110072-15-6|Tosagestin|17-Hydroxy-11-methylene-19-nor-17alpha-pregna-4,15-dien-20-yn-3-one|-范德生物科技公司

Tosagestin

NMR下载 COA and HPLC MSDS下载
names：
17-Hydroxy-11-methylene-19-nor-17alpha-pregna-4,15-dien-20-yn-3-one
CAS号：
110072-15-6
MDL Number：
MF(分子式)： C21H24O2 MW(分子量)： 308.421
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	17-Hydroxy-11-methylene-19-nor-17alpha-pregna-4,15-dien-20-yn-3-one
英文别名	Tosagestin; Org-30659; Org 30659; Org30659.
CAS号	110072-15-6
SMILES	C#C[C@@]([C@]1(C2)C)(O)C=C[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])C2=C)=O
Inchi	InChI=1S/C21H24O2/c1-4-21(23)10-9-18-17-7-5-14-11-15(22)6-8-16(14)19(17)13(2)12-20(18,21)3/h1,9-11,16-19,23H,2,5-8,12H2,3H3/t16-,17-,18-,19+,20-,21+/m0/s1
InchiKey	YJSTYQGZKJHXLN-LEZSPFLNSA-N
分子式 Formula	C21H24O2
分子量 Molecular Weight	308.421
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tosagestin(CAS:110072-15-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tosagestin, also known as Org-30659, is a progesterone receptor agonist potentially use in contraception. Daily oral administration of 0.060-0.240 mg of Org 30659 suppresses ovarian function to a level sufficient to inhibit ovulation.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nieuwmeyer F, van der Voort Maarschalk K, Vromans H. Lactose contaminant as steroid degradation enhancer. Pharm Res. 2008 Nov;25(11):2666-73. doi: 10.1007/s11095-008-9687-z. Epub 2008 Aug [1]PubMed PMID: 18670867.

[2]de Visser SJ, Uchida N, van Vliet-Daskalopoulou E, Fukazawa I, van Doorn MB, van den Heuvel MW, Machielsen CS, Uchida E, Cohen AF. Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE). Contraception. 2003 Sep;68(3):195-202. PubMed PMID: 14561540.

[3] Verhoeven CH, van Munster TT, Groothuis GM, Vos RM, Rietjens IM. Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659. Xenobiotica. 2002 Feb;32(2):109-18. PubMed PMID: 11871398.

[4] Obruca A, Korver T, Huber J, Killick SR, Landgren B, Struijs MJ. Ovarian function during and after treatment with the new progestagen Org 30659. Fertil Steril. 2001 Jul;76(1):108-15. PubMed PMID: 11438328.

[5] Verhoeven CH, Gloudemans RH, Groothuis GM, Rietjens IM, Vos RM. Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48. PubMed PMID: 10822023.

6: Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM. In vitro and in vivo metabolism of the progestagen Org 30659 in several species. Drug Metab Dispos. 1998 Nov;26(11):1102-12. PubMed PMID: 9806953.7: Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):439-44. PubMed PMID: 8541241.8: Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines. J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):423-37. PubMed PMID: 8541240.9: van der Burg B, Kalkhoven E, Isbrücker L, de Laat SW. Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65. PubMed PMID: 1616875.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开