854402-59-8|SNJ-1945|((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester|-范德生物科技公司

SNJ-1945

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names：
((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
CAS号：
854402-59-8
MDL Number：
MF(分子式)： C25H37N3O7 MW(分子量)： 491.59
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
英文别名	SNJ1945; SNJ 1945; SNJ-1945
CAS号	854402-59-8
Inchi	InChI=1S/C25H37N3O7/c1-17(2)15-21(28-25(32)35-14-13-34-12-11-33-3)23(30)27-20(16-18-7-5-4-6-8-18)22(29)24(31)26-19-9-10-19/h4-8,17,19-21H,9-16H2,1-3H3,(H,26,31)(H,27,30)(H,28,32)/t20-,21-/m0/s1
InchiKey	PMEQLUMDXFJNRY-SFTDATJTSA-N
分子式 Formula	C25H37N3O7
分子量 Molecular Weight	491.59
溶解度Solubility
性状	White to off-white solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SNJ-1945(CAS:854402-59-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin as a cardioplegia.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Trager N, Smith A, Wallace Iv G, Azuma M, Inoue J, Beeson C, Haque A, Banik NL. Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis. J Neurochem. 2014 Jul;130(2):268-79. doi: 10.1111/jnc.12659. Epub 2014 Feb 12. PubMed PMID: 24447070; PubMed Central PMCID: PMC4107076.

[2]Knaryan VH, Samantaray S, Park S, Azuma M, Inoue J, Banik NL. SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP(+) and rotenone. J Neurochem. 2014 Jul;130(2):280-90. doi: 10.1111/jnc.12629. Epub 2013 Dec 16. PubMed PMID: 24341912; PubMed Central PMCID: PMC4038676.

[3] Bains M, Cebak JE, Gilmer LK, Barnes CC, Thompson SN, Geddes JW, Hall ED. Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model. J Neurochem. 2013 Apr;125(1):125-32. doi: 10.1111/jnc.12118. Epub 2013 Jan 28. PubMed PMID: 23216523.

[4] Yoshikawa Y, Zhang GX, Obata K, Matsuyoshi H, Asada K, Taniguchi S, Takaki M. A cardioprotective agent of a novel calpain inhibitor, SNJ-1945, exerts beta1 actions on left ventricular mechanical work and energetics. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H396-401. doi: 10.1152/ajpheart.00153.2010. Epub 2010 May 28. PubMed PMID: 20511411.

[5] Yoshikawa Y, Zhang GX, Obata K, Ohga Y, Matsuyoshi H, Taniguchi S, Takaki M. Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H643-51. doi: 10.1152/ajpheart.00849.2009. Epub 2009 Dec 4. PubMed PMID: 19966051.

6: Shimazawa M, Suemori S, Inokuchi Y, Matsunaga N, Nakajima Y, Oka T, Yamamoto T, Hara H. A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-me thylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo. J Pharmacol Exp Ther. 2010 Feb;332(2):380-7. doi: 10.1124/jpet.109.156612. Epub 2009 Nov 12. PubMed PMID: 19910537.7: Ma H, Tochigi A, Shearer TR, Azuma M. Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells. J Ocul Pharmacol Ther. 2009 Oct;25(5):409-14. doi: 10.1089/jop.2009.0030. PubMed PMID: 19857102; PubMed Central PMCID: PMC2958445.

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