54974-54-8|TRH tartrate|(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate|-范德生物科技公司

TRH tartrate

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names：
(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate
CAS号：
54974-54-8
MDL Number：
MF(分子式)： C20H28N6O10 MW(分子量)： 512.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide (2R,3R)-2,3-dihydroxysuccinate
英文别名	TRH tartrate;
CAS号	54974-54-8
SMILES	O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CC3)NC3=O)=O)=O)CCC1.O=C(O)[C@H](O)[C@@H](O)C(O)=O
Inchi	InChI=1S/C16H22N6O4.C4H6O6/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10;5-1(3(7)8)2(6)4(9)10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25);1-2,5-6H,(H,7,8)(H,9,10)/t10-,11-,12-;1-,2-/m01/s1
InchiKey	KPUAAIHTPMAPLR-GJAJEHNISA-N
分子式 Formula	C20H28N6O10
分子量 Molecular Weight	512.47
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TRH tartrate(CAS:54974-54-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TRH tartrate is a thyrotropin-releasing hormone.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nihei N, Ikeda Y, Murata Y, Kamikawa T, Suzuki Y, Yamazaki N. [Changes of plasma levels of TRH and its target hormones by two hour constant intravenous infusion of TRH tartrate in man (author's transl)]. Nihon Naibunpi Gakkai Zasshi. 1979 Sep 20;55(9):1089-97. Japanese. PubMed PMID: 115728.

[2]Ogashiwa M, Takeuchi K. Clinical studies of thyrotropin-releasing hormone tartrate (TRH-T) as a direct stimulant to the central nervous system. Int J Clin Pharmacol Biopharm. 1979 Apr;17(4):145-51. PubMed PMID: 36357.

[3] Yokohama S, Yamashita K, Toguchi H, Takeuchi J, Kitamori N. Absorption of thyrotropin-releasing hormone after oral administration of TRH tartrate monohydrate in the rat, dog and human. J Pharmacobiodyn. 1984 Feb;7(2):101-11. PubMed PMID: 6427443.

[4] Chujo T, Sakata K, Yamada H, Sakai N, Sumi Y, Nishimura Y, Tanaka S, Ito T, Ohmae K, Nonomura O, Ohshita H, Nishiwaki T, Hirose A, Arima T, Takegoshi T. [Experimental and clinical studies on thyrotropin releasing hormone tartrate (TRH-T) for treatment of disturbances of consciousness (author's transl)]. Neurol Med Chir (Tokyo). 1980 Mar;20(3):289-301. Japanese. PubMed PMID: 6155639.

[5] Yoshida N, Shimizu N, Demura R, Shizume K, Iino S. [Study of TRH tartrate as a diagnostic agent--cross comparison with TRH in a double blind test]. Horumon To Rinsho. 1976 Dec;24(12):1285-92. Japanese. PubMed PMID: 828566.

6: Wakabayashi K, Demura R, Kanda M, Demura H, Fujino R. [Clinical experience using TRH-tartrate]. Horumon To Rinsho. 1976 Oct;24(10):1063-72. Japanese. PubMed PMID: 827401.7: Manaka S, Sano K. Thyrotropin-Releasing Hormone tartrate (TRH-T) shortens concussion effects following head impact in mice. Neurosci Lett. 1978 Jun;8(3):255-8. PubMed PMID: 19605168.8: Miyoshi M, Takahara J, Miura H, Yamauchi J, Nakajima Y. [Changes of various hormones in successive administration of TRH-tartrate (TRH-T) (author's transl)]. Horumon To Rinsho. 1979 Sep;27(9):1055-62. Japanese. PubMed PMID: 118831.9: Ogawa T, Moriwake T, Morimoto K, Sato M, Otsuki S. [The effect of a novel TRH analog (DN-1417) on postictal seizure inhibition in amygdaloid kindled cats]. No To Shinkei. 1984 Oct;36(10):951-5. Japanese. PubMed PMID: 6440585.10: Hatanaka C, Obayashi M, Nishimura O, Toukai N, Fujino M. An improved synthesis of thyrotropin releasing hormone (TRH) and crystallization of the tartrate. Biochem Biophys Res Commun. 1974 Oct 23;60(4):1345-50. PubMed PMID: 4153890.1

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