEIGHTOR-UHFFFAOYSA-N
分子式 Formula	C20H32ClN5O7
分子量 Molecular Weight	489.954
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Trimazosin hydrochloride(CAS:53746-46-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Trimazosin hydrochloride is used in the treatment of hypertensive patients failing to respond to thiazides.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Vincent J, Hamilton CA, Reid JL. The cardiovascular effects of trimazosin and prazosin in the rabbit. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):593-608. PubMed PMID: 2878751.

[2]Moyer RR. A double-blind study of trimazosin and methyldopa in hypertensive patients receiving polythiazide. Am Heart J. 1983 Nov;106(5 Pt 2):1250-3. PubMed PMID: 6356853.

[3] Constantine JW, Lebel W, Weeks R. The hypotensive effect of trimazosin is not caused solely by alpha 1-adrenoceptor blockade. J Cardiovasc Pharmacol. 1984 Jan-Feb;6(1):142-50. PubMed PMID: 6199597.

[4] Singleton W, Taylor CR. Effect of trimazosin on serum lipid profiles in hypertensive patients. Am Heart J. 1983 Nov;106(5 Pt 2):1265-8. PubMed PMID: 6356856.

[5] Helgeland A. Double-blind comparison of trimazosin and propranolol in essential hypertension. Am Heart J. 1983 Nov;106(5 Pt 2):1253-8. PubMed PMID: 6356854.

6: Vincent J, Elliott HL, Meredith PA, Reid JL. Trimazosin: relationships between hypotensive effect, vascular responsiveness, and drug and metabolite concentrations. J Cardiovasc Pharmacol. 1985 Sep-Oct;7(5):913-8. PubMed PMID: 2413300.7: Vincent J, Elliott HL, Meredith PA, Hughes DM, Reid JL. The effect of cimetidine on the pharmacokinetics, pharmacodynamics and alpha 1-adrenoceptor responsiveness of trimazosin in man. Eur J Clin Pharmacol. 1985;29(3):301-6. PubMed PMID: 3000797.8: Reid JL, Meredith PA, Elliott HL. Pharmacokinetics and pharmacodynamics of trimazosin in man. Am Heart J. 1983 Nov;106(5 Pt 2):1222-8. PubMed PMID: 6637788.9: Oberman A, Pool PE. Trimazosin for the treatment of hypertensive patients failing to respond to thiazides. Am Heart J. 1983 Nov;106(5 Pt 2):1258-64. PubMed PMID: 6356855.10: Weber MA, Brewer DD, Drayer JI, Aronow WS, Lipson JL, Ricci BA. A vasodilator that avoids renin stimulation and fluid retention: antihypertensive treatment with trimazosin. Clin Pharmacol Ther. 1982 May;31(5):572-8. PubMed PMID: 7042174.1

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