100440-25-3|Terpentecin|Oxiraneacetaldehyde, 2-(1-hydroxy-2-(1,2,3,4,4a,7,8,8a-octahydro-3-hydroxy-1,2,4a,5-tetramethyl-4-oxo-1-naphthalenyl)ethyl)-alpha-oxo-, (1-alpha(S*(R*)),2-alpha,3-beta,4a-beta,8a-alpha)-|-范德生物科技公司

Terpentecin

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names：
Oxiraneacetaldehyde, 2-(1-hydroxy-2-(1,2,3,4,4a,7,8,8a-octahydro-3-hydroxy-1,2,4a,5-tetramethyl-4-oxo-1-naphthalenyl)ethyl)-alpha-oxo-, (1-alpha(S*(R*)),2-alpha,3-beta,4a-beta,8a-alpha)-
CAS号：
100440-25-3
MDL Number：
MF(分子式)： C20H28O6 MW(分子量)： 364.438
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Oxiraneacetaldehyde, 2-(1-hydroxy-2-(1,2,3,4,4a,7,8,8a-octahydro-3-hydroxy-1,2,4a,5-tetramethyl-4-oxo-1-naphthalenyl)ethyl)-alpha-oxo-, (1-alpha(S(R)),2-alpha,3-beta,4a-beta,8a-alpha)-
英文别名	Terpentecin; Antibiotic MF 730N6; MF 730N6
CAS号	100440-25-3
Inchi	InChI=1S/C20H28O6/c1-11-6-5-7-13-18(3,12(2)16(24)17(25)19(11,13)4)8-14(22)20(10-26-20)15(23)9-21/h6,9,12-14,16,22,24H,5,7-8,10H2,1-4H3/t12?,13-,14+,16+,18?,19+,20-/m1/s1
InchiKey	ISTOHHFNKVUOKP-SHNWCLPJSA-N
分子式 Formula	C20H28O6
分子量 Molecular Weight	364.438
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Terpentecin(CAS:100440-25-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Terpentecin is isolated from strain MF730-N6 and is active against leukemia L-1210 and Ehrlich ascites carcinoma.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kawada S, Yamashita Y, Fujii N, Nakano H. Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin. Cancer Res. 1991 Jun 1;51(11):2922-5. PubMed PMID: 1851667.

[2]Tamamura T, Tsuchiya M, Isshiki K, Sawa T, Takeuchi T, Hori M, Sakata N. Terpentecin, an inhibitor of DNA synthesis. J Antibiot (Tokyo). 1988 May;41(5):648-54. PubMed PMID: 3290173.

[3] Isshiki K, Tamamura T, Sawa T, Naganawa H, Takeuchi T, Umezawa H. Biosynthetic studies of terpentecin. J Antibiot (Tokyo). 1986 Nov;39(11):1634-5. PubMed PMID: 3793635.

[4] Dairi T, Motohira Y, Kuzuyama T, Takahashi S, Itoh N, Seto H. Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotic-producing Streptomyces strains. Mol Gen Genet. 2000 Jan;262(6):957-64. PubMed PMID: 10660057.

[5] Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T. Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin. J Biol Chem. 2002 Oct 4;277(40):37098-104. Epub 2002 Jul 22. PubMed PMID: 12138123.

6: Arens JC, Haltli B, Kerr RG. Draft Genome Sequence of Kitasatospora griseola Strain MF730-N6, a Bafilomycin, Terpentecin, and Satosporin Producer. Genome Announc. 2015 Mar 26;3(2). pii: e00208-15. doi: 10.1128/genomeA.00208-15. PubMed PMID: 25814608; PubMed Central PMCID: PMC4384148.7: Kawada S, Yamashita Y, Ochiai K, Ando K, Iwasaki T, Takiguchi T, Nakano H. Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification. J Antibiot (Tokyo). 1995 Mar;48(3):211-6. PubMed PMID: 7730154.8: Isshiki K, Tamamura T, Takahashi Y, Sawa T, Naganawa H, Takeuchi T, Umezawa H. The structure of a new antibiotic, terpentecin. J Antibiot (Tokyo). 1985 Dec;38(12):1819-21. PubMed PMID: 3841540.9: Hamano Y, Dairi T, Yamamoto M, Kawasaki T, Kaneda K, Kuzuyama T, Itoh N, Seto H. Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. Biosci Biotechnol Biochem. 2001 Jul;65(7):1627-35. PubMed PMID: 11515548.10: Dairi T, Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H. Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. J Bacteriol. 2001 Oct;183(20):6085-94. PubMed PMID: 11567009; PubMed Central PMCID: PMC99688.1

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