53813-83-5|Suriclone|6-(7-chloro-1,8-naphthyridin-2-yl)-7-oxo-2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrol-5-yl 4-methylpiperazine-1-carboxylate|-范德生物科技公司

Suriclone

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names：
6-(7-chloro-1,8-naphthyridin-2-yl)-7-oxo-2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrol-5-yl 4-methylpiperazine-1-carboxylate
CAS号：
53813-83-5
MDL Number：
MF(分子式)： C20H20ClN5O3S2 MW(分子量)： 477.982
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	6-(7-chloro-1,8-naphthyridin-2-yl)-7-oxo-2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrol-5-yl 4-methylpiperazine-1-carboxylate
英文别名	Suriclone; RP 31264; RP-31264; RP31264
CAS号	53813-83-5
Inchi	InChI=1S/C20H20ClN5O3S2/c1-24-6-8-25(9-7-24)20(28)29-19-16-15(30-10-11-31-16)18(27)26(19)14-5-3-12-2-4-13(21)22-17(12)23-14/h2-5,19H,6-11H2,1H3
InchiKey	RMXOUBDDDQUBKD-UHFFFAOYSA-N
分子式 Formula	C20H20ClN5O3S2
分子量 Molecular Weight	477.982
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Suriclone(CAS:53813-83-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Suriclone, also known as RP-31264, is an anxiolytic drug belonging to the family of cyclopyrrolones. Suriclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties but with less amnestic effects. The mechanism of action by which suriclone produces its sedative and anxiolytic effects is by modulating GABA-A receptors, although suriclone is more subtype-selective than most benzodiazepines.
Application1
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危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Morishita H, Kushiku K, Matsuki J, Tokunaga T, Inoue T, Mori R, Kawamoto H, Furukawa T. Pharmacological effects of the antianxiety compound suriclone and its principal metabolites. Arzneimittelforschung. 1987 Dec;37(12):1332-40. PubMed PMID: 2896505.

[2]Ono H, Morishita S, Kasuya M, Kobayashi M, Miyamoto M, Oka J, Goto M, Fukuda H. Comparison of the effects of the new anxiolytic suriclone and benzodiazepines on motor function and electroencephalogram. Arzneimittelforschung. 1987 Apr;37(4):384-8. PubMed PMID: 2886128.

[3] Semlitsch HV, Anderer P, Saletu B. Acute effects of the anxiolytics suriclone and alprazolam on cognitive information processing utilizing topographic mapping of event-related brain potentials (P300) in healthy subjects. Eur J Clin Pharmacol. 1995;49(3):183-91. PubMed PMID: 8665994.

[4] Perault MC, Chapelle G, Bouquet S, Chevalier P, Montay G, Gaillot J, Chakroun H, Guillet P, Vandel B. Pharmacokinetic and pharmacodynamic study of suriclone imipramine interaction in man. Fundam Clin Pharmacol. 1994;8(3):251-5. PubMed PMID: 7927120.

[5] Brouillet E, Chavoix C, Hantraye P, Kunimoto M, Khalili-Varasteh M, Chevalier P, Frydman A, Gaillot J, Prenant C, Crouzel M, et al. Interaction of suriclone with central type benzodiazepine receptors in living baboons. Eur J Pharmacol. 1990 Jan 3;175(1):49-55. PubMed PMID: 1969798.

6: Shaw CA, Sellers EM, Sullivan JT, Kaplan HL. Comparative neurologic effects of diazepam and suriclone, a cyclopyrrolone anxiolytic. J Clin Psychopharmacol. 1988 Jun;8(3):189-92. PubMed PMID: 2897978.7: Saletu B, Grünberger J, Linzmayer L, Semlitsch HV, Anderer P, Chwatal K. Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry. Br J Clin Pharmacol. 1994 Feb;37(2):145-56. PubMed PMID: 7910470; PubMed Central PMCID: PMC1364591.8: Gilburt SJ, Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of suriclone on subjective sleep, psychomotor performance and cognitive function in young and elderly volunteers. Fundam Clin Pharmacol. 1992;6(6):251-8. PubMed PMID: 1362556.9: Allen D, Lader M. The interactions of ethanol with single and repeated doses of suriclone and diazepam on physiological and psychomotor functions in normal subjects. Eur J Clin Pharmacol. 1992;42(5):499-505. PubMed PMID: 1351467.10: Trifiletti RR, Snyder SH. Anxiolytic cyclopyrrolones zopiclone and suriclone bind to a novel site linked allosterically to benzodiazepine receptors. Mol Pharmacol. 1984 Nov;26(3):458-69. PubMed PMID: 6092896.

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