54974-54-8|TRH tartrate|(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate|-范德生物科技公司

TRH tartrate

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names：
(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate
CAS号：
54974-54-8
MDL Number：
MF(分子式)： C20H28N6O10 MW(分子量)： 512.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate
英文别名	TRH tartrate;
CAS号	54974-54-8
Inchi	InChI=1S/C16H22N6O4.C4H6O6/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10;5-1(3(7)8)2(6)4(9)10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25);1-2,5-6H,(H,7,8)(H,9,10)/t10-,11-,12-;1-,2-/m01/s1
InchiKey	KPUAAIHTPMAPLR-GJAJEHNISA-N
分子式 Formula	C20H28N6O10
分子量 Molecular Weight	512.47
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TRH tartrate(CAS:54974-54-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TRH tartrate is a thyrotropin-releasing hormone.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nihei N, Ikeda Y, Murata Y, Kamikawa T, Suzuki Y, Yamazaki N. [Changes of plasma levels of TRH and its target hormones by two hour constant intravenous infusion of TRH tartrate in man (author's transl)]. Nihon Naibunpi Gakkai Zasshi. 1979 Sep 20;55(9):1089-97. Japanese. PubMed PMID: 115728.

[2]Ogashiwa M, Takeuchi K. Clinical studies of thyrotropin-releasing hormone tartrate (TRH-T) as a direct stimulant to the central nervous system. Int J Clin Pharmacol Biopharm. 1979 Apr;17(4):145-51. PubMed PMID: 36357.

[3] Yokohama S, Yamashita K, Toguchi H, Takeuchi J, Kitamori N. Absorption of thyrotropin-releasing hormone after oral administration of TRH tartrate monohydrate in the rat, dog and human. J Pharmacobiodyn. 1984 Feb;7(2):101-11. PubMed PMID: 6427443.

[4] Chujo T, Sakata K, Yamada H, Sakai N, Sumi Y, Nishimura Y, Tanaka S, Ito T, Ohmae K, Nonomura O, Ohshita H, Nishiwaki T, Hirose A, Arima T, Takegoshi T. [Experimental and clinical studies on thyrotropin releasing hormone tartrate (TRH-T) for treatment of disturbances of consciousness (author's transl)]. Neurol Med Chir (Tokyo). 1980 Mar;20(3):289-301. Japanese. PubMed PMID: 6155639.

[5] Yoshida N, Shimizu N, Demura R, Shizume K, Iino S. [Study of TRH tartrate as a diagnostic agent--cross comparison with TRH in a double blind test]. Horumon To Rinsho. 1976 Dec;24(12):1285-92. Japanese. PubMed PMID: 828566.

6: Wakabayashi K, Demura R, Kanda M, Demura H, Fujino R. [Clinical experience using TRH-tartrate]. Horumon To Rinsho. 1976 Oct;24(10):1063-72. Japanese. PubMed PMID: 827401.7: Manaka S, Sano K. Thyrotropin-Releasing Hormone tartrate (TRH-T) shortens concussion effects following head impact in mice. Neurosci Lett. 1978 Jun;8(3):255-8. PubMed PMID: 19605168.8: Miyoshi M, Takahara J, Miura H, Yamauchi J, Nakajima Y. [Changes of various hormones in successive administration of TRH-tartrate (TRH-T) (author's transl)]. Horumon To Rinsho. 1979 Sep;27(9):1055-62. Japanese. PubMed PMID: 118831.9: Ogawa T, Moriwake T, Morimoto K, Sato M, Otsuki S. [The effect of a novel TRH analog (DN-1417) on postictal seizure inhibition in amygdaloid kindled cats]. No To Shinkei. 1984 Oct;36(10):951-5. Japanese. PubMed PMID: 6440585.10: Hatanaka C, Obayashi M, Nishimura O, Toukai N, Fujino M. An improved synthesis of thyrotropin releasing hormone (TRH) and crystallization of the tartrate. Biochem Biophys Res Commun. 1974 Oct 23;60(4):1345-50. PubMed PMID: 4153890.1

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