5786-82-3|Tetrahydrohomofolic acid|(4-((2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid|-范德生物科技公司

Tetrahydrohomofolic acid

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names：
(4-((2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
CAS号：
5786-82-3
MDL Number：
MF(分子式)： C20H25N7O6 MW(分子量)： 459.463
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(4-((2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
英文别名	Tetrahydrohomofolic acid; Homofolic acid, tetrahydro-; H4HF; THHF; Tetrahydrohomofolate;
CAS号	5786-82-3
Inchi	InChI=1S/C20H25N7O6/c21-20-26-16-15(18(31)27-20)24-12(9-23-16)7-8-22-11-3-1-10(2-4-11)17(30)25-13(19(32)33)5-6-14(28)29/h1-4,12-13,22,24H,5-9H2,(H,25,30)(H,28,29)(H,32,33)(H4,21,23,26,27,31)/t12?,13-/m0/s1
InchiKey	SVEJTXIHPDUQLZ-ABLWVSNPSA-N
分子式 Formula	C20H25N7O6
分子量 Molecular Weight	459.463
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tetrahydrohomofolic acid(CAS:5786-82-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tetrahydrohomofolic acid is an inhibitor of thymidylate synthetase; antibacterial & antimalarial.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Slieker LJ, Benkovic SJ. Inhibition of HKSV28 cell growth by 5,11-methenyl-tetrahydrohomofolate. Mol Pharmacol. 1984 Mar;25(2):294-302. PubMed PMID: 6700575.

[2]Wasserman GF, Benkovic PA, Young M, Benkovic SJ. Kinetic relationships between the various activities of the formyl-methenyl-methylenetetrahydrofolate synthetase. Biochemistry. 1983 Mar 1;22(5):1005-13. PubMed PMID: 6601493.

[3] Fong KL, Ho DH, Benjamin RS, Yang F, Sickler J, Brown NS, Bodey GP. A radioimmunoassay for 5-methyltetrahydrohomofolate. J Pharmacol Exp Ther. 1981 Aug;218(2):344-7. PubMed PMID: 6265623.

[4] Mishra LC, Mead JA. On the biochemical mechanism of action of tetrahydrohomofolic acid. Biochem Pharmacol. 1972 Feb 15;21(4):579-81. PubMed PMID: 5014514.

[5] Mishra LC, Parmar AS, Mead JA. Chemical transformations of tetrahydrohomofolic acid in vitro and in vivo. Chem Biol Interact. 1972 Jan;4(2):97-102. PubMed PMID: 5058329.

6: Mishra LC, Parmar AS, Mead JA. Distribution studies of tetrahydrohomofolic acid (NSC 89473) in mice. Cancer Res. 1970 Mar;30(3):642-9. PubMed PMID: 5425289.7: Kisliuk RL, Friedkin M, Reid V, Crawford EJ, Schmidt LH, Rossan R, Lewis D, Harrison J, Sullivan R. The toxicity of tetrahydrohomofolic acid in normal and malaria-infected monkeys. J Pharmacol Exp Ther. 1968 Feb;159(2):416-21. PubMed PMID: 4966294.8: Tong GL, Lee WW, Goodman L. Synthesis of a pyrimidine analog of tetrahydrohomofolic acid. J Med Chem. 1966 Jul;9(4):590-3. PubMed PMID: 5968029.

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